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    LCLAT1 lysocardiolipin acyltransferase 1 [ Homo sapiens (human) ]

    Gene ID: 253558, updated on 3-Apr-2024

    Summary

    Official Symbol
    LCLAT1provided by HGNC
    Official Full Name
    lysocardiolipin acyltransferase 1provided by HGNC
    Primary source
    HGNC:HGNC:26756
    See related
    Ensembl:ENSG00000172954 MIM:614241; AllianceGenome:HGNC:26756
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    LYCAT; AGPAT8; ALCAT1; LPLAT6; 1AGPAT8; UNQ1849; HSRG1849
    Summary
    Enables 1-acylglycerol-3-phosphate O-acyltransferase activity. Predicted to be involved in phosphatidylinositol acyl-chain remodeling. Located in cytosol and endoplasmic reticulum. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in thyroid (RPKM 4.7), duodenum (RPKM 3.7) and 25 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See LCLAT1 in Genome Data Viewer
    Location:
    2p23.1
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (30447246..30644225)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (30491581..30688529)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (30670112..30867091)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15536 Neighboring gene uncharacterized LOC102723594 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15537 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:30517185-30517355 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:30523745-30524427 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:30524428-30525109 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:30525110-30525792 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:30525793-30526473 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15540 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15539 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15538 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15541 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15542 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15543 Neighboring gene long intergenic non-protein coding RNA 1936 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:30633050-30633962 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15544 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:30666124-30666624 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:30669802-30670539 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:30670540-30671276 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:30738762-30739262 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:30739263-30739763 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr2:30835819-30836816 Neighboring gene MPRA-validated peak3643 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15548 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr2:30874941-30875672 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:30875673-30876403 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11329 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:30943850-30944350 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:30944351-30944851 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:30988245-30988745 Neighboring gene calpain 13 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:31020137-31020846 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:31020847-31021554 Neighboring gene uncharacterized LOC124905982 Neighboring gene uncharacterized LOC105374435

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ37965

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables 1-acylglycerol-3-phosphate O-acyltransferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables 1-acylglycerol-3-phosphate O-acyltransferase activity TAS
    Traceable Author Statement
    more info
     
    enables O-acyltransferase activity TAS
    Traceable Author Statement
    more info
     
    enables acyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in CDP-diacylglycerol biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cardiolipin acyl-chain remodeling TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in phosphatidic acid biosynthetic process TAS
    Traceable Author Statement
    more info
     
    involved_in phosphatidylinositol acyl-chain remodeling IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
     
    is_active_in endomembrane system IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in endoplasmic reticulum membrane TAS
    Traceable Author Statement
    more info
     
    located_in membrane HDA PubMed 

    General protein information

    Preferred Names
    lysocardiolipin acyltransferase 1
    Names
    1-AGP acyltransferase 8
    1-AGPAT 8
    1-acylglycerol-3-phosphate O-acyltransferase 8
    1ysophospholipid acyltransferase 6
    acyl-CoA:lysocardiolipin acyltransferase 1
    NP_001002257.1
    NP_001291374.1
    NP_001291375.1
    NP_872357.2
    XP_005264301.1
    XP_005264302.1
    XP_011531043.1
    XP_016859235.1
    XP_016859236.1
    XP_047299824.1
    XP_047299825.1
    XP_054197237.1
    XP_054197238.1
    XP_054197239.1
    XP_054197240.1
    XP_054197241.1
    XP_054197242.1
    XP_054197243.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001002257.3NP_001002257.1  lysocardiolipin acyltransferase 1 isoform 2

      See identical proteins and their annotated locations for NP_001002257.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' structure, and uses a downstream start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus compared to isoform 1. Variants 2 and 4 encode the same isoform.
      Source sequence(s)
      AC132154, BC146817, BX537607
      Consensus CDS
      CCDS42670.1
      UniProtKB/TrEMBL
      B4DYR5
      Related
      ENSP00000368823.3, ENST00000379509.8
      Conserved Domains (3) summary
      cd07990
      Location:55248
      LPLAT_LCLAT1-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like
      PRK14014
      Location:7286
      PRK14014; putative acyltransferase; Provisional
      pfam16076
      Location:234306
      Acyltransf_C; Acyltransferase C-terminus
    2. NM_001304445.2NP_001291374.1  lysocardiolipin acyltransferase 1 isoform 2

      See identical proteins and their annotated locations for NP_001291374.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' structure, and uses a downstream start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus compared to isoform 1. Variants 2 and 4 encode the same isoform.
      Source sequence(s)
      AC073255, AC132154, AK302562, BX537607
      Consensus CDS
      CCDS42670.1
      UniProtKB/TrEMBL
      B4DYR5
      Conserved Domains (3) summary
      cd07990
      Location:55248
      LPLAT_LCLAT1-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like
      PRK14014
      Location:7286
      PRK14014; putative acyltransferase; Provisional
      pfam16076
      Location:234306
      Acyltransf_C; Acyltransferase C-terminus
    3. NM_001304446.2NP_001291375.1  lysocardiolipin acyltransferase 1 isoform 3

      See identical proteins and their annotated locations for NP_001291375.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' structure, and uses a downstream start codon, compared to variant 1. The encoded isoform (3) has a shorter N-terminus compared to isoform 1.
      Source sequence(s)
      AC132154, AK297262, BX537607
      UniProtKB/TrEMBL
      B4DM26
      Conserved Domains (2) summary
      cd07990
      Location:1124
      LPLAT_LCLAT1-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like
      pfam16076
      Location:110182
      Acyltransf_C; Acyltransferase C-terminus
    4. NM_182551.5NP_872357.2  lysocardiolipin acyltransferase 1 isoform 1

      See identical proteins and their annotated locations for NP_872357.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AC132154, AY358702, BP872689, BX537607
      Consensus CDS
      CCDS1772.1
      UniProtKB/Swiss-Prot
      A6H8Z7, Q6UWP7, Q8N1Q7
      UniProtKB/TrEMBL
      B4DYR5
      Related
      ENSP00000310551.4, ENST00000309052.8
      Conserved Domains (3) summary
      cd07990
      Location:93286
      LPLAT_LCLAT1-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like
      PRK14014
      Location:45324
      PRK14014; putative acyltransferase; Provisional
      pfam16076
      Location:272344
      Acyltransf_C; Acyltransferase C-terminus

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

      Range
      30447246..30644225
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005264245.4XP_005264302.1  lysocardiolipin acyltransferase 1 isoform X2

      See identical proteins and their annotated locations for XP_005264302.1

      UniProtKB/TrEMBL
      B4DYR5
      Conserved Domains (3) summary
      cd07990
      Location:55248
      LPLAT_LCLAT1-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like
      PRK14014
      Location:7286
      PRK14014; putative acyltransferase; Provisional
      pfam16076
      Location:234306
      Acyltransf_C; Acyltransferase C-terminus
    2. XM_005264244.2XP_005264301.1  lysocardiolipin acyltransferase 1 isoform X1

      See identical proteins and their annotated locations for XP_005264301.1

      UniProtKB/Swiss-Prot
      A6H8Z7, Q6UWP7, Q8N1Q7
      UniProtKB/TrEMBL
      B4DYR5
      Conserved Domains (3) summary
      cd07990
      Location:93286
      LPLAT_LCLAT1-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like
      PRK14014
      Location:45324
      PRK14014; putative acyltransferase; Provisional
      pfam16076
      Location:272344
      Acyltransf_C; Acyltransferase C-terminus
    3. XM_047443868.1XP_047299824.1  lysocardiolipin acyltransferase 1 isoform X2

    4. XM_017003746.2XP_016859235.1  lysocardiolipin acyltransferase 1 isoform X2

      UniProtKB/TrEMBL
      B4DYR5
      Conserved Domains (3) summary
      cd07990
      Location:55248
      LPLAT_LCLAT1-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like
      PRK14014
      Location:7286
      PRK14014; putative acyltransferase; Provisional
      pfam16076
      Location:234306
      Acyltransf_C; Acyltransferase C-terminus
    5. XM_047443869.1XP_047299825.1  lysocardiolipin acyltransferase 1 isoform X3

      Related
      ENSP00000368826.1, ENST00000319406.8
    6. XM_017003747.3XP_016859236.1  lysocardiolipin acyltransferase 1 isoform X4

    7. XM_011532741.3XP_011531043.1  lysocardiolipin acyltransferase 1 isoform X1

      See identical proteins and their annotated locations for XP_011531043.1

      UniProtKB/Swiss-Prot
      A6H8Z7, Q6UWP7, Q8N1Q7
      UniProtKB/TrEMBL
      B4DYR5
      Conserved Domains (3) summary
      cd07990
      Location:93286
      LPLAT_LCLAT1-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like
      PRK14014
      Location:45324
      PRK14014; putative acyltransferase; Provisional
      pfam16076
      Location:272344
      Acyltransf_C; Acyltransferase C-terminus

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060926.1 Alternate T2T-CHM13v2.0

      Range
      30491581..30688529
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054341268.1XP_054197243.1  lysocardiolipin acyltransferase 1 isoform X2

    2. XM_054341262.1XP_054197237.1  lysocardiolipin acyltransferase 1 isoform X1

      UniProtKB/Swiss-Prot
      A6H8Z7, Q6UWP7, Q8N1Q7
    3. XM_054341264.1XP_054197239.1  lysocardiolipin acyltransferase 1 isoform X2

    4. XM_054341265.1XP_054197240.1  lysocardiolipin acyltransferase 1 isoform X2

    5. XM_054341266.1XP_054197241.1  lysocardiolipin acyltransferase 1 isoform X3

    6. XM_054341267.1XP_054197242.1  lysocardiolipin acyltransferase 1 isoform X4

    7. XM_054341263.1XP_054197238.1  lysocardiolipin acyltransferase 1 isoform X1

      UniProtKB/Swiss-Prot
      A6H8Z7, Q6UWP7, Q8N1Q7