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    DCAF13 DDB1 and CUL4 associated factor 13 [ Homo sapiens (human) ]

    Gene ID: 25879, updated on 5-May-2024

    Summary

    Official Symbol
    DCAF13provided by HGNC
    Official Full Name
    DDB1 and CUL4 associated factor 13provided by HGNC
    Primary source
    HGNC:HGNC:24535
    See related
    Ensembl:ENSG00000164934 MIM:616196; AllianceGenome:HGNC:24535
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    GM83; Sof1; WDSOF1; HSPC064
    Summary
    Enables estrogen receptor binding activity. Predicted to be involved in maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA). Located in several cellular components, including centrosome; cytosol; and nuclear lumen. Part of Cul4-RING E3 ubiquitin ligase complex. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in testis (RPKM 16.5), kidney (RPKM 11.1) and 25 other tissues See more
    Orthologs
    NEW
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    Genomic context

    Location:
    8q22.3
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (103415386..103443453)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (104543035..104571087)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (104427614..104455681)

    Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene RNA, U6 small nuclear 1011, pseudogene Neighboring gene H3K27ac hESC enhancer GRCh37_chr8:104427001-104427622 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:104430836-104431727 Neighboring gene solute carrier family 25 member 32 Neighboring gene uncharacterized LOC105375690 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19459 Neighboring gene Sharpr-MPRA regulatory region 6081 Neighboring gene regulating synaptic membrane exocytosis 2 Neighboring gene prothymosin alpha pseudogene 15

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC126859, MGC138247, DKFZp564O0463

    Gene Ontology Provided by GOA

    Component Evidence Code Pubs
    part_of Cul4-RING E3 ubiquitin ligase complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cell junction IDA
    Inferred from Direct Assay
    more info
     
    located_in centrosome IDA
    Inferred from Direct Assay
    more info
     
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
     
    is_active_in nucleolus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    part_of small-subunit processome IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    DDB1- and CUL4-associated factor 13
    Names
    WD repeat and SOF domain-containing protein 1
    WD repeats and SOF1 domain containing

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001416065.1NP_001402994.1  DDB1- and CUL4-associated factor 13 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC012213
    2. NM_015420.7NP_056235.5  DDB1- and CUL4-associated factor 13 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC012213, AK027799, CA429438
      Consensus CDS
      CCDS34934.2
      UniProtKB/Swiss-Prot
      Q3MII9, Q8NCH8, Q8TC51, Q96JY7, Q9NV06, Q9NZX3
      Related
      ENSP00000484962.1, ENST00000612750.5
      Conserved Domains (3) summary
      cd00200
      Location:59353
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:70107
      7WD40; WD40 repeat [structural motif]
      pfam04158
      Location:354435
      Sof1; Sof1-like domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

      Range
      103415386..103443453
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060932.1 Alternate T2T-CHM13v2.0

      Range
      104543035..104571087
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)