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    C10orf67 chromosome 10 open reading frame 67 [ Homo sapiens (human) ]

    Gene ID: 256815, updated on 3-Apr-2024

    Summary

    Official Symbol
    C10orf67provided by HGNC
    Official Full Name
    chromosome 10 open reading frame 67provided by HGNC
    Primary source
    HGNC:HGNC:28716
    See related
    Ensembl:ENSG00000179133 AllianceGenome:HGNC:28716
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    C10orf115; LINC01552
    Summary
    Predicted to be located in mitochondrion. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in testis (RPKM 1.5), lung (RPKM 0.5) and 2 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See C10orf67 in Genome Data Viewer
    Location:
    10p12.2
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (23201916..23344797, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (23220910..23364923, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (23490845..23633726, complement)

    Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124900299 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:23484130-23484885 Neighboring gene pancreas associated transcription factor 1a Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3151 Neighboring gene C10orf67 antisense RNA 1 Neighboring gene Sharpr-MPRA regulatory region 3018 Neighboring gene uncharacterized LOC124902591 Neighboring gene NANOG hESC enhancer GRCh37_chr10:23698923-23699424 Neighboring gene MPRA-validated peak907 silencer Neighboring gene MPRA-validated peak908 silencer Neighboring gene MIR1254-2-OTUD1 intergenic CAGE-defined monocyte enhancer Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2217 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2218 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2219 Neighboring gene OTU deubiquitinase 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Phenotypes

    EBI GWAS Catalog

    Description
    Genome-wide association analysis in sarcoidosis and Crohn's disease unravels a common susceptibility locus on 10p12.2.
    EBI GWAS Catalog

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General protein information

    Preferred Names
    uncharacterized protein C10orf67, mitochondrial
    Names
    long intergenic non-protein coding RNA 1552

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001351306.2NP_001338235.1  uncharacterized protein C10orf67, mitochondrial isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL592296, AL606469, BC035732
      UniProtKB/TrEMBL
      A0A3B3IRX4
      Related
      ENSP00000497121.1, ENST00000649478.1
      Conserved Domains (1) summary
      pfam15821
      Location:70179
      DUF4709; Domain of unknown function (DUF4709)
    2. NM_001365862.2NP_001352791.1  uncharacterized protein C10orf67, mitochondrial isoform 3 precursor

      Status: VALIDATED

      Source sequence(s)
      AL139281, AL592296, AL606469
      UniProtKB/Swiss-Prot
      A8MUP9, Q5QP74, Q5SWD4, Q8IYJ2
      Conserved Domains (3) summary
      pfam15821
      Location:70179
      DUF4709; Domain of unknown function (DUF4709)
      pfam15852
      Location:458544
      DUF4724; Domain of unknown function (DUF4724)
      cl25732
      Location:208439
      SMC_N; RecF/RecN/SMC N terminal domain
    3. NM_001371909.1NP_001358838.1  uncharacterized protein C10orf67, mitochondrial isoform 4

      Status: VALIDATED

      Source sequence(s)
      AL139281, AL592296, AL606469
      Consensus CDS
      CCDS91221.1
      UniProtKB/TrEMBL
      A0A6E2AE84
      Related
      ENSP00000490528.2, ENST00000636213.3
      Conserved Domains (3) summary
      COG1196
      Location:97441
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam15852
      Location:457545
      DUF4724; Domain of unknown function (DUF4724)
      pfam15821
      Location:69178
      DUF4709; Domain of unknown function (DUF4709)
    4. NM_153714.3NP_714925.2  uncharacterized protein C10orf67, mitochondrial isoform 1

      See identical proteins and their annotated locations for NP_714925.2

      Status: VALIDATED

      Source sequence(s)
      AL592296, AL606469
      Consensus CDS
      CCDS44365.1
      UniProtKB/TrEMBL
      A0A6E1W0W4
      Related
      ENSP00000501139.1, ENST00000673651.1
      Conserved Domains (1) summary
      pfam15821
      Location:70179
      DUF4709; Domain of unknown function (DUF4709)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

      Range
      23201916..23344797 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017016031.2XP_016871520.1  uncharacterized protein C10orf67, mitochondrial isoform X3

    2. XM_047424968.1XP_047280924.1  uncharacterized protein C10orf67, mitochondrial isoform X1

    3. XM_011519443.2XP_011517745.1  uncharacterized protein C10orf67, mitochondrial isoform X7

      Conserved Domains (1) summary
      pfam15852
      Location:184270
      DUF4724; Domain of unknown function (DUF4724)
    4. XM_047424970.1XP_047280926.1  uncharacterized protein C10orf67, mitochondrial isoform X2

      Related
      ENSP00000490237.1, ENST00000376501.7
    5. XM_011519440.2XP_011517742.1  uncharacterized protein C10orf67, mitochondrial isoform X4

      UniProtKB/TrEMBL
      A0A1B0GUT5
      Conserved Domains (2) summary
      pfam13118
      Location:266317
      DUF3972; Protein of unknown function (DUF3972)
      pfam15821
      Location:70179
      DUF4709; Domain of unknown function (DUF4709)
    6. XM_011519441.2XP_011517743.1  uncharacterized protein C10orf67, mitochondrial isoform X5

      UniProtKB/TrEMBL
      A0A1B0GUT5
      Conserved Domains (2) summary
      pfam15821
      Location:70179
      DUF4709; Domain of unknown function (DUF4709)
      cl19548
      Location:100405
      DUF515; Protein of unknown function (DUF515)
    7. XM_011519442.3XP_011517744.1  uncharacterized protein C10orf67, mitochondrial isoform X6

      UniProtKB/TrEMBL
      A0A1B0GUT5
      Conserved Domains (2) summary
      pfam13118
      Location:266317
      DUF3972; Protein of unknown function (DUF3972)
      pfam15821
      Location:70179
      DUF4709; Domain of unknown function (DUF4709)
    8. XM_011519445.3XP_011517747.1  uncharacterized protein C10orf67, mitochondrial isoform X8

      UniProtKB/TrEMBL
      A0A6E1W0W4
      Conserved Domains (1) summary
      pfam15821
      Location:70179
      DUF4709; Domain of unknown function (DUF4709)
    9. XM_011519446.2XP_011517748.1  uncharacterized protein C10orf67, mitochondrial isoform X9

      See identical proteins and their annotated locations for XP_011517748.1

      UniProtKB/TrEMBL
      A0A6E1W0W4
      Conserved Domains (1) summary
      pfam15821
      Location:70179
      DUF4709; Domain of unknown function (DUF4709)

    RNA

    1. XR_930487.2 RNA Sequence

    2. XR_930488.2 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060934.1 Alternate T2T-CHM13v2.0

      Range
      23220910..23364923 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054365424.1XP_054221399.1  uncharacterized protein C10orf67, mitochondrial isoform X3

    2. XM_054365422.1XP_054221397.1  uncharacterized protein C10orf67, mitochondrial isoform X1

    3. XM_054365428.1XP_054221403.1  uncharacterized protein C10orf67, mitochondrial isoform X7

    4. XM_054365423.1XP_054221398.1  uncharacterized protein C10orf67, mitochondrial isoform X2

    5. XM_054365425.1XP_054221400.1  uncharacterized protein C10orf67, mitochondrial isoform X4

    6. XM_054365426.1XP_054221401.1  uncharacterized protein C10orf67, mitochondrial isoform X5

    7. XM_054365427.1XP_054221402.1  uncharacterized protein C10orf67, mitochondrial isoform X6

    8. XM_054365429.1XP_054221404.1  uncharacterized protein C10orf67, mitochondrial isoform X8

    9. XM_054365430.1XP_054221405.1  uncharacterized protein C10orf67, mitochondrial isoform X9

    RNA

    1. XR_008488190.1 RNA Sequence

    2. XR_008488191.1 RNA Sequence