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    RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase [ Homo sapiens (human) ]

    Gene ID: 25897, updated on 5-Mar-2024

    Summary

    Official Symbol
    RNF19Aprovided by HGNC
    Official Full Name
    ring finger protein 19A, RBR E3 ubiquitin protein ligaseprovided by HGNC
    Primary source
    HGNC:HGNC:13432
    See related
    Ensembl:ENSG00000034677 MIM:607119; AllianceGenome:HGNC:13432
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    RNF19
    Summary
    This gene encodes a member of the ring between ring fingers (RBR) protein family, and the encoded protein contains two RING-finger motifs and an in between RING fingers motif. This protein is an E3 ubiquitin ligase that is localized to Lewy bodies, and ubiquitylates synphilin-1, which is an interacting protein of alpha synuclein in neurons. The encoded protein may be involved in amyotrophic lateral sclerosis and Parkinson's disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
    Expression
    Ubiquitous expression in testis (RPKM 28.2), gall bladder (RPKM 22.2) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See RNF19A in Genome Data Viewer
    Location:
    8q22.2
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (100257067..100336204, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (101381852..101460987, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (101269295..101348432, complement)

    Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene sperm associated antigen 1 Neighboring gene UFM1 pseudogene 3 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19411 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19412 Neighboring gene uncharacterized LOC105375669 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27686 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27687 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27688 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19413 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19414 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19415 Neighboring gene ReSE screen-validated silencer GRCh37_chr8:101322379-101322538 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27689 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27690 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27691 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:101347648-101348460 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:101348461-101349272 Neighboring gene uncharacterized LOC124901991 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27692 Neighboring gene microRNA 4471

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    Identification of genomic predictors of atrioventricular conduction: using electronic medical records as a tool for genome science.
    EBI GWAS Catalog

    HIV-1 interactions

    Replication interactions

    Interaction Pubs
    Knockdown of ring finger protein 19A, E3 ubiquitin protein ligase (RNF19A) by siRNA enhances the early stages of HIV-1 replication in HeLa-CD4 cells infected with viral pseudotypes HIV89.6R and HIV8.2N PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • DKFZp566B1346

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables ubiquitin conjugating enzyme binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in centrosome TAS
    Traceable Author Statement
    more info
    PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in glutamatergic synapse IEA
    Inferred from Electronic Annotation
    more info
     
    located_in hippocampal mossy fiber to CA3 synapse IEA
    Inferred from Electronic Annotation
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in postsynapse IEA
    Inferred from Electronic Annotation
    more info
     
    part_of ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    E3 ubiquitin-protein ligase RNF19A
    Names
    double ring-finger protein
    protein p38 interacting with transcription factor Sp1
    ring finger protein 19A, E3 ubiquitin protein ligase
    ring-IBR-ring domain containing protein Dorfin
    NP_001267468.1
    NP_001340766.1
    NP_001340767.1
    NP_056250.3
    NP_904355.1
    XP_047277620.1
    XP_047277621.1
    XP_047277622.1
    XP_047277623.1
    XP_047277624.1
    XP_047277625.1
    XP_047277626.1
    XP_047277627.1
    XP_047277628.1
    XP_047277629.1
    XP_047277631.1
    XP_047277632.1
    XP_054216220.1
    XP_054216221.1
    XP_054216222.1
    XP_054216223.1
    XP_054216224.1
    XP_054216225.1
    XP_054216226.1
    XP_054216227.1
    XP_054216228.1
    XP_054216229.1
    XP_054216230.1
    XP_054216231.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001280539.2NP_001267468.1  E3 ubiquitin-protein ligase RNF19A

      See identical proteins and their annotated locations for NP_001267468.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. Variants 1, 2, 3, 4, and 5 encode the same protein.
      Source sequence(s)
      AL122096, BC093938, BQ003778, DB061830
      Consensus CDS
      CCDS6286.1
      UniProtKB/Swiss-Prot
      A3KCU9, Q52LG1, Q9H5H9, Q9H8M8, Q9NV58, Q9UFG0, Q9UFX6, Q9Y4Y1
      Conserved Domains (4) summary
      smart00647
      Location:199264
      IBR; In Between Ring fingers
      pfam01485
      Location:297335
      IBR; IBR domain, a half RING-finger domain
      cd16775
      Location:131185
      RING-HC_RBR_RNF19A; RING finger, HC subclass, found in RING finger protein 19A (RNF19A) and similar proteins
      cl00570
      Location:361450
      AzlC; AzlC protein
    2. NM_001353837.2NP_001340766.1  E3 ubiquitin-protein ligase RNF19A

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR, compared to variant 1. Variants 1, 2, 3, 4, and 5 encode the same protein.
      Source sequence(s)
      AC025647, AP001574
      Consensus CDS
      CCDS6286.1
      UniProtKB/Swiss-Prot
      A3KCU9, Q52LG1, Q9H5H9, Q9H8M8, Q9NV58, Q9UFG0, Q9UFX6, Q9Y4Y1
      Conserved Domains (4) summary
      smart00647
      Location:199264
      IBR; In Between Ring fingers
      pfam01485
      Location:297335
      IBR; IBR domain, a half RING-finger domain
      cd16775
      Location:131185
      RING-HC_RBR_RNF19A; RING finger, HC subclass, found in RING finger protein 19A (RNF19A) and similar proteins
      cl00570
      Location:361450
      AzlC; AzlC protein
    3. NM_001353838.2NP_001340767.1  E3 ubiquitin-protein ligase RNF19A

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR, compared to variant 1. Variants 1, 2, 3, 4, and 5 encode the same protein.
      Source sequence(s)
      AC025647, AP001574
      Consensus CDS
      CCDS6286.1
      UniProtKB/Swiss-Prot
      A3KCU9, Q52LG1, Q9H5H9, Q9H8M8, Q9NV58, Q9UFG0, Q9UFX6, Q9Y4Y1
      Conserved Domains (4) summary
      smart00647
      Location:199264
      IBR; In Between Ring fingers
      pfam01485
      Location:297335
      IBR; IBR domain, a half RING-finger domain
      cd16775
      Location:131185
      RING-HC_RBR_RNF19A; RING finger, HC subclass, found in RING finger protein 19A (RNF19A) and similar proteins
      cl00570
      Location:361450
      AzlC; AzlC protein
    4. NM_015435.5NP_056250.3  E3 ubiquitin-protein ligase RNF19A

      See identical proteins and their annotated locations for NP_056250.3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1, 2, 3, 4, and 5 encode the same protein.
      Source sequence(s)
      AB029316, AL122096, AP001574, BC093938, BQ003778
      Consensus CDS
      CCDS6286.1
      UniProtKB/Swiss-Prot
      A3KCU9, Q52LG1, Q9H5H9, Q9H8M8, Q9NV58, Q9UFG0, Q9UFX6, Q9Y4Y1
      Related
      ENSP00000428968.1, ENST00000519449.5
      Conserved Domains (4) summary
      smart00647
      Location:199264
      IBR; In Between Ring fingers
      pfam01485
      Location:297335
      IBR; IBR domain, a half RING-finger domain
      cd16775
      Location:131185
      RING-HC_RBR_RNF19A; RING finger, HC subclass, found in RING finger protein 19A (RNF19A) and similar proteins
      cl00570
      Location:361450
      AzlC; AzlC protein
    5. NM_183419.4NP_904355.1  E3 ubiquitin-protein ligase RNF19A

      See identical proteins and their annotated locations for NP_904355.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2, 3, 4, and 5 encode the same protein.
      Source sequence(s)
      AL122096, BC093938, BQ003778, DB037264
      Consensus CDS
      CCDS6286.1
      UniProtKB/Swiss-Prot
      A3KCU9, Q52LG1, Q9H5H9, Q9H8M8, Q9NV58, Q9UFG0, Q9UFX6, Q9Y4Y1
      Related
      ENSP00000342667.2, ENST00000341084.7
      Conserved Domains (4) summary
      smart00647
      Location:199264
      IBR; In Between Ring fingers
      pfam01485
      Location:297335
      IBR; IBR domain, a half RING-finger domain
      cd16775
      Location:131185
      RING-HC_RBR_RNF19A; RING finger, HC subclass, found in RING finger protein 19A (RNF19A) and similar proteins
      cl00570
      Location:361450
      AzlC; AzlC protein

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

      Range
      100257067..100336204 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047421671.1XP_047277627.1  E3 ubiquitin-protein ligase RNF19A isoform X1

      UniProtKB/Swiss-Prot
      A3KCU9, Q52LG1, Q9H5H9, Q9H8M8, Q9NV58, Q9UFG0, Q9UFX6, Q9Y4Y1
    2. XM_047421673.1XP_047277629.1  E3 ubiquitin-protein ligase RNF19A isoform X1

      UniProtKB/Swiss-Prot
      A3KCU9, Q52LG1, Q9H5H9, Q9H8M8, Q9NV58, Q9UFG0, Q9UFX6, Q9Y4Y1
    3. XM_047421669.1XP_047277625.1  E3 ubiquitin-protein ligase RNF19A isoform X1

      UniProtKB/Swiss-Prot
      A3KCU9, Q52LG1, Q9H5H9, Q9H8M8, Q9NV58, Q9UFG0, Q9UFX6, Q9Y4Y1
    4. XM_047421664.1XP_047277620.1  E3 ubiquitin-protein ligase RNF19A isoform X1

      UniProtKB/Swiss-Prot
      A3KCU9, Q52LG1, Q9H5H9, Q9H8M8, Q9NV58, Q9UFG0, Q9UFX6, Q9Y4Y1
    5. XM_047421666.1XP_047277622.1  E3 ubiquitin-protein ligase RNF19A isoform X1

      UniProtKB/Swiss-Prot
      A3KCU9, Q52LG1, Q9H5H9, Q9H8M8, Q9NV58, Q9UFG0, Q9UFX6, Q9Y4Y1
    6. XM_047421668.1XP_047277624.1  E3 ubiquitin-protein ligase RNF19A isoform X1

      UniProtKB/Swiss-Prot
      A3KCU9, Q52LG1, Q9H5H9, Q9H8M8, Q9NV58, Q9UFG0, Q9UFX6, Q9Y4Y1
    7. XM_047421665.1XP_047277621.1  E3 ubiquitin-protein ligase RNF19A isoform X1

      UniProtKB/Swiss-Prot
      A3KCU9, Q52LG1, Q9H5H9, Q9H8M8, Q9NV58, Q9UFG0, Q9UFX6, Q9Y4Y1
    8. XM_047421667.1XP_047277623.1  E3 ubiquitin-protein ligase RNF19A isoform X1

      UniProtKB/Swiss-Prot
      A3KCU9, Q52LG1, Q9H5H9, Q9H8M8, Q9NV58, Q9UFG0, Q9UFX6, Q9Y4Y1
    9. XM_047421675.1XP_047277631.1  E3 ubiquitin-protein ligase RNF19A isoform X2

    10. XM_047421672.1XP_047277628.1  E3 ubiquitin-protein ligase RNF19A isoform X1

      UniProtKB/Swiss-Prot
      A3KCU9, Q52LG1, Q9H5H9, Q9H8M8, Q9NV58, Q9UFG0, Q9UFX6, Q9Y4Y1
    11. XM_047421670.1XP_047277626.1  E3 ubiquitin-protein ligase RNF19A isoform X1

      UniProtKB/Swiss-Prot
      A3KCU9, Q52LG1, Q9H5H9, Q9H8M8, Q9NV58, Q9UFG0, Q9UFX6, Q9Y4Y1
    12. XM_047421676.1XP_047277632.1  E3 ubiquitin-protein ligase RNF19A isoform X3

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060932.1 Alternate T2T-CHM13v2.0

      Range
      101381852..101460987 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054360252.1XP_054216227.1  E3 ubiquitin-protein ligase RNF19A isoform X1

      UniProtKB/Swiss-Prot
      A3KCU9, Q52LG1, Q9H5H9, Q9H8M8, Q9NV58, Q9UFG0, Q9UFX6, Q9Y4Y1
    2. XM_054360254.1XP_054216229.1  E3 ubiquitin-protein ligase RNF19A isoform X1

      UniProtKB/Swiss-Prot
      A3KCU9, Q52LG1, Q9H5H9, Q9H8M8, Q9NV58, Q9UFG0, Q9UFX6, Q9Y4Y1
    3. XM_054360250.1XP_054216225.1  E3 ubiquitin-protein ligase RNF19A isoform X1

      UniProtKB/Swiss-Prot
      A3KCU9, Q52LG1, Q9H5H9, Q9H8M8, Q9NV58, Q9UFG0, Q9UFX6, Q9Y4Y1
    4. XM_054360245.1XP_054216220.1  E3 ubiquitin-protein ligase RNF19A isoform X1

      UniProtKB/Swiss-Prot
      A3KCU9, Q52LG1, Q9H5H9, Q9H8M8, Q9NV58, Q9UFG0, Q9UFX6, Q9Y4Y1
    5. XM_054360247.1XP_054216222.1  E3 ubiquitin-protein ligase RNF19A isoform X1

      UniProtKB/Swiss-Prot
      A3KCU9, Q52LG1, Q9H5H9, Q9H8M8, Q9NV58, Q9UFG0, Q9UFX6, Q9Y4Y1
    6. XM_054360249.1XP_054216224.1  E3 ubiquitin-protein ligase RNF19A isoform X1

      UniProtKB/Swiss-Prot
      A3KCU9, Q52LG1, Q9H5H9, Q9H8M8, Q9NV58, Q9UFG0, Q9UFX6, Q9Y4Y1
    7. XM_054360246.1XP_054216221.1  E3 ubiquitin-protein ligase RNF19A isoform X1

      UniProtKB/Swiss-Prot
      A3KCU9, Q52LG1, Q9H5H9, Q9H8M8, Q9NV58, Q9UFG0, Q9UFX6, Q9Y4Y1
    8. XM_054360248.1XP_054216223.1  E3 ubiquitin-protein ligase RNF19A isoform X1

      UniProtKB/Swiss-Prot
      A3KCU9, Q52LG1, Q9H5H9, Q9H8M8, Q9NV58, Q9UFG0, Q9UFX6, Q9Y4Y1
    9. XM_054360255.1XP_054216230.1  E3 ubiquitin-protein ligase RNF19A isoform X2

    10. XM_054360253.1XP_054216228.1  E3 ubiquitin-protein ligase RNF19A isoform X1

      UniProtKB/Swiss-Prot
      A3KCU9, Q52LG1, Q9H5H9, Q9H8M8, Q9NV58, Q9UFG0, Q9UFX6, Q9Y4Y1
    11. XM_054360251.1XP_054216226.1  E3 ubiquitin-protein ligase RNF19A isoform X1

      UniProtKB/Swiss-Prot
      A3KCU9, Q52LG1, Q9H5H9, Q9H8M8, Q9NV58, Q9UFG0, Q9UFX6, Q9Y4Y1
    12. XM_054360256.1XP_054216231.1  E3 ubiquitin-protein ligase RNF19A isoform X3