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    Usp7 ubiquitin specific peptidase 7 [ Mus musculus (house mouse) ]

    Gene ID: 252870, updated on 12-Sep-2021

    Summary

    Official Symbol
    Usp7provided by MGI
    Official Full Name
    ubiquitin specific peptidase 7provided by MGI
    Primary source
    MGI:MGI:2182061
    See related
    Ensembl:ENSMUSG00000022710
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Hausp; C80752; AA409944; AA617399; AU019296; AW548146; 2210010O09Rik
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 25.2), liver E14 (RPKM 24.8) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Usp7 in Genome Data Viewer
    Location:
    16; 16 A1
    Exon count:
    34
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (8506586..8574931, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (8688722..8757067, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 16 NC_000082.5 (8688815..8738435, complement)

    Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene transmembrane protein 186 Neighboring gene phosphomannomutase 2 Neighboring gene calcium regulated heat stable protein 1 Neighboring gene predicted gene 5767 Neighboring gene predicted gene, 25805 Neighboring gene RIKEN cDNA 1810013L24 gene Neighboring gene predicted gene, 52232

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables Lys48-specific deubiquitinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables cysteine-type endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables cysteine-type endopeptidase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables cysteine-type endopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables cysteine-type peptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables deubiquitinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables p53 binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables peptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein C-terminus binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables thiol-dependent deubiquitinase IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables thiol-dependent deubiquitinase IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables thiol-dependent deubiquitinase IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables thiol-dependent deubiquitinase ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    enables transcription factor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables ubiquitin protein ligase binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within DNA repair IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within cellular response to DNA damage stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in histone H2B conserved C-terminal lysine deubiquitination IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in maintenance of DNA methylation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within monoubiquitinated protein deubiquitination ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    acts_upstream_of_or_within multicellular organism development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of NF-kappaB transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of proteasomal ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of DNA demethylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein K63-linked deubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein deubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in protein deubiquitination IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in protein deubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein stabilization ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within proteolysis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of DNA-binding transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of circadian rhythm IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of circadian rhythm ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of gluconeogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of protein stability IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in regulation of protein stability IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of protein stability ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of retrograde transport, endosome to Golgi ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within rhythmic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in transcription-coupled nucleotide-excision repair ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in ubiquitin-dependent protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in XY body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    ubiquitin carboxyl-terminal hydrolase 7
    Names
    deubiquitinating enzyme 7
    herpesvirus-associated ubiquitin-specific protease
    mHAUSP
    ubiquitin specific protease 7
    ubiquitin thioesterase 7
    ubiquitin thiolesterase 7
    ubiquitin-specific-processing protease 7
    NP_001003918.2
    XP_006522201.1
    XP_006522202.1
    XP_006522204.1
    XP_030104976.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001003918.2NP_001003918.2  ubiquitin carboxyl-terminal hydrolase 7

      See identical proteins and their annotated locations for NP_001003918.2

      Status: VALIDATED

      Source sequence(s)
      AC115005, AC156026, AF548565, AK135814
      Consensus CDS
      CCDS49755.1
      UniProtKB/Swiss-Prot
      Q6A4J8
      UniProtKB/TrEMBL
      F8VPX1
      Related
      ENSMUSP00000124093.3, ENSMUST00000161046.9
      Conserved Domains (5) summary
      COG5077
      Location:561101
      COG5077; Ubiquitin carboxyl-terminal hydrolase [Posttranslational modification, protein turnover, chaperones]
      cd02659
      Location:213524
      peptidase_C19C; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      cd03772
      Location:68203
      MATH_HAUSP; Herpesvirus-associated ubiquitin-specific protease (HAUSP, also known as USP7) family, N-terminal MATH (TRAF-like) domain; composed of proteins similar to human HAUSP, an enzyme that specifically catalyzes the deubiquitylation of p53 and MDM2, hence ...
      pfam12436
      Location:621866
      USP7_ICP0_bdg; ICP0-binding domain of Ubiquitin-specific protease 7
      pfam14533
      Location:8761087
      USP7_C2; Ubiquitin-specific protease C-terminal

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000082.7 Reference GRCm39 C57BL/6J

      Range
      8506586..8574931 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006522138.4XP_006522201.1  ubiquitin carboxyl-terminal hydrolase 7 isoform X1

      UniProtKB/TrEMBL
      E9PXY8
      Related
      ENSMUSP00000124382.2, ENSMUST00000160405.8
      Conserved Domains (1) summary
      COG5077
      Location:961141
      COG5077; Ubiquitin carboxyl-terminal hydrolase [Posttranslational modification, protein turnover, chaperones]
    2. XM_006522141.4XP_006522204.1  ubiquitin carboxyl-terminal hydrolase 7 isoform X3

      Conserved Domains (1) summary
      COG5077
      Location:61001
      COG5077; Ubiquitin carboxyl-terminal hydrolase [Posttranslational modification, protein turnover, chaperones]
    3. XM_030249116.2XP_030104976.1  ubiquitin carboxyl-terminal hydrolase 7 isoform X3

      Conserved Domains (1) summary
      COG5077
      Location:61001
      COG5077; Ubiquitin carboxyl-terminal hydrolase [Posttranslational modification, protein turnover, chaperones]
    4. XM_006522139.4XP_006522202.1  ubiquitin carboxyl-terminal hydrolase 7 isoform X2

      Conserved Domains (1) summary
      COG5077
      Location:391084
      COG5077; Ubiquitin carboxyl-terminal hydrolase [Posttranslational modification, protein turnover, chaperones]
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