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    Klk1c2 kallikrein 1-related peptidase C2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 24841, updated on 10-Jul-2024

    Summary

    Official Symbol
    Klk1c2provided by RGD
    Official Full Name
    kallikrein 1-related peptidase C2provided by RGD
    Primary source
    RGD:3888
    See related
    EnsemblRapid:ENSRNOG00000068685 AllianceGenome:RGD:3888
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Ton; KLK2; Klna1; rGK-2
    Summary
    Enables serine-type peptidase activity. Predicted to be involved in regulation of systemic arterial blood pressure and zymogen activation. Predicted to be active in secretory granule. Human ortholog(s) of this gene implicated in cardiomyopathy; chronic kidney disease; end stage renal disease; hypertension; and myocardial infarction. Orthologous to human KLK1 (kallikrein 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Kidney (RPKM 18.2), Testes (RPKM 9.8) and 1 other tissue See more
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    Genomic context

    See Klk1c2 in Genome Data Viewer
    Location:
    1q22
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (103628854..103633000, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (94492332..94496480, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (99981045..99985422, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene kallikrein 1-related peptidase C6 Neighboring gene kallikrein related-peptidase 5 like, pseudogene 1 Neighboring gene kallikrein-related peptidase 15, pseudogene 3 Neighboring gene kallikrein-2-like

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    Related articles in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables serine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables serine-type peptidase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of systemic arterial blood pressure IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in zymogen activation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    is_active_in secretory granule IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    tonin
    Names
    RSKG-5
    S2 kallikrein
    esterase 1
    glandular kallikrein-2
    kallikrein a1
    NP_036809.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_012677.1NP_036809.1  tonin precursor

      See identical proteins and their annotated locations for NP_036809.1

      Status: PROVISIONAL

      Source sequence(s)
      M11565
      UniProtKB/Swiss-Prot
      P00759
      UniProtKB/TrEMBL
      A0A0G2JX00, A0A1R3UCJ3
      Related
      ENSRNOP00000081904.1, ENSRNOT00000107012.2
      Conserved Domains (1) summary
      smart00020
      Location:24251
      Tryp_SPc; Trypsin-like serine protease

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      103628854..103633000 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)