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    Fn1 fibronectin 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 25661, updated on 10-Jul-2024

    Summary

    Official Symbol
    Fn1provided by RGD
    Official Full Name
    fibronectin 1provided by RGD
    Primary source
    RGD:2624
    See related
    EnsemblRapid:ENSRNOG00000014288 AllianceGenome:RGD:2624
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    fn-1; FIBNEC
    Summary
    Enables mercury ion binding activity and protease binding activity. Involved in several processes, including cellular response to growth factor stimulus; cellular response to mercury ion; and cellular response to peptide. Located in basement membrane and extracellular space. Used to study diabetic angiopathy; hypertension; and renovascular hypertension. Biomarker of several diseases, including artery disease (multiple); calcium oxalate nephrolithiasis; iron deficiency anemia; membranoproliferative glomerulonephritis; and ureteral obstruction. Human ortholog(s) of this gene implicated in calcium oxalate nephrolithiasis; membranoproliferative glomerulonephritis; and spondylometaphyseal dysplasia corner fracture type. Orthologous to human FN1 (fibronectin 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Liver (RPKM 1817.5), Lung (RPKM 1002.6) and 6 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Fn1 in Genome Data Viewer
    Location:
    9q33
    Exon count:
    46
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (80645507..80714200, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (73196044..73264695, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (78900111..78969018, complement)

    Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134480587 Neighboring gene 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase Neighboring gene uncharacterized LOC120094699 Neighboring gene uncharacterized LOC102554186 Neighboring gene nucleolar protein 56-like

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables extracellular matrix structural constituent TAS
    Traceable Author Statement
    more info
    PubMed 
    enables heparin binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables identical protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables integrin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables integrin binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables integrin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables mercury ion binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables peptidase activator activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables peptidase activator activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protease binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protease binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protease binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables proteoglycan binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables proteoglycan binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables proteoglycan binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables receptor ligand activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables signaling receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in acute-phase response IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in angiogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in biological process involved in interaction with symbiont IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in calcium-independent cell-matrix adhesion IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within calcium-independent cell-matrix adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cell adhesion IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within cell adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cell-matrix adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cell-matrix adhesion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within cell-matrix adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cell-substrate junction assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cell-substrate junction assembly IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within cell-substrate junction assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to BMP stimulus IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in cellular response to amyloid-beta IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in cellular response to angiotensin IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in cellular response to glucose stimulus IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in cellular response to interleukin-1 IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cellular response to lipopolysaccharide IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in cellular response to mercury ion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cellular response to platelet-derived growth factor stimulus IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in cellular response to prostaglandin E stimulus IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in cellular response to transforming growth factor beta stimulus IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in cellular response to vascular endothelial growth factor stimulus IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in endodermal cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in endodermal cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in extracellular matrix organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in glial cell migration IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in heart development IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in integrin activation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in integrin activation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in integrin-mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in integrin-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of collagen biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of monocyte activation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of monocyte activation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of transforming growth factor beta production IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of transforming growth factor beta production ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in nervous system development IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in neural crest cell migration involved in autonomic nervous system development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in neural crest cell migration involved in autonomic nervous system development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in ossification TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in positive regulation of axon extension IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within positive regulation of axon extension ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cell migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of chemotaxis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of fibroblast proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of fibroblast proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of gene expression IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of substrate-dependent cell migration, cell attachment to substrate IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of substrate-dependent cell migration, cell attachment to substrate ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of ERK1 and ERK2 cascade IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of ERK1 and ERK2 cascade ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of cell shape IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to activity IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to glucocorticoid IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to iron ion IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to ischemia IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to muscle activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to ozone IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to xenobiotic stimulus IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in substrate adhesion-dependent cell spreading IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in substrate adhesion-dependent cell spreading ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in wound healing IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within wound healing ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in apical plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in apical plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in basement membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in basement membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in basement membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in collagen-containing extracellular matrix IEA
    Inferred from Electronic Annotation
    more info
     
    located_in collagen-containing extracellular matrix ISO
    Inferred from Sequence Orthology
    more info
     
    located_in endoplasmic reticulum-Golgi intermediate compartment IEA
    Inferred from Electronic Annotation
    more info
     
    located_in endoplasmic reticulum-Golgi intermediate compartment ISO
    Inferred from Sequence Orthology
    more info
     
    located_in extracellular exosome IEA
    Inferred from Electronic Annotation
    more info
     
    located_in extracellular exosome ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in extracellular matrix ISO
    Inferred from Sequence Orthology
    more info
     
    located_in extracellular matrix ISO
    Inferred from Sequence Orthology
    more info
     
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
     
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
     
    part_of fibrinogen complex IEA
    Inferred from Electronic Annotation
    more info
     
    part_of fibrinogen complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    fibronectin
    Names
    FN
    fibronectin 2
    fibronectin 3

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_019143.2NP_062016.2  fibronectin precursor

      See identical proteins and their annotated locations for NP_062016.2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000009
      UniProtKB/Swiss-Prot
      P04937, Q6LDX9
      UniProtKB/TrEMBL
      A0A096P6L8, A6KFG8
      Related
      ENSRNOP00000019772.4, ENSRNOT00000019772.8
      Conserved Domains (6) summary
      smart00059
      Location:353401
      FN2; Fibronectin type 2 domain
      smart00058
      Location:187231
      FN1; Fibronectin type 1 domain
      cd00061
      Location:23842423
      FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...
      cd00063
      Location:19942074
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00039
      Location:232271
      fn1; Fibronectin type I domain
      pfam00041
      Location:15391620
      fn3; Fibronectin type III domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086027.1 Reference GRCr8

      Range
      80645507..80714200 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006245156.5XP_006245218.1  fibronectin isoform X7

      See identical proteins and their annotated locations for XP_006245218.1

      UniProtKB/TrEMBL
      A0A8I5ZXR2, A6KFG4
      Conserved Domains (6) summary
      smart00059
      Location:353401
      FN2; Fibronectin type 2 domain
      smart00058
      Location:187231
      FN1; Fibronectin type 1 domain
      cd00061
      Location:22032242
      FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...
      cd00063
      Location:18131893
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00039
      Location:232271
      fn1; Fibronectin type I domain
      pfam00041
      Location:14481529
      fn3; Fibronectin type III domain
    2. XM_006245159.5XP_006245221.1  fibronectin isoform X11

      UniProtKB/TrEMBL
      A6KFG7
      Conserved Domains (6) summary
      smart00059
      Location:353401
      FN2; Fibronectin type 2 domain
      smart00058
      Location:187231
      FN1; Fibronectin type 1 domain
      cd00061
      Location:20832122
      FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...
      cd00063
      Location:18131893
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00039
      Location:232271
      fn1; Fibronectin type I domain
      pfam00041
      Location:14481529
      fn3; Fibronectin type III domain
    3. XM_006245157.5XP_006245219.1  fibronectin isoform X8

      UniProtKB/TrEMBL
      A0A8I5ZXR2
      Conserved Domains (6) summary
      smart00059
      Location:353401
      FN2; Fibronectin type 2 domain
      smart00058
      Location:187231
      FN1; Fibronectin type 1 domain
      cd00061
      Location:21782217
      FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...
      cd00063
      Location:18131893
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00039
      Location:232271
      fn1; Fibronectin type I domain
      pfam00041
      Location:14481529
      fn3; Fibronectin type III domain
    4. XM_006245158.5XP_006245220.1  fibronectin isoform X10

      UniProtKB/TrEMBL
      A6KFG7
      Conserved Domains (6) summary
      smart00059
      Location:353401
      FN2; Fibronectin type 2 domain
      smart00058
      Location:187231
      FN1; Fibronectin type 1 domain
      cd00061
      Location:21732212
      FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...
      cd00063
      Location:19031983
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00039
      Location:232271
      fn1; Fibronectin type I domain
      pfam00041
      Location:14481529
      fn3; Fibronectin type III domain
    5. XM_006245153.5XP_006245215.1  fibronectin isoform X5

      UniProtKB/Swiss-Prot
      P04937, Q6LDX9
      Conserved Domains (6) summary
      smart00059
      Location:353401
      FN2; Fibronectin type 2 domain
      smart00058
      Location:187231
      FN1; Fibronectin type 1 domain
      cd00061
      Location:22682307
      FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...
      cd00063
      Location:19031983
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00039
      Location:232271
      fn1; Fibronectin type I domain
      pfam00041
      Location:14481529
      fn3; Fibronectin type III domain
    6. XM_006245152.5XP_006245214.1  fibronectin isoform X3

      See identical proteins and their annotated locations for XP_006245214.1

      UniProtKB/Swiss-Prot
      P04937, Q6LDX9
      UniProtKB/TrEMBL
      A0A8I6A5M1, A6KFG5
      Related
      ENSRNOP00000087332.1, ENSRNOT00000110905.2
      Conserved Domains (6) summary
      smart00059
      Location:353401
      FN2; Fibronectin type 2 domain
      smart00058
      Location:187231
      FN1; Fibronectin type 1 domain
      cd00061
      Location:22932332
      FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...
      cd00063
      Location:19031983
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00039
      Location:232271
      fn1; Fibronectin type I domain
      pfam00041
      Location:14481529
      fn3; Fibronectin type III domain
    7. XM_017596301.3XP_017451790.1  fibronectin isoform X9

      UniProtKB/TrEMBL
      A6KFG7
    8. XM_039083090.2XP_038939018.1  fibronectin isoform X4

      UniProtKB/TrEMBL
      A0A8I5ZXR2
      Conserved Domains (6) summary
      smart00059
      Location:353401
      FN2; Fibronectin type 2 domain
      smart00058
      Location:187231
      FN1; Fibronectin type 1 domain
      cd00061
      Location:22692308
      FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...
      cd00063
      Location:19041984
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00039
      Location:232271
      fn1; Fibronectin type I domain
      pfam00041
      Location:15391620
      fn3; Fibronectin type III domain
    9. XM_006245151.5XP_006245213.1  fibronectin isoform X2

      See identical proteins and their annotated locations for XP_006245213.1

      UniProtKB/TrEMBL
      A0A8I5ZXR2, A6KFG6, F1LST1
      Related
      ENSRNOP00000054395.4, ENSRNOT00000057585.6
      Conserved Domains (6) summary
      smart00059
      Location:353401
      FN2; Fibronectin type 2 domain
      smart00058
      Location:187231
      FN1; Fibronectin type 1 domain
      cd00061
      Location:22942333
      FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...
      cd00063
      Location:19041984
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00039
      Location:232271
      fn1; Fibronectin type I domain
      pfam00041
      Location:15391620
      fn3; Fibronectin type III domain
    10. XM_006245154.5XP_006245216.1  fibronectin isoform X6

      UniProtKB/TrEMBL
      A6KFG7
      Conserved Domains (6) summary
      smart00059
      Location:353401
      FN2; Fibronectin type 2 domain
      smart00058
      Location:187231
      FN1; Fibronectin type 1 domain
      cd00061
      Location:22642303
      FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...
      cd00063
      Location:19942074
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00039
      Location:232271
      fn1; Fibronectin type I domain
      pfam00041
      Location:15391620
      fn3; Fibronectin type III domain
    11. XM_006245150.5XP_006245212.1  fibronectin isoform X1

      UniProtKB/Swiss-Prot
      P04937, Q6LDX9
      Conserved Domains (6) summary
      smart00059
      Location:353401
      FN2; Fibronectin type 2 domain
      smart00058
      Location:187231
      FN1; Fibronectin type 1 domain
      cd00061
      Location:23592398
      FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...
      cd00063
      Location:19942074
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00039
      Location:232271
      fn1; Fibronectin type I domain
      pfam00041
      Location:15391620
      fn3; Fibronectin type III domain