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    Th tyrosine hydroxylase [ Rattus norvegicus (Norway rat) ]

    Gene ID: 25085, updated on 10-Jul-2024

    Summary

    Official Symbol
    Thprovided by RGD
    Official Full Name
    tyrosine hydroxylaseprovided by RGD
    Primary source
    RGD:3853
    See related
    EnsemblRapid:ENSRNOG00000020410 AllianceGenome:RGD:3853
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    The
    Summary
    Enables several functions, including cation binding activity; tetrahydrobiopterin binding activity; and tyrosine 3-monooxygenase activity. Involved in several processes, including aminergic neurotransmitter loading into synaptic vesicle; carboxylic acid metabolic process; and cellular response to nicotine. Located in several cellular components, including cytoplasmic vesicle; perikaryon; and terminal bouton. Used to study Parkinson's disease. Biomarker of several diseases, including brain disease (multiple); hyperprolactinemia; hypoglycemia; polycystic ovary syndrome; and portal hypertension. Human ortholog(s) of this gene implicated in Parkinson's disease; Parkinsonism; hypertension; and obesity. Orthologous to human TH (tyrosine hydroxylase). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Restricted expression toward (RPKM 273.3) See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Location:
    1q41
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (207500959..207508276, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (198071500..198078832, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (216073034..216080287, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene vegetative cell wall protein gp1-like Neighboring gene insulin-like growth factor 2 Neighboring gene insulin 2 Neighboring gene uncharacterized LOC108349673 Neighboring gene uncharacterized LOC120099959 Neighboring gene achaete-scute family bHLH transcription factor 2 Neighboring gene tetraspanin 32

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables amino acid binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables amino acid binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables dopamine binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables enzyme binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables ferric iron binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables ferrous iron binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables identical protein binding TAS
    Traceable Author Statement
    more info
    PubMed 
    enables iron ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables monooxygenase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables oxygen binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein domain specific binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables small molecule binding EXP
    Inferred from Experiment
    more info
    PubMed 
    enables small molecule binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables tetrahydrobiopterin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables tyrosine 3-monooxygenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables tyrosine 3-monooxygenase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables tyrosine 3-monooxygenase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables tyrosine 3-monooxygenase activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in aminergic neurotransmitter loading into synaptic vesicle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within animal organ morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in aromatic amino acid metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in catecholamine biosynthetic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cellular response to alkaloid IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in cellular response to glucose stimulus IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in cellular response to growth factor stimulus IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in cellular response to manganese ion IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in cellular response to nicotine IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in cellular response to xenobiotic stimulus IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in cerebral cortex development IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in circadian sleep/wake cycle IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in cognition IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in dopamine biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in dopamine biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in dopamine biosynthetic process from tyrosine IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in dopamine biosynthetic process from tyrosine IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in dopamine biosynthetic process from tyrosine IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within dopamine biosynthetic process from tyrosine ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within eating behavior ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in embryonic camera-type eye morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in epinephrine biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in eye photoreceptor cell development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in fatty acid metabolic process IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in glycoside metabolic process IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in heart development IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in heart development IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within heart development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in hyaloid vascular plexus regression ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in hyaloid vascular plexus regression ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in isoquinoline alkaloid metabolic process IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    acts_upstream_of_or_within learning ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within locomotory behavior ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within mating behavior ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within memory ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in norepinephrine biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in phthalate metabolic process IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in phytoalexin metabolic process IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    acts_upstream_of_or_within regulation of heart contraction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to activity IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to amphetamine IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to corticosterone IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to electrical stimulus IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to estradiol IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to ethanol IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in response to ethanol IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to ethanol ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to ether IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to growth factor IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to herbicide IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to hypoxia IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in response to hypoxia IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in response to hypoxia IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to hypoxia ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to immobilization stress IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to insecticide IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to isolation stress IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to light stimulus IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to lipopolysaccharide IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to metal ion IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to nicotine IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to nutrient levels IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to organic cyclic compound IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to peptide hormone IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to pyrethroid IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to salt stress IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to steroid hormone IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to xenobiotic stimulus IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to zinc ion IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in social behavior IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in sphingolipid metabolic process IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    acts_upstream_of_or_within synaptic transmission, dopaminergic ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in terpene metabolic process IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in visual perception ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    is_active_in axon IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in axon IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in axon ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasmic side of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasmic vesicle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasmic vesicle membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in dendrite IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in melanosome membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in neuron projection ISO
    Inferred from Sequence Orthology
    more info
     
    located_in neuron projection terminus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in neuronal cell body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in perikaryon IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in perikaryon IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in perikaryon ISO
    Inferred from Sequence Orthology
    more info
     
    located_in perinuclear region of cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in perinuclear region of cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in smooth endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    located_in synaptic vesicle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in synaptic vesicle IEA
    Inferred from Electronic Annotation
    more info
     
    located_in terminal bouton IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    tyrosine 3-monooxygenase
    Names
    tyrosine 3-hydroxylase
    NP_036872.1
    XP_038957255.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_012740.4NP_036872.1  tyrosine 3-monooxygenase

      See identical proteins and their annotated locations for NP_036872.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/Swiss-Prot
      P04177
      UniProtKB/TrEMBL
      A6HY86
      Related
      ENSRNOP00000108930.1, ENSRNOT00000163405.1
      Conserved Domains (3) summary
      cd04930
      Location:38158
      ACT_TH; ACT domain of the nonheme iron-dependent aromatic amino acid hydroxylase, tyrosine hydroxylases (TH)
      pfam00351
      Location:165495
      Biopterin_H; Biopterin-dependent aromatic amino acid hydroxylase
      pfam12549
      Location:226
      TOH_N; Tyrosine hydroxylase N terminal

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      207500959..207508276 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039101327.2XP_038957255.1  tyrosine 3-monooxygenase isoform X1

      UniProtKB/TrEMBL
      A0A8I6AXT4
      Related
      ENSRNOP00000093950.1, ENSRNOT00000105945.2
      Conserved Domains (3) summary
      pfam00351
      Location:132462
      Biopterin_H; Biopterin-dependent aromatic amino acid hydroxylase
      pfam12549
      Location:226
      TOH_N; Tyrosine hydroxylase N terminal
      cl09141
      Location:38125
      ACT; ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme

    RNA

    1. XR_010063580.1 RNA Sequence