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    Pomc proopiomelanocortin [ Rattus norvegicus (Norway rat) ]

    Gene ID: 24664, updated on 10-Jul-2024

    Summary

    Official Symbol
    Pomcprovided by RGD
    Official Full Name
    proopiomelanocortinprovided by RGD
    Primary source
    RGD:3366
    See related
    EnsemblRapid:ENSRNOG00000012686 AllianceGenome:RGD:3366
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Pomc1; Pomc2; alphaMSH
    Summary
    Predicted to enable hormone activity and melanocortin receptor binding activity. Predicted to be involved in several processes, including cortisol secretion; positive regulation of cAMP-mediated signaling; and regulation of gene expression. Predicted to act upstream of or within several processes, including calcium-mediated signaling; glucose homeostasis; and regulation of glycogen metabolic process. Located in extracellular region. Human ortholog(s) of this gene implicated in familial Mediterranean fever; obesity; and osteoarthritis. Orthologous to human POMC (proopiomelanocortin). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Testes (RPKM 25.0), Kidney (RPKM 15.8) and 9 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Pomc in Genome Data Viewer
    Location:
    6q14
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (32659137..32665175)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (26939844..26945666)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (28382937..28388771)

    Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene DNA methyltransferase 3 alpha Neighboring gene uncharacterized LOC120103494 Neighboring gene Yip1 domain family, member 4 like 1 Neighboring gene EFR3 homolog B Neighboring gene uncharacterized LOC120103495 Neighboring gene DnaJ heat shock protein family (Hsp40) member C27 Neighboring gene cytochrome c oxidase subunit 7B, pseudogene 3

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables G protein-coupled receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables G protein-coupled receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables hormone activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables hormone activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables signaling receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables type 1 melanocortin receptor binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables type 1 melanocortin receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables type 3 melanocortin receptor binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables type 3 melanocortin receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables type 4 melanocortin receptor binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables type 4 melanocortin receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in calcium-mediated signaling IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within calcium-mediated signaling ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cell-cell signaling IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cell-cell signaling ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular pigmentation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular pigmentation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cortisol secretion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in feeding behavior NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in generation of precursor metabolites and energy IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in generation of precursor metabolites and energy ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in glucose homeostasis IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within glucose homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of tumor necrosis factor production IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of tumor necrosis factor production ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in neuropeptide signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of neutrophil mediated killing of fungus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of oxytocin production IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of oxytocin production ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of appetite IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of appetite ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of blood pressure IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within regulation of blood pressure ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of corticosterone secretion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of corticosterone secretion IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within regulation of corticosterone secretion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of glycogen metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within regulation of glycogen metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to alcohol IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to ethanol IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to immobilization stress ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to melanocyte-stimulating hormone IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to melanocyte-stimulating hormone ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in extracellular region IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
     
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
     
    located_in peroxisomal matrix ISO
    Inferred from Sequence Orthology
    more info
     
    NOT located_in peroxisome ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in secretory granule IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in secretory granule IEA
    Inferred from Electronic Annotation
    more info
     
    located_in secretory granule ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    pro-opiomelanocortin
    Names
    alpha-melanocyte-stimulating hormone
    corticotropin-lipotropin
    pro-opiomelanocortin-alpha
    proopiomelanocortin (adrenocorticotropin/ beta-lipotropin/ alpha-melanocyte stimulating hormone/ beta-melanocyte stimulating hormone/ beta-endorphin)
    proopiomelanocortin, beta (endorphin, beta)
    proopoimelanocortin, beta (endorphin, beta)

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_139326.3NP_647542.1  pro-opiomelanocortin precursor

      See identical proteins and their annotated locations for NP_647542.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000006
      UniProtKB/Swiss-Prot
      P01194
      UniProtKB/TrEMBL
      A6HAG6, F6PTD9, Q8K422
      Related
      ENSRNOP00000016976.5, ENSRNOT00000016976.9
      Conserved Domains (3) summary
      pfam00976
      Location:186204
      ACTH_domain; Corticotropin ACTH domain
      pfam08035
      Location:205232
      Op_neuropeptide; Opioids neuropeptide
      pfam08384
      Location:2870
      NPP; Pro-opiomelanocortin, N-terminal region

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086024.1 Reference GRCr8

      Range
      32659137..32665175
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017594033.3XP_017449522.1  pro-opiomelanocortin isoform X1

      UniProtKB/Swiss-Prot
      P01194
      UniProtKB/TrEMBL
      A6HAG6, F6PTD9, Q8K422
      Conserved Domains (3) summary
      pfam00976
      Location:186204
      ACTH_domain; Corticotropin ACTH domain
      pfam08035
      Location:205232
      Op_neuropeptide; Opioids neuropeptide
      pfam08384
      Location:2870
      NPP; Pro-opiomelanocortin, N-terminal region
    2. XM_063261551.1XP_063117621.1  pro-opiomelanocortin isoform X1

      UniProtKB/Swiss-Prot
      P01194
      UniProtKB/TrEMBL
      A6HAG6, F6PTD9, Q8K422