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    chp1 heterochromatin (HP1) family chromodomain protein Chp1 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2542239, updated on 18-Sep-2024

    Summary

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    Official Symbol
    chp1
    Official Full Name
    heterochromatin (HP1) family chromodomain protein Chp1
    Primary source
    PomBase:SPAC18G6.02c
    Locus tag
    SPOM_SPAC18G6.02C
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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    Genomic context

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    See chp1 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    1
    Sequence:
    Chromosome: I; NC_003424.3 (2210810..2214345, complement)

    Chromosome I - NC_003424.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene chalcone related protein Neighboring gene ncRNA Neighboring gene tRNA-Val Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003424.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Chp1-Tas3 core is a multifunctional platform critical for gene silencing by RITS. Schalch T, et al. Nat Struct Mol Biol, 2011 Nov 13. PMID 22081013, Free PMC Article
    2. Nuclear aconitase antagonizes heterochromatic silencing by interfering with Chp1 binding to DNA. Jung SJ, et al. Biochem Biophys Res Commun, 2019 Aug 27. PMID 31255284
    3. RNA interference (RNAi)-dependent and RNAi-independent association of the Chp1 chromodomain protein with distinct heterochromatic loci in fission yeast. Petrie VJ, et al. Mol Cell Biol, 2005 Mar. PMID 15743828, Free PMC Article
    4. Chp1-Tas3 interaction is required to recruit RITS to fission yeast centromeres and for maintenance of centromeric heterochromatin. Debeauchamp JL, et al. Mol Cell Biol, 2008 Apr. PMID 18212052, Free PMC Article
    5. cis-acting DNA from fission yeast centromeres mediates histone H3 methylation and recruitment of silencing factors and cohesin to an ectopic site. Partridge JF, et al. Curr Biol, 2002 Oct 1. PMID 12361567

    See all (53) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Aco2 antagonizes heterochromatic silencing by interfering with Chp1 binding to DNA.
      Title: Nuclear aconitase antagonizes heterochromatic silencing by interfering with Chp1 binding to DNA.
    2. Intrinsic nucleic acid-binding activity of Chp1 chromodomain is required for heterochromatic gene silencing
      Title: Intrinsic nucleic acid-binding activity of Chp1 chromodomain is required for heterochromatic gene silencing.
    3. The Chp1-Tas3 complex provides a solid and versatile platform to recruit both RNAi-dependent and RNAi-independent gene-silencing pathways for locus-specific regulation of heterochromatin.
      Title: The Chp1-Tas3 core is a multifunctional platform critical for gene silencing by RITS.
    4. Chp1's chromodomain contains extensive sites of contact that contribute to Chp1's high-affinity binding which is critical for the efficient establishment of centromeric heterochromatin.
      Title: High-affinity binding of Chp1 chromodomain to K9 methylated histone H3 is required to establish centromeric heterochromatin.
    5. findings suggest a pivotal role for Chp1 and its association with Tas3 for the recruitment of RITS, RDRC, and histone H3 K9 methyltransferase activity to centromeres
      Title: Chp1-Tas3 interaction is required to recruit RITS to fission yeast centromeres and for maintenance of centromeric heterochromatin.
    6. Chp1 associates with the mating type locus and telomeres interacting through its C-terminal domain with Tas3.
      Title: RNA interference (RNAi)-dependent and RNAi-independent association of the Chp1 chromodomain protein with distinct heterochromatic loci in fission yeast.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables chromatin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables histone binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone reader activity EXP
    Inferred from Experiment
    more info
    		 PubMed 
    enables histone reader activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables methylated histone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    NOT enables nuclease activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables single-stranded RNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in heterochromatin formation EXP
    Inferred from Experiment
    more info
    		 PubMed 
    involved_in heterochromatin formation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in pericentric heterochromatin formation EXP
    Inferred from Experiment
    more info
    		 PubMed 
    involved_in pericentric heterochromatin formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in siRNA-mediated pericentric heterochromatin formation EXP
    Inferred from Experiment
    more info
    		 PubMed 
    involved_in siRNA-mediated pericentric heterochromatin formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in silent mating-type cassette heterochromatin formation EXP
    Inferred from Experiment
    more info
    		 PubMed 
    involved_in silent mating-type cassette heterochromatin formation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in silent mating-type cassette heterochromatin formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in subtelomeric heterochromatin formation EXP
    Inferred from Experiment
    more info
    		 PubMed 
    involved_in subtelomeric heterochromatin formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of RITS complex EXP
    Inferred from Experiment
    more info
    		 PubMed 
    part_of RITS complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in condensed chromosome, centromeric region IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in heterochromatin island IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in mating-type region heterochromatin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus HDA PubMed 
    is_active_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in pericentric heterochromatin IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in pericentric heterochromatin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in subtelomeric heterochromatin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    heterochromatin (HP1) family chromodomain protein Chp1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003424.3 Reference assembly

      Range
      2210810..2214345 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001019098.3 → NP_593666.1  heterochromatin (HP1) family chromodomain protein Chp1 [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_593666.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      Q10103
      Conserved Domains (3) summary
      smart00298
      Location:21 → 64
      CHROMO; Chromatin organization modifier domain
      COG0724
      Location:224 → 371
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd00590
      Location:313 → 373
      RRM_SF; RNA recognition motif (RRM) superfamily
    Nucleotide Protein
    Heading Accession and Version

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