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    Klhl8 kelch-like 8 [ Mus musculus (house mouse) ]

    Gene ID: 246293, updated on 28-Aug-2018

    Summary

    Official Symbol
    Klhl8provided by MGI
    Official Full Name
    kelch-like 8provided by MGI
    Primary source
    MGI:MGI:2179430
    See related
    Ensembl:ENSMUSG00000029312 Vega:OTTMUSG00000022027
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    D5Ertd431e; 2310001P09Rik
    Expression
    Broad expression in CNS E18 (RPKM 14.2), whole brain E14.5 (RPKM 10.2) and 23 other tissues See more
    Orthologs

    Genomic context

    See Klhl8 in Genome Data Viewer
    Location:
    5 E5; 5 50.45 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 5 NC_000071.6 (103862050..103911272, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 5 NC_000071.5 (104291069..104340248, complement)

    Chromosome 5 - NC_000071.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 42138 Neighboring gene AF4/FMR2 family, member 1 Neighboring gene predicted gene, 42139 Neighboring gene hydroxysteroid (17-beta) dehydrogenase 13 Neighboring gene hydroxysteroid (17-beta) dehydrogenase 11

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Targeted (2) 

    General gene information

    Markers

    Homology

    Clone Names

    • MGC102224

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    protein ubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    Cul3-RING ubiquitin ligase complex ISO
    Inferred from Sequence Orthology
    more info
     
    nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001359986.1NP_001346915.1  kelch-like protein 8

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. All three variants encode the same protein.
      Source sequence(s)
      AL731554
      Conserved Domains (3) summary
      smart00612
      Location:564609
      Kelch; Kelch domain
      PHA03098
      Location:69544
      PHA03098; kelch-like protein; Provisional
      sd00038
      Location:365408
      Kelch; KELCH repeat [structural motif]
    2. NM_001359987.1NP_001346916.1  kelch-like protein 8

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. All three variants encode the same protein.
      Source sequence(s)
      AL731554
      Conserved Domains (3) summary
      smart00612
      Location:564609
      Kelch; Kelch domain
      PHA03098
      Location:69544
      PHA03098; kelch-like protein; Provisional
      sd00038
      Location:365408
      Kelch; KELCH repeat [structural motif]
    3. NM_178741.4NP_848856.1  kelch-like protein 8

      See identical proteins and their annotated locations for NP_848856.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. All three variants encode the same protein.
      Source sequence(s)
      AK031028, BY250847
      Consensus CDS
      CCDS19479.1
      UniProtKB/Swiss-Prot
      P59280
      Related
      ENSMUSP00000031254.2, OTTMUSP00000024768, ENSMUST00000031254.8
      Conserved Domains (3) summary
      smart00612
      Location:564609
      Kelch; Kelch domain
      PHA03098
      Location:69544
      PHA03098; kelch-like protein; Provisional
      sd00038
      Location:365408
      Kelch; KELCH repeat [structural motif]

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000071.6 Reference GRCm38.p4 C57BL/6J

      Range
      103862050..103911272 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006534942.3XP_006535005.1  kelch-like protein 8 isoform X1

      UniProtKB/Swiss-Prot
      P59280
      Conserved Domains (3) summary
      smart00612
      Location:564609
      Kelch; Kelch domain
      PHA03098
      Location:69544
      PHA03098; kelch-like protein; Provisional
      sd00038
      Location:365408
      Kelch; KELCH repeat [structural motif]
    2. XM_017320883.1XP_017176372.1  kelch-like protein 8 isoform X1

      UniProtKB/Swiss-Prot
      P59280
      Conserved Domains (3) summary
      smart00612
      Location:564609
      Kelch; Kelch domain
      PHA03098
      Location:69544
      PHA03098; kelch-like protein; Provisional
      sd00038
      Location:365408
      Kelch; KELCH repeat [structural motif]
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