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    Mios meiosis regulator for oocyte development [ Mus musculus (house mouse) ]

    Gene ID: 252875, updated on 31-Jan-2019

    Summary

    Official Symbol
    Miosprovided by MGI
    Official Full Name
    meiosis regulator for oocyte developmentprovided by MGI
    Primary source
    MGI:MGI:2182066
    See related
    Ensembl:ENSMUSG00000042447
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    C81488
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 5.0), CNS E14 (RPKM 4.0) and 27 other tissues See more
    Orthologs

    Genomic context

    See Mios in Genome Data Viewer
    Location:
    6; 6 A1
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 6 NC_000072.6 (8208992..8236274)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 6 NC_000072.5 (8159227..8186274)

    Chromosome 6 - NC_000072.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 35446 Neighboring gene ribonucleic acid binding protein S1 pseudogene Neighboring gene collagen, type XXVIII, alpha 1 Neighboring gene predicted gene, 35384 Neighboring gene predicted gene, 46951 Neighboring gene replication protein A3

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Pathways from BioSystems

    • mTOR signaling pathway, organism-specific biosystem (from KEGG)
      mTOR signaling pathway, organism-specific biosystemThe mammalian (mechanistic) target of rapamycin (mTOR) is a highly conserved serine/threonine protein kinase, which exists in two complexes termed mTOR complex 1 (mTORC1) and 2 (mTORC2). mTORC1 conta...
    • mTOR signaling pathway, conserved biosystem (from KEGG)
      mTOR signaling pathway, conserved biosystemThe mammalian (mechanistic) target of rapamycin (mTOR) is a highly conserved serine/threonine protein kinase, which exists in two complexes termed mTOR complex 1 (mTORC1) and 2 (mTORC2). mTORC1 conta...

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC25527

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    molecular_function ND
    No biological Data available
    more info
     
    Process Evidence Code Pubs
    cellular protein-containing complex localization ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to amino acid starvation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of TOR signaling ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    GATOR2 complex ISO
    Inferred from Sequence Orthology
    more info
     
    cell junction ISO
    Inferred from Sequence Orthology
    more info
     
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    lysosomal membrane ISO
    Inferred from Sequence Orthology
    more info
     
    lysosome IEA
    Inferred from Electronic Annotation
    more info
     
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    GATOR complex protein MIOS; WD repeat-containing protein mio
    Names
    missing oocyte, meiosis regulator, homolog

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_145374.2NP_663349.2  GATOR complex protein MIOS

      See identical proteins and their annotated locations for NP_663349.2

      Status: VALIDATED

      Source sequence(s)
      AK034623, AK079844, BP765255, BQ876300, BU510538, BY064617, CD807728, CX565910
      Consensus CDS
      CCDS39425.1
      UniProtKB/Swiss-Prot
      Q8VE19
      UniProtKB/TrEMBL
      Q8BV62
      Related
      ENSMUSP00000039301.7, ENSMUST00000040017.7
      Conserved Domains (4) summary
      COG2319
      Location:97368
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:64105
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:83297
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      cl24077
      Location:737858
      Zn_ribbon_17; Zinc-ribbon, C4HC2 type

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000072.6 Reference GRCm38.p4 C57BL/6J

      Range
      8208992..8236274
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006505086.3XP_006505149.1  WD repeat-containing protein mio isoform X1

      See identical proteins and their annotated locations for XP_006505149.1

      UniProtKB/Swiss-Prot
      Q8VE19
      Conserved Domains (4) summary
      COG2319
      Location:97368
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:64105
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:83297
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      cl24077
      Location:737858
      Zn_ribbon_17; Zinc-ribbon, C4HC2 type
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