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    HECTD1 HECT domain E3 ubiquitin protein ligase 1 [ Homo sapiens (human) ]

    Gene ID: 25831, updated on 17-Jun-2024

    Summary

    Official Symbol
    HECTD1provided by HGNC
    Official Full Name
    HECT domain E3 ubiquitin protein ligase 1provided by HGNC
    Primary source
    HGNC:HGNC:20157
    See related
    Ensembl:ENSG00000092148 MIM:618649; AllianceGenome:HGNC:20157
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    EULIR
    Summary
    Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in anatomical structure development; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; and protein K63-linked ubiquitination. Predicted to act upstream of or within several processes, including animal organ development; negative regulation of protein localization to plasma membrane; and protein autoubiquitination. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in thyroid (RPKM 22.9), testis (RPKM 20.1) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See HECTD1 in Genome Data Viewer
    Location:
    14q12
    Exon count:
    45
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (31100117..31207793, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (25297934..25405840, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (31569323..31676999, complement)

    Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene striatin 3 Neighboring gene intraflagellar transport 20 homolog (Chlamydomonas) pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8227 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8228 Neighboring gene ReSE screen-validated silencer GRCh37_chr14:31494803-31494984 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5650 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5651 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8229 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:31516497-31517022 Neighboring gene adaptor related protein complex 4 subunit sigma 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5652 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:31591905-31592742 Neighboring gene ribosomal protein L21 pseudogene 5 Neighboring gene RNA, U6 small nuclear 541, pseudogene Neighboring gene Sharpr-MPRA regulatory region 7641 Neighboring gene H3K27ac hESC enhancer GRCh37_chr14:31675891-31676404 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5654 Neighboring gene H3K27ac hESC enhancer GRCh37_chr14:31676917-31677428 Neighboring gene H3K27ac hESC enhancer GRCh37_chr14:31677429-31677940 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:31721909-31722408 Neighboring gene Sharpr-MPRA regulatory region 13013 Neighboring gene Sharpr-MPRA regulatory region 11779 Neighboring gene uncharacterized LOC124903438 Neighboring gene asparaginyl-tRNA synthetase 1 pseudogene 1 Neighboring gene HEAT repeat containing 5A

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ38315, KIAA1131

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables ubiquitin protein ligase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables ubiquitin protein ligase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    involved_in anatomical structure development IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within aorta development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within heart valve development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in protein K63-linked ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within ventricular septum development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    is_active_in nuclear speck IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    E3 ubiquitin-protein ligase HECTD1
    Names
    E3 ligase for inhibin receptor
    HECT domain containing E3 ubiquitin protein ligase 1
    HECT domain-containing protein 1
    HECT-type E3 ubiquitin transferase HECTD1
    NP_001397939.1
    NP_056197.3
    XP_005267559.2
    XP_011534921.1
    XP_011534923.1
    XP_011534924.1
    XP_016876637.1
    XP_016876638.1
    XP_016876640.1
    XP_016876641.1
    XP_016876642.1
    XP_024305294.1
    XP_024305295.1
    XP_047287157.1
    XP_047287158.1
    XP_047287159.1
    XP_047287160.1
    XP_047287161.1
    XP_047287162.1
    XP_047287163.1
    XP_047287164.1
    XP_054231745.1
    XP_054231746.1
    XP_054231747.1
    XP_054231748.1
    XP_054231749.1
    XP_054231750.1
    XP_054231751.1
    XP_054231752.1
    XP_054231753.1
    XP_054231754.1
    XP_054231755.1
    XP_054231756.1
    XP_054231757.1
    XP_054231758.1
    XP_054231759.1
    XP_054231760.1
    XP_054231761.1
    XP_054231762.1
    XP_054231763.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001411010.1NP_001397939.1  E3 ubiquitin-protein ligase HECTD1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL121808, AL136418, KC877516
      Consensus CDS
      CCDS91860.1
      UniProtKB/TrEMBL
      A0A8I5QJU2, H0YJP0
      Related
      ENSP00000510470.1, ENST00000692835.1
    2. NM_015382.4NP_056197.3  E3 ubiquitin-protein ligase HECTD1 isoform 1

      See identical proteins and their annotated locations for NP_056197.3

      Status: VALIDATED

      Source sequence(s)
      AB032957, AL136418, AY254380, BM977042, DA440215, DA509926, DA818448
      Consensus CDS
      CCDS41939.1
      UniProtKB/Swiss-Prot
      D3DS86, Q6P445, Q86VJ1, Q96F34, Q9UFZ7, Q9ULT8
      UniProtKB/TrEMBL
      H0YJP0
      Related
      ENSP00000382269.1, ENST00000399332.6
      Conserved Domains (6) summary
      cd00078
      Location:21312608
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      sd00045
      Location:396426
      ANK; ANK repeat [structural motif]
      pfam06701
      Location:12771335
      MIB_HERC2; Mib_herc2
      pfam07738
      Location:11071240
      Sad1_UNC; Sad1 / UNC-like C-terminal
      pfam12796
      Location:366457
      Ank_2; Ankyrin repeats (3 copies)
      pfam18410
      Location:18921965
      BTHB; Basic tilted helix bundle domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

      Range
      31100117..31207793 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017021153.2XP_016876642.1  E3 ubiquitin-protein ligase HECTD1 isoform X10

      UniProtKB/TrEMBL
      A0A8I5KU01, H0YJD4
      Related
      ENSP00000451260.2, ENST00000554882.6
    2. XM_047431208.1XP_047287164.1  E3 ubiquitin-protein ligase HECTD1 isoform X11

      UniProtKB/TrEMBL
      A0A8I5KU01
    3. XM_011536621.3XP_011534923.1  E3 ubiquitin-protein ligase HECTD1 isoform X9

      See identical proteins and their annotated locations for XP_011534923.1

      UniProtKB/TrEMBL
      A0A8I5KU01
      Conserved Domains (6) summary
      cd00078
      Location:18522329
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      sd00045
      Location:396426
      ANK; ANK repeat [structural motif]
      pfam06701
      Location:12771302
      MIB_HERC2; Mib_herc2
      pfam07738
      Location:11071240
      Sad1_UNC; Sad1 / UNC-like C-terminal
      pfam12796
      Location:366457
      Ank_2; Ankyrin repeats (3 copies)
      pfam18410
      Location:16131686
      BTHB; Basic tilted helix bundle domain
    4. XM_047431201.1XP_047287157.1  E3 ubiquitin-protein ligase HECTD1 isoform X4

      UniProtKB/TrEMBL
      H0YJP0
    5. XM_047431206.1XP_047287162.1  E3 ubiquitin-protein ligase HECTD1 isoform X7

      UniProtKB/TrEMBL
      H0YJP0
    6. XM_047431204.1XP_047287160.1  E3 ubiquitin-protein ligase HECTD1 isoform X6

      UniProtKB/TrEMBL
      H0YJP0
    7. XM_011536619.3XP_011534921.1  E3 ubiquitin-protein ligase HECTD1 isoform X2

      See identical proteins and their annotated locations for XP_011534921.1

      UniProtKB/TrEMBL
      A0A087X2H1, H0YJP0
      Conserved Domains (6) summary
      cd00078
      Location:21292606
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      sd00045
      Location:396426
      ANK; ANK repeat [structural motif]
      pfam06701
      Location:12771335
      MIB_HERC2; Mib_herc2
      pfam07738
      Location:11071240
      Sad1_UNC; Sad1 / UNC-like C-terminal
      pfam12796
      Location:366457
      Ank_2; Ankyrin repeats (3 copies)
      pfam18410
      Location:18901963
      BTHB; Basic tilted helix bundle domain
    8. XM_047431202.1XP_047287158.1  E3 ubiquitin-protein ligase HECTD1 isoform X5

      UniProtKB/TrEMBL
      H0YJP0
    9. XM_005267502.4XP_005267559.2  E3 ubiquitin-protein ligase HECTD1 isoform X1

      See identical proteins and their annotated locations for XP_005267559.2

      UniProtKB/Swiss-Prot
      D3DS86, Q6P445, Q86VJ1, Q96F34, Q9UFZ7, Q9ULT8
      UniProtKB/TrEMBL
      H0YJP0
      Related
      ENSP00000450697.1, ENST00000553700.5
      Conserved Domains (6) summary
      cd00078
      Location:21312608
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      sd00045
      Location:396426
      ANK; ANK repeat [structural motif]
      pfam06701
      Location:12771335
      MIB_HERC2; Mib_herc2
      pfam07738
      Location:11071240
      Sad1_UNC; Sad1 / UNC-like C-terminal
      pfam12796
      Location:366457
      Ank_2; Ankyrin repeats (3 copies)
      pfam18410
      Location:18921965
      BTHB; Basic tilted helix bundle domain
    10. XM_017021152.3XP_016876641.1  E3 ubiquitin-protein ligase HECTD1 isoform X10

      UniProtKB/TrEMBL
      A0A8I5KU01, H0YJD4
    11. XM_017021151.3XP_016876640.1  E3 ubiquitin-protein ligase HECTD1 isoform X9

      UniProtKB/TrEMBL
      A0A8I5KU01
      Related
      ENSP00000508604.1, ENST00000691390.1
      Conserved Domains (6) summary
      cd00078
      Location:18522329
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      sd00045
      Location:396426
      ANK; ANK repeat [structural motif]
      pfam06701
      Location:12771302
      MIB_HERC2; Mib_herc2
      pfam07738
      Location:11071240
      Sad1_UNC; Sad1 / UNC-like C-terminal
      pfam12796
      Location:366457
      Ank_2; Ankyrin repeats (3 copies)
      pfam18410
      Location:16131686
      BTHB; Basic tilted helix bundle domain
    12. XM_047431207.1XP_047287163.1  E3 ubiquitin-protein ligase HECTD1 isoform X8

      UniProtKB/TrEMBL
      H0YJP0
    13. XM_017021149.3XP_016876638.1  E3 ubiquitin-protein ligase HECTD1 isoform X4

      UniProtKB/TrEMBL
      H0YJP0
      Conserved Domains (6) summary
      cd00078
      Location:20822559
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      sd00045
      Location:396426
      ANK; ANK repeat [structural motif]
      pfam06701
      Location:12771321
      MIB_HERC2; Mib_herc2
      pfam07738
      Location:11071240
      Sad1_UNC; Sad1 / UNC-like C-terminal
      pfam12796
      Location:366457
      Ank_2; Ankyrin repeats (3 copies)
      pfam18410
      Location:18431916
      BTHB; Basic tilted helix bundle domain
    14. XM_047431205.1XP_047287161.1  E3 ubiquitin-protein ligase HECTD1 isoform X7

      UniProtKB/TrEMBL
      H0YJP0
    15. XM_017021148.3XP_016876637.1  E3 ubiquitin-protein ligase HECTD1 isoform X3

      UniProtKB/TrEMBL
      A0A8I5QJU2, H0YJP0
      Conserved Domains (6) summary
      cd00078
      Location:20842561
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      sd00045
      Location:396426
      ANK; ANK repeat [structural motif]
      pfam06701
      Location:12771321
      MIB_HERC2; Mib_herc2
      pfam07738
      Location:11071240
      Sad1_UNC; Sad1 / UNC-like C-terminal
      pfam12796
      Location:366457
      Ank_2; Ankyrin repeats (3 copies)
      pfam18410
      Location:18451918
      BTHB; Basic tilted helix bundle domain
    16. XM_047431203.1XP_047287159.1  E3 ubiquitin-protein ligase HECTD1 isoform X6

      UniProtKB/TrEMBL
      H0YJP0
    17. XM_024449526.2XP_024305294.1  E3 ubiquitin-protein ligase HECTD1 isoform X2

      UniProtKB/TrEMBL
      A0A087X2H1, H0YJP0
      Related
      ENSP00000484981.2, ENST00000611816.5
      Conserved Domains (6) summary
      cd00078
      Location:21292606
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      sd00045
      Location:396426
      ANK; ANK repeat [structural motif]
      pfam06701
      Location:12771335
      MIB_HERC2; Mib_herc2
      pfam07738
      Location:11071240
      Sad1_UNC; Sad1 / UNC-like C-terminal
      pfam12796
      Location:366457
      Ank_2; Ankyrin repeats (3 copies)
      pfam18410
      Location:18901963
      BTHB; Basic tilted helix bundle domain
    18. XM_024449527.2XP_024305295.1  E3 ubiquitin-protein ligase HECTD1 isoform X5

      UniProtKB/TrEMBL
      H0YJP0
      Conserved Domains (5) summary
      cd00078
      Location:20702547
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      sd00045
      Location:396426
      ANK; ANK repeat [structural motif]
      pfam06701
      Location:12771335
      MIB_HERC2; Mib_herc2
      pfam07738
      Location:11071240
      Sad1_UNC; Sad1 / UNC-like C-terminal
      pfam12796
      Location:366457
      Ank_2; Ankyrin repeats (3 copies)
    19. XM_011536622.2XP_011534924.1  E3 ubiquitin-protein ligase HECTD1 isoform X12

      Conserved Domains (4) summary
      smart00119
      Location:16052057
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      cd00078
      Location:15812058
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      pfam06701
      Location:727785
      MIB_HERC2; Mib_herc2
      cl23730
      Location:557690
      F5_F8_type_C; F5/8 type C domain

    RNA

    1. XR_001750215.3 RNA Sequence

      Related
      ENST00000687002.1

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060938.1 Alternate T2T-CHM13v2.0

      Range
      25297934..25405840 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054375770.1XP_054231745.1  E3 ubiquitin-protein ligase HECTD1 isoform X1

      UniProtKB/Swiss-Prot
      D3DS86, Q6P445, Q86VJ1, Q96F34, Q9UFZ7, Q9ULT8
      UniProtKB/TrEMBL
      H0YJP0
    2. XM_054375776.1XP_054231751.1  E3 ubiquitin-protein ligase HECTD1 isoform X5

      UniProtKB/TrEMBL
      H0YJP0
    3. XM_054375772.1XP_054231747.1  E3 ubiquitin-protein ligase HECTD1 isoform X2

      UniProtKB/TrEMBL
      A0A087X2H1, H0YJP0
    4. XM_054375786.1XP_054231761.1  E3 ubiquitin-protein ligase HECTD1 isoform X10

      UniProtKB/TrEMBL
      A0A8I5KU01, H0YJD4
    5. XM_054375787.1XP_054231762.1  E3 ubiquitin-protein ligase HECTD1 isoform X11

      UniProtKB/TrEMBL
      A0A8I5KU01
    6. XM_054375783.1XP_054231758.1  E3 ubiquitin-protein ligase HECTD1 isoform X9

      UniProtKB/TrEMBL
      A0A8I5KU01
    7. XM_054375775.1XP_054231750.1  E3 ubiquitin-protein ligase HECTD1 isoform X4

      UniProtKB/TrEMBL
      H0YJP0
    8. XM_054375781.1XP_054231756.1  E3 ubiquitin-protein ligase HECTD1 isoform X7

      UniProtKB/TrEMBL
      H0YJP0
    9. XM_054375779.1XP_054231754.1  E3 ubiquitin-protein ligase HECTD1 isoform X6

      UniProtKB/TrEMBL
      H0YJP0
    10. XM_054375785.1XP_054231760.1  E3 ubiquitin-protein ligase HECTD1 isoform X10

      UniProtKB/TrEMBL
      A0A8I5KU01, H0YJD4
    11. XM_054375784.1XP_054231759.1  E3 ubiquitin-protein ligase HECTD1 isoform X9

      UniProtKB/TrEMBL
      A0A8I5KU01
    12. XM_054375782.1XP_054231757.1  E3 ubiquitin-protein ligase HECTD1 isoform X8

      UniProtKB/TrEMBL
      H0YJP0
    13. XM_054375774.1XP_054231749.1  E3 ubiquitin-protein ligase HECTD1 isoform X4

      UniProtKB/TrEMBL
      H0YJP0
    14. XM_054375780.1XP_054231755.1  E3 ubiquitin-protein ligase HECTD1 isoform X7

      UniProtKB/TrEMBL
      H0YJP0
    15. XM_054375773.1XP_054231748.1  E3 ubiquitin-protein ligase HECTD1 isoform X3

      UniProtKB/TrEMBL
      A0A8I5QJU2, H0YJP0
    16. XM_054375778.1XP_054231753.1  E3 ubiquitin-protein ligase HECTD1 isoform X6

      UniProtKB/TrEMBL
      H0YJP0
    17. XM_054375771.1XP_054231746.1  E3 ubiquitin-protein ligase HECTD1 isoform X2

      UniProtKB/TrEMBL
      A0A087X2H1, H0YJP0
    18. XM_054375777.1XP_054231752.1  E3 ubiquitin-protein ligase HECTD1 isoform X5

      UniProtKB/TrEMBL
      H0YJP0
    19. XM_054375788.1XP_054231763.1  E3 ubiquitin-protein ligase HECTD1 isoform X12

    RNA

    1. XR_008488851.1 RNA Sequence