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    COG4 component of oligomeric golgi complex 4 [ Homo sapiens (human) ]

    Gene ID: 25839, updated on 16-Jul-2021

    Summary

    Official Symbol
    COG4provided by HGNC
    Official Full Name
    component of oligomeric golgi complex 4provided by HGNC
    Primary source
    HGNC:HGNC:18620
    See related
    Ensembl:ENSG00000103051 MIM:606976
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    COD1; CDG2J; SWILS
    Summary
    The protein encoded by this gene is a component of an oligomeric protein complex involved in the structure and function of the Golgi apparatus. Defects in this gene may be a cause of congenital disorder of glycosylation type IIj. Two transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Aug 2010]
    Expression
    Ubiquitous expression in testis (RPKM 19.4), skin (RPKM 14.3) and 25 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See COG4 in Genome Data Viewer
    Location:
    16q22.1
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    109.20210514 current GRCh38.p13 (GCF_000001405.39) 16 NC_000016.10 (70480567..70523554, complement)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (70514470..70557457, complement)

    Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene RNA, U6 small nuclear 23, pseudogene Neighboring gene fucose kinase Neighboring gene small nucleolar RNA, C/D box 111B Neighboring gene splicing factor 3b subunit 3 Neighboring gene small nucleolar RNA, C/D box 111

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Replication interactions

    Interaction Pubs
    Knockdown of component of oligomeric golgi complex 4 (COG4) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • DKFZp586E1519

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in Golgi membrane TAS
    Traceable Author Statement
    more info
     
    part_of Golgi transport complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of Golgi transport complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    located_in trans-Golgi network membrane TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    conserved oligomeric Golgi complex subunit 4
    Names
    COG complex subunit 4
    complexed with Dor1p
    conserved oligomeric Golgi complex protein 4

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_027529.1 RefSeqGene

      Range
      5001..47984
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001195139.2NP_001182068.2  conserved oligomeric Golgi complex subunit 4 isoform 2

      Status: REVIEWED

      Source sequence(s)
      AC106804, AK096557, AL050101, AU125729, BP282697
      Consensus CDS
      CCDS73909.1
      Related
      ENSP00000501405.1, ENST00000674443.1
    2. NM_001365426.1NP_001352355.1  conserved oligomeric Golgi complex subunit 4 isoform 3

      Status: REVIEWED

      Source sequence(s)
      AC106804
    3. NM_015386.3NP_056201.2  conserved oligomeric Golgi complex subunit 4 isoform 1

      Status: REVIEWED

      Source sequence(s)
      AK096557, AL050101, AU125729, BP282697
      Consensus CDS
      CCDS10892.2
      UniProtKB/Swiss-Prot
      Q9H9E3
      UniProtKB/TrEMBL
      J3KNI1, Q8N8L9
      Related
      ENSP00000315775.5, ENST00000323786.10
      Conserved Domains (2) summary
      pfam08318
      Location:192501
      COG4; COG4 transport protein
      cl19885
      Location:551788
      Sec6; Exocyst complex component Sec6

    RNA

    1. NR_158212.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC106804
      Related
      ENST00000564415.6

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000016.10 Reference GRCh38.p13 Primary Assembly

      Range
      70480567..70523554 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024450224.1XP_024305992.1  conserved oligomeric Golgi complex subunit 4 isoform X2

      Related
      ENST00000530314.5
      Conserved Domains (3) summary
      pfam04437
      Location:263449
      RINT1_TIP1; RINT-1 / TIP-1 family
      pfam07393
      Location:358458
      Sec10; Exocyst complex component Sec10
      pfam08318
      Location:20195
      COG4; COG4 transport protein

    RNA

    1. XR_001751889.1 RNA Sequence

    2. XR_933267.1 RNA Sequence

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_145818.1: Suppressed sequence

      Description
      NM_145818.1: This RefSeq record was removed by NCBI staff. Contact info@ncbi.nlm.nih.gov for further information.
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