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    CIZ1 CDKN1A interacting zinc finger protein 1 [ Homo sapiens (human) ]

    Gene ID: 25792, updated on 17-Jun-2024

    Summary

    Official Symbol
    CIZ1provided by HGNC
    Official Full Name
    CDKN1A interacting zinc finger protein 1provided by HGNC
    Primary source
    HGNC:HGNC:16744
    See related
    Ensembl:ENSG00000148337 MIM:611420; AllianceGenome:HGNC:16744
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    NP94; LSFR1; ZNF356
    Summary
    The protein encoded by this gene is a zinc finger DNA binding protein that interacts with CIP1, part of a complex with cyclin E. The encoded protein may regulate the cellular localization of CIP1. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012]
    Expression
    Ubiquitous expression in ovary (RPKM 30.0), testis (RPKM 29.2) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See CIZ1 in Genome Data Viewer
    Location:
    9q34.11
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (128166065..128204222, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (140373145..140411302, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (130928344..130966501, complement)

    Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20327 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:130916023-130916694 Neighboring gene MPRA-validated peak7335 silencer Neighboring gene ReSE screen-validated silencer GRCh37_chr9:130920069-130920264 Neighboring gene H3K27ac-H3K4me1 hESC enhancers GRCh37_chr9:130921445-130922398 and GRCh37_chr9:130922399-130923352 Neighboring gene lipocalin 2 Neighboring gene bublin coiled coil protein Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:130940513-130941204 Neighboring gene ReSE screen-validated silencer GRCh37_chr9:130953834-130954001 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:130954889-130955404 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:130955405-130955919 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29074 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20331 Neighboring gene Sharpr-MPRA regulatory region 9989 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:130966872-130967444 Neighboring gene dynamin 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancers GRCh37_chr9:130980103-130981059 and GRCh37_chr9:130981060-130982015 Neighboring gene ReSE screen-validated silencer GRCh37_chr9:130992962-130993210 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:130995155-130995654 Neighboring gene microRNA 199b Neighboring gene microRNA 3154

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables cyclin binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in maintenance of protein location in nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of DNA-templated DNA replication initiation IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
     

    General protein information

    Preferred Names
    cip1-interacting zinc finger protein
    Names
    nuclear protein NP94
    zinc finger protein 356

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_032983.1 RefSeqGene

      Range
      17812..43319
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001131015.2NP_001124487.1  cip1-interacting zinc finger protein isoform 2

      See identical proteins and their annotated locations for NP_001124487.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) has an alternate exon in place of the first exon, lacks an alternate in-frame exon, and lacks an alternate in-frame segment compared to variant 6. The resulting isoform (2) is shorter at the N-terminus and lacks two alternate internal segments compared to isoform 5.
      Source sequence(s)
      AK023978, BC004119, BC021163
      Consensus CDS
      CCDS48034.1
      UniProtKB/TrEMBL
      B4E0A3
      Related
      ENSP00000362039.3, ENST00000372948.7
      Conserved Domains (4) summary
      smart00451
      Location:536565
      ZnF_U1; U1-like zinc finger
      sd00020
      Location:600620
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam12171
      Location:630654
      zf-C2H2_jaz; Zinc-finger double-stranded RNA-binding
      cl26464
      Location:117426
      Atrophin-1; Atrophin-1 family
    2. NM_001131016.2NP_001124488.1  cip1-interacting zinc finger protein isoform 1

      See identical proteins and their annotated locations for NP_001124488.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) has an alternate exon in place of the first exon and lacks an alternate in-frame exon compared to variant 6. The resulting isoform (1) is shorter at the N-terminus and lacks an alternate internal segment compared to isoform 5. Variants 1 and 5 encode the same isoform (1).
      Source sequence(s)
      AK292713, AK303636, BC021163
      Consensus CDS
      CCDS6894.1
      UniProtKB/Swiss-Prot
      A8K9J8, B4E131, B7ZAS8, Q5SYW3, Q5SYW5, Q8WU72, Q9H868, Q9NYM8, Q9UHK4, Q9ULV3, Q9Y3F9, Q9Y3G0
      UniProtKB/TrEMBL
      B7Z3U7
      Related
      ENSP00000362029.5, ENST00000372938.10
      Conserved Domains (4) summary
      smart00451
      Location:592621
      ZnF_U1; U1-like zinc finger
      sd00020
      Location:656676
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam12171
      Location:686710
      zf-C2H2_jaz; Zinc-finger double-stranded RNA-binding
      cl26464
      Location:129482
      Atrophin-1; Atrophin-1 family
    3. NM_001131017.2NP_001124489.1  cip1-interacting zinc finger protein isoform 3

      See identical proteins and their annotated locations for NP_001124489.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) has an alternate exon in place of the first exon, lacks an alternate in-frame exon, and lacks an alternate in-frame segment compared to variant 6. The resulting isoform (3) is shorter at the N-terminus and lacks two alternate internal segments compared to isoform 5.
      Source sequence(s)
      AK303288, BC021163
      UniProtKB/TrEMBL
      B4E0A3
      Related
      ENSP00000498625.1, ENST00000651955.1
      Conserved Domains (4) summary
      smart00451
      Location:531560
      ZnF_U1; U1-like zinc finger
      COG5112
      Location:605656
      UFD2; U1-like Zn-finger-containing protein [General function prediction only]
      sd00020
      Location:595615
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam12171
      Location:625649
      zf-C2H2_jaz; Zinc-finger double-stranded RNA-binding
    4. NM_001131018.2NP_001124490.1  cip1-interacting zinc finger protein isoform 4

      See identical proteins and their annotated locations for NP_001124490.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) has an alternate exon in place of the first exon, lacks two alternate in-frame exons, and lacks an alternate in-frame segment compared to variant 6. The resulting isoform (4) is shorter at the N-terminus and lacks three alternate internal segments compared to isoform 5.
      Source sequence(s)
      BC021163, BM757318
      Consensus CDS
      CCDS48033.1
      UniProtKB/TrEMBL
      B4E0A3
      Related
      ENSP00000362045.1, ENST00000372954.5
      Conserved Domains (4) summary
      smart00451
      Location:512541
      ZnF_U1; U1-like zinc finger
      COG5112
      Location:586637
      UFD2; U1-like Zn-finger-containing protein [General function prediction only]
      sd00020
      Location:576596
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam12171
      Location:606630
      zf-C2H2_jaz; Zinc-finger double-stranded RNA-binding
    5. NM_001257975.2NP_001244904.1  cip1-interacting zinc finger protein isoform 5

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) represents the longest transcript. The resulting isoform (5) may be the longest isoform; however, the N-terminus of this isoform is only predicted and not supported by experimental data.
      Source sequence(s)
      AK296363, AL590708, BC021163
      Consensus CDS
      CCDS75910.1
      UniProtKB/TrEMBL
      B7Z3U7, F5H2X7
      Related
      ENSP00000439244.2, ENST00000538431.5
      Conserved Domains (2) summary
      smart00451
      Location:622651
      ZnF_U1; U1-like zinc finger
      pfam12171
      Location:742766
      zf-C2H2_jaz; Zinc-finger double-stranded RNA-binding
    6. NM_001257976.2NP_001244905.1  cip1-interacting zinc finger protein isoform 6

      See identical proteins and their annotated locations for NP_001244905.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7) has an alternate exon in place of the first exon, lacks an alternate in-frame exon, and lacks another alternate exon compared to variant 6, that causes a frameshift. The resulting isoform (6) is shorter at the N-terminus and lacks an alternate internal segment compared to isoform 5.
      Source sequence(s)
      AK303636, AL590708, BC021163
      Consensus CDS
      CCDS59147.1
      UniProtKB/TrEMBL
      H0Y5D5
      Related
      ENSP00000486816.1, ENST00000629610.2
      Conserved Domains (4) summary
      smart00451
      Location:491520
      ZnF_U1; U1-like zinc finger
      COG5112
      Location:565616
      UFD2; U1-like Zn-finger-containing protein [General function prediction only]
      sd00020
      Location:555575
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam12171
      Location:585609
      zf-C2H2_jaz; Zinc-finger double-stranded RNA-binding
    7. NM_012127.3NP_036259.2  cip1-interacting zinc finger protein isoform 1

      See identical proteins and their annotated locations for NP_036259.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) has an alternate exon in place of the first exon and lacks an alternate in-frame exon compared to variant 6. The resulting isoform (1) is shorter at the N-terminus and lacks an alternate internal segment compared to isoform 5. Variants 1 and 5 encode the same isoform (1).
      Source sequence(s)
      AF159025, AK023978, BC021163
      Consensus CDS
      CCDS6894.1
      UniProtKB/Swiss-Prot
      A8K9J8, B4E131, B7ZAS8, Q5SYW3, Q5SYW5, Q8WU72, Q9H868, Q9NYM8, Q9UHK4, Q9ULV3, Q9Y3F9, Q9Y3G0
      UniProtKB/TrEMBL
      B7Z3U7
      Related
      ENSP00000489425.1, ENST00000634901.1
      Conserved Domains (4) summary
      smart00451
      Location:592621
      ZnF_U1; U1-like zinc finger
      sd00020
      Location:656676
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam12171
      Location:686710
      zf-C2H2_jaz; Zinc-finger double-stranded RNA-binding
      cl26464
      Location:129482
      Atrophin-1; Atrophin-1 family

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

      Range
      128166065..128204222 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060933.1 Alternate T2T-CHM13v2.0

      Range
      140373145..140411302 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)