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    TAS2R46 taste 2 receptor member 46 [ Homo sapiens (human) ]

    Gene ID: 259292, updated on 3-Apr-2024

    Summary

    Official Symbol
    TAS2R46provided by HGNC
    Official Full Name
    taste 2 receptor member 46provided by HGNC
    Primary source
    HGNC:HGNC:18877
    See related
    Ensembl:ENSG00000226761 MIM:612774; AllianceGenome:HGNC:18877
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    T2R46; T2R54
    Summary
    TAS2R46 belongs to the large TAS2R receptor family. TAS2Rs are expressed on the surface of taste receptor cells and mediate the perception of bitterness through a G protein-coupled second messenger pathway (Conte et al., 2002 [PubMed 12584440]). For further information on TAS2Rs, see MIM 604791.[supplied by OMIM, Sep 2009]
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    Genomic context

    See TAS2R46 in Genome Data Viewer
    Location:
    12p13.2
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (11061365..11062294, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (10936559..10937488, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (11213964..11214893, complement)

    Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene PRH1-PRR4 readthrough Neighboring gene proline rich protein HaeIII subfamily 1 Neighboring gene PRH1-TAS2R14 readthrough Neighboring gene taste 2 receptor member 31 Neighboring gene taste 2 receptor member 63 pseudogene Neighboring gene MPRA-validated peak1573 silencer Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr12:11223850-11224544 Neighboring gene taste 2 receptor member 64 pseudogene Neighboring gene taste 2 receptor member 43

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    GWAS of human bitter taste perception identifies new loci and reveals additional complexity of bitter taste genetics.
    EBI GWAS Catalog

    Pathways from PubChem

    General protein information

    Preferred Names
    taste receptor type 2 member 46
    Names
    taste receptor type 2 member 54
    taste receptor, type 2, member 46

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001426846.1NP_001413775.1  taste receptor type 2 member 46 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) represents an alternate 'A' allele of the SNP rs2708381, which results in a premature stop codon in T2T-CHM13 genome assembly. The resulting protein lacks one transmembrane domain, and is shorter than isoform 1.
      Source sequence(s)
      CP068266
      UniProtKB/TrEMBL
      A0A0J9YY42
    2. NM_176887.2NP_795368.2  taste receptor type 2 member 46 isoform 1

      See identical proteins and their annotated locations for NP_795368.2

      Status: VALIDATED

      Source sequence(s)
      AC018630
      Consensus CDS
      CCDS53748.1
      UniProtKB/Swiss-Prot
      P59540, P59548, Q645X6
      UniProtKB/TrEMBL
      Q50KH0
      Related
      ENSP00000436450.1, ENST00000533467.1
      Conserved Domains (1) summary
      pfam05296
      Location:1298
      TAS2R; Taste receptor protein (TAS2R)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

      Range
      11061365..11062294 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh38.p14 ALT_REF_LOCI_1

    Genomic

    1. NW_003571050.1 Reference GRCh38.p14 ALT_REF_LOCI_1

      Range
      260071..261000 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh38.p14 ALT_REF_LOCI_2

    Genomic

    1. NT_187658.1 Reference GRCh38.p14 ALT_REF_LOCI_2

      Range
      262229..263158 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060936.1 Alternate T2T-CHM13v2.0

      Range
      10936559..10937488 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)