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    Grhl2 grainyhead like transcription factor 2 [ Mus musculus (house mouse) ]

    Gene ID: 252973, updated on 26-Feb-2019

    Summary

    Official Symbol
    Grhl2provided by MGI
    Official Full Name
    grainyhead like transcription factor 2provided by MGI
    Primary source
    MGI:MGI:2182543
    See related
    Ensembl:ENSMUSG00000022286
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    BOM; clft3; Tcfcp2l3; 0610015A08Rik
    Expression
    Biased expression in genital fat pad adult (RPKM 7.3), bladder adult (RPKM 5.9) and 14 other tissues See more
    Orthologs

    Genomic context

    See Grhl2 in Genome Data Viewer
    Location:
    15; 15 B3.1
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 15 NC_000081.6 (37232821..37363569)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 15 NC_000081.5 (37162791..37293324)

    Chromosome 15 - NC_000081.6Genomic Context describing neighboring genes Neighboring gene lactate dehydrogenase A pseudogene Neighboring gene predicted gene, 41303 Neighboring gene predicted gene 16136 Neighboring gene RIKEN cDNA 4930447A16 gene Neighboring gene neurocalcin delta Neighboring gene predicted gene 15941 Neighboring gene nucleus accumbens-associated protein 1 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (3) 
    • Targeted (2)  1 citation
    • Chemically induced (ENU) (2)  1 citation
    • Endonuclease-mediated (1) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    DNA binding ISA
    Inferred from Sequence Alignment
    more info
    PubMed 
    DNA-binding transcription activator activity, RNA polymerase II-specific ISO
    Inferred from Sequence Orthology
    more info
     
    DNA-binding transcription factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    DNA-binding transcription factor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    DNA-binding transcription factor activity ISA
    Inferred from Sequence Alignment
    more info
    PubMed 
    chromatin DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    chromatin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    intronic transcription regulatory region sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    bicellular tight junction assembly ISO
    Inferred from Sequence Orthology
    more info
     
    brain development IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    brain development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    camera-type eye development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cardiac ventricle morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cell adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    cell junction assembly ISO
    Inferred from Sequence Orthology
    more info
     
    cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    embryonic cranial skeleton morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    embryonic digit morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    embryonic organ development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    epidermis development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    epidermis development ISO
    Inferred from Sequence Orthology
    more info
     
    epithelial cell morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    epithelial cell morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    epithelial cell morphogenesis involved in placental branching IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    epithelium migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    face development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    in utero embryonic development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    lung epithelial cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    lung lobe morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    multicellular organism growth IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of keratinocyte differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    neural tube closure IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    neural tube development IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    neural tube development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of telomerase activity ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of transcription, DNA-templated IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of DNA methylation ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    regulation of transcription, DNA-templated ISA
    Inferred from Sequence Alignment
    more info
    PubMed 
    respiratory tube development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    cell-cell junction ISO
    Inferred from Sequence Orthology
    more info
     
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    grainyhead-like protein 2 homolog
    Names
    brother of mammalian grainyhead
    grainyhead like 2
    grainyhead-like 2
    grainyheadlike
    transcription factor CP2-like 3

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_026496.4NP_080772.2  grainyhead-like protein 2 homolog

      See identical proteins and their annotated locations for NP_080772.2

      Status: VALIDATED

      Source sequence(s)
      BC055035, BY018142, BY703140, CJ322576
      Consensus CDS
      CCDS27434.1
      UniProtKB/Swiss-Prot
      Q8K5C0
      Related
      ENSMUSP00000022895.8, ENSMUST00000022895.14
      Conserved Domains (1) summary
      pfam04516
      Location:229438
      CP2; CP2 transcription factor

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000081.6 Reference GRCm38.p4 C57BL/6J

      Range
      37232821..37363569
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006520063.3XP_006520126.2  grainyhead-like protein 2 homolog isoform X1

    2. XM_017316621.1XP_017172110.1  grainyhead-like protein 2 homolog isoform X2

    3. XM_017316622.1XP_017172111.1  grainyhead-like protein 2 homolog isoform X3

    4. XM_017316623.1XP_017172112.1  grainyhead-like protein 2 homolog isoform X4

    5. XM_006520065.3XP_006520128.1  grainyhead-like protein 2 homolog isoform X5

      See identical proteins and their annotated locations for XP_006520128.1

      UniProtKB/TrEMBL
      Q9DCN4
      Related
      ENSMUSP00000125410.1, ENSMUST00000161405.7
      Conserved Domains (1) summary
      pfam04516
      Location:229419
      CP2; CP2 transcription factor
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