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    Klk8 kallikrein related-peptidase 8 [ Mus musculus (house mouse) ]

    Gene ID: 259277, updated on 28-May-2024

    Summary

    Official Symbol
    Klk8provided by MGI
    Official Full Name
    kallikrein related-peptidase 8provided by MGI
    Primary source
    MGI:MGI:1343327
    See related
    Ensembl:ENSMUSG00000064023 AllianceGenome:MGI:1343327
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    NP; BSP1; Nrpn; Prss19
    Summary
    This gene encodes a member of the kallikrein subfamily of serine proteases that are involved in diverse physiological functions such as skin desquamation, tooth enamel formation, seminal liquefaction, synaptic neural plasticity and brain function. The encoded preproprotein undergoes proteolytic cleavage of the activation peptide to generate the functional enzyme. Mice lacking the encoded protein exhibit impaired long-term potentiation and increased anxiety, as well as a hyperkeratosis phenotype. This gene is located in a cluster of several related kallikrein genes on chromosome 7. [provided by RefSeq, May 2016]
    Expression
    Broad expression in stomach adult (RPKM 16.0), thymus adult (RPKM 5.0) and 17 other tissues See more
    Orthologs
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    Genomic context

    See Klk8 in Genome Data Viewer
    Location:
    7 B3; 7 28.26 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (43447001..43453250)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (43797532..43803826)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene kallikrein related-peptidase 10 Neighboring gene kallikrein related-peptidase 9 Neighboring gene kallikrein related-peptidase 7 (chymotryptic, stratum corneum) Neighboring gene kallikrein related-peptidase 6

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (2)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables peptidase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables peptidase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables serine-type endopeptidase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables serine-type endopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables serine-type peptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in keratinocyte proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in memory IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in memory IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in neuron projection morphogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in neuron projection morphogenesis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within proteolysis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of synapse organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in response to wounding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within synapse organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in secretory granule IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of serine protease inhibitor complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    kallikrein-8
    Names
    Brain Serine protease 1
    protease, serine, 19 (neuropsin)
    NP_001311327.1
    NP_032966.1
    XP_030098463.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001324398.1NP_001311327.1  kallikrein-8 preproprotein

      Status: REVIEWED

      Source sequence(s)
      AB074296, AC151989, EH106421
      Consensus CDS
      CCDS21182.1
      UniProtKB/Swiss-Prot
      Q61955, Q8K5D7
      UniProtKB/TrEMBL
      A0A0B6VRH9, A0A0U1RNI7
      Related
      ENSMUSP00000145580.2, ENSMUST00000205537.2
      Conserved Domains (1) summary
      smart00020
      Location:32252
      Tryp_SPc; Trypsin-like serine protease
    2. NM_008940.3NP_032966.1  kallikrein-8 preproprotein

      See identical proteins and their annotated locations for NP_032966.1

      Status: REVIEWED

      Source sequence(s)
      AB074296, AC151989, EH106421
      Consensus CDS
      CCDS21182.1
      UniProtKB/Swiss-Prot
      Q61955, Q8K5D7
      UniProtKB/TrEMBL
      A0A0B6VRH9, A0A0U1RNI7
      Related
      ENSMUSP00000082588.3, ENSMUST00000085461.4
      Conserved Domains (1) summary
      smart00020
      Location:32252
      Tryp_SPc; Trypsin-like serine protease

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      43447001..43453250
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030242603.2XP_030098463.1  kallikrein-8 isoform X1

      Conserved Domains (1) summary
      smart00020
      Location:1131
      Tryp_SPc; Trypsin-like serine protease