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    ABTB2 ankyrin repeat and BTB domain containing 2 [ Homo sapiens (human) ]

    Gene ID: 25841, updated on 5-Mar-2024

    Summary

    Official Symbol
    ABTB2provided by HGNC
    Official Full Name
    ankyrin repeat and BTB domain containing 2provided by HGNC
    Primary source
    HGNC:HGNC:23842
    See related
    Ensembl:ENSG00000166016 AllianceGenome:HGNC:23842
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ABTB2A; BTBD22
    Summary
    Predicted to enable protein heterodimerization activity. Predicted to act upstream of or within cellular response to toxic substance. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in kidney (RPKM 5.3), adrenal (RPKM 5.3) and 24 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See ABTB2 in Genome Data Viewer
    Location:
    11p13
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (34150987..34358010, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (34287990..34494746, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (34172534..34379557, complement)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124902660 Neighboring gene cell cycle associated protein 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4592 Neighboring gene N-acetyltransferase 10 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4593 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4594 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:34171467-34171996 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4595 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4596 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:34177103-34177604 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:34181811-34182311 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:34181310-34181810 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:34195130-34196052 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:34196053-34196973 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4597 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:34204513-34205014 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:34205015-34205514 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:34208067-34208830 Neighboring gene ReSE screen-validated silencer GRCh37_chr11:34213997-34214182 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:34214651-34215536 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:34215704-34216532 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4598 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:34226078-34226684 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr11:34255548-34256072 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:34260669-34261168 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:34261893-34262392 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr11:34263557-34264756 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:34264949-34265620 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4600 Neighboring gene Sharpr-MPRA regulatory region 14004 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:34306064-34306564 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:34306565-34307065 Neighboring gene MPRA-validated peak1251 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4601 Neighboring gene MMADHC pseudogene 2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4602 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3251 Neighboring gene CRISPRi-validated cis-regulatory element chr11.1764 Neighboring gene MPRA-validated peak1252 silencer Neighboring gene uncharacterized LOC105376622 Neighboring gene CIR1 pseudogene 3

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Vif vif HIV-1 Vif upregulates the expression of ankyrin repeat and BTB/POZ domain- containing protein 2 (ABTB2) in Vif-expression T cells PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • DKFZp586C1619

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein heterodimerization activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in cellular response to toxic substance IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    ankyrin repeat and BTB/POZ domain-containing protein 2
    Names
    ankyrin repeat and BTB (POZ) domain containing 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_145804.3NP_665803.2  ankyrin repeat and BTB/POZ domain-containing protein 2

      See identical proteins and their annotated locations for NP_665803.2

      Status: VALIDATED

      Source sequence(s)
      AC090469, AK291744, AL035079, AL050374
      Consensus CDS
      CCDS7890.2
      UniProtKB/Swiss-Prot
      A8K6S9, E9PRW7, Q52LD6, Q6MZW4, Q8N961, Q8NB44
      Related
      ENSP00000410157.2, ENST00000435224.3
      Conserved Domains (8) summary
      smart00225
      Location:846947
      BTB; Broad-Complex, Tramtrack and Bric a brac
      cd00204
      Location:516670
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd14821
      Location:947991
      SPOP_C_like; BACK-like Domain C-terminal to BTB in speckle-type POZ protein (SPOP) and similar proteins
      pfam00651
      Location:837940
      BTB; BTB/POZ domain
      pfam12796
      Location:526633
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:498542
      Ank_4; Ankyrin repeats (many copies)
      sd00045
      Location:524565
      ANK; ANK repeat [structural motif]
      cl23907
      Location:194242
      H2A; Histone 2A; H2A is a subunit of the nucleosome. The nucleosome is an octamer containing two H2A, H2B, H3, and H4 subunits. The H2A subunit performs essential roles in maintaining structural integrity of the nucleosome, chromatin condensation, and binding ...

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

      Range
      34150987..34358010 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060935.1 Alternate T2T-CHM13v2.0

      Range
      34287990..34494746 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)