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    SLC37A4 solute carrier family 37 member 4 [ Homo sapiens (human) ]

    Gene ID: 2542, updated on 8-Jul-2021

    Summary

    Official Symbol
    SLC37A4provided by HGNC
    Official Full Name
    solute carrier family 37 member 4provided by HGNC
    Primary source
    HGNC:HGNC:4061
    See related
    Ensembl:ENSG00000137700 MIM:602671
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    G6PT1; G6PT2; G6PT3; GSD1b; GSD1c; GSD1d; TRG19; TRG-19; PRO0685
    Summary
    This gene regulates glucose-6-phosphate transport from the cytoplasm to the lumen of the endoplasmic reticulum, in order to maintain glucose homeostasis. It also plays a role in ATP-mediated calcium sequestration in the lumen of the endoplasmic reticulum. Mutations in this gene have been associated with various forms of glycogen storage disease. Alternative splicing in this gene results in multiple transcript variants.[provided by RefSeq, Aug 2009]
    Expression
    Broad expression in kidney (RPKM 40.6), duodenum (RPKM 31.3) and 24 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See SLC37A4 in Genome Data Viewer
    Location:
    11q23.3
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    109.20210514 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (119024112..119030877, complement)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (118894822..118901587, complement)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene centrosomal AT-AC splicing factor Neighboring gene ribosomal protein L23a pseudogene 64 Neighboring gene ribosomal protein S25 Neighboring gene trafficking protein particle complex subunit 4 Neighboring gene hypoxia up-regulated 1 Neighboring gene VPS11 core subunit of CORVET and HOPS complexes

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC15729

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    involved_in carbohydrate transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in gluconeogenesis TAS
    Traceable Author Statement
    more info
     
    involved_in glucose metabolic process NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in glucose-6-phosphate transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in glucose-6-phosphate transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in glucose-6-phosphate transport NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in phosphate ion transmembrane transport IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    glucose-6-phosphate exchanger SLC37A4
    Names
    glucose-5-phosphate transporter
    glucose-6-phosphatase, transport (glucose) protein 3
    glucose-6-phosphatase, transport (glucose-6-phosphate) protein 1
    glucose-6-phosphatase, transport (phosphate/pyrophosphate) protein 2
    glucose-6-phosphate translocase
    microsomal glucose-6-phosphate transporter
    solute carrier family 37 (glucose-6-phosphate transporter), member 4
    transformation-related gene 19 protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_013331.1 RefSeqGene

      Range
      5001..11555
      Download
      GenBank, FASTA, Sequence Viewer (Graphics), LRG_187

    mRNA and Protein(s)

    1. NM_001164277.2NP_001157749.1  glucose-6-phosphate exchanger SLC37A4 isoform 1

      See identical proteins and their annotated locations for NP_001157749.1

      Status: REVIEWED

      Source sequence(s)
      AP003392, FP885832
      UniProtKB/Swiss-Prot
      O43826
      UniProtKB/TrEMBL
      A0A024R3H9, A8K0S7
      Related
      ENST00000525102.5
      Conserved Domains (1) summary
      TIGR00881
      Location:18397
      2A0104; phosphoglycerate transporter family protein
    2. NM_001164278.2NP_001157750.1  glucose-6-phosphate exchanger SLC37A4 isoform 2

      See identical proteins and their annotated locations for NP_001157750.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) contains an alternate exon in the 5' UTR and an alternate in-frame exon in the 3' coding region, compared to variant 1. This results in a longer protein (isoform 2), compared to isoform 1.
      Source sequence(s)
      AP003392, FP885832
      UniProtKB/Swiss-Prot
      O43826
      UniProtKB/TrEMBL
      A0A024R3L1
      Related
      ENSP00000476176.2, ENST00000357590.9
      Conserved Domains (2) summary
      cd06174
      Location:14437
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
      TIGR00881
      Location:18419
      2A0104; phosphoglycerate transporter family protein
    3. NM_001164279.2NP_001157751.1  glucose-6-phosphate exchanger SLC37A4 isoform 3

      See identical proteins and their annotated locations for NP_001157751.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and uses a downstream translational start codon, compared to variant 1. This results in a shorter protein (isoform 3), compared to isoform 1.
      Source sequence(s)
      AP003392, FP885832
      UniProtKB/Swiss-Prot
      O43826
      UniProtKB/TrEMBL
      B4DUH2
      Related
      ENSP00000475991.2, ENST00000538950.5
      Conserved Domains (1) summary
      cd06174
      Location:4342
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    4. NM_001164280.2NP_001157752.1  glucose-6-phosphate exchanger SLC37A4 isoform 1

      See identical proteins and their annotated locations for NP_001157752.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR, compared to variant 1. Variants 1, 4, and 5 encode the same protein (isoform 1).
      Source sequence(s)
      AP003392, FP885832
      UniProtKB/Swiss-Prot
      O43826
      UniProtKB/TrEMBL
      A0A024R3H9
      Conserved Domains (1) summary
      TIGR00881
      Location:18397
      2A0104; phosphoglycerate transporter family protein
    5. NM_001467.6NP_001458.1  glucose-6-phosphate exchanger SLC37A4 isoform 1

      See identical proteins and their annotated locations for NP_001458.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR, compared to variant 1. Variants 1, 4, and 5 encode the same protein (isoform 1).
      Source sequence(s)
      AP003392, FP885832
      UniProtKB/Swiss-Prot
      O43826
      UniProtKB/TrEMBL
      A0A024R3H9
      Related
      ENST00000527992.5
      Conserved Domains (1) summary
      TIGR00881
      Location:18397
      2A0104; phosphoglycerate transporter family protein

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

      Range
      119024112..119030877 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh38.p13 PATCHES

    Genomic

    1. NW_009646203.1 Reference GRCh38.p13 PATCHES

      Range
      45712..52476 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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