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    Npy neuropeptide Y [ Rattus norvegicus (Norway rat) ]

    Gene ID: 24604, updated on 10-Jul-2024

    Summary

    Symbol
    Npyprovided by RGD
    Full Name
    neuropeptide Yprovided by RGD
    Primary source
    RGD:3197
    See related
    EnsemblRapid:ENSRNOG00000046449 AllianceGenome:RGD:3197
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    NPY02; RATNPY; RATNPY02
    Summary
    This gene encodes a neuropeptide that is widely expressed in the central nervous system and influences many physiological processes, including cortical excitability, stress response, food intake, circadian rhythms, and cardiovascular function. Studies in the rat model of depression (Flinders Sensitive Line) show that this gene is downregulated in the hippocampus and the prefrontal cortex compared to the control ((Flinders Resistant Line). Alternatively spliced transcript variants of this gene have been described, but the function of all the variants is not known. [provided by RefSeq, Jul 2012]
    Expression
    Biased expression in Spleen (RPKM 232.5), Brain (RPKM 130.5) and 6 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Npy in Genome Data Viewer
    Location:
    4q24
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (80212111..80219310)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (78881294..78888495)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (79557856..79565059)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene RGD1564712 Neighboring gene uncharacterized LOC134486578 Neighboring gene uncharacterized LOC102555694 Neighboring gene basic proline-rich protein-like Neighboring gene protein associated with LIN7 2, MAGUK p55 family member

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables G protein-coupled receptor binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables G protein-coupled receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables hormone activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables neuropeptide Y receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables neuropeptide Y receptor binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables neuropeptide hormone activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in adult feeding behavior IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in antimicrobial humoral immune response mediated by antimicrobial peptide ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in central nervous system neuron development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in central nervous system neuron development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cerebral cortex development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cerebral cortex development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in chemical synaptic transmission IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in feeding behavior IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in innate immune response ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in monocyte activation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of acute inflammatory response to antigenic stimulus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of blood pressure IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of somatostatin secretion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in neuron projection development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in neuron projection development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in neuropeptide signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in neuropeptide signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of ERK1 and ERK2 cascade IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of appetite IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of cell population proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of cell-substrate adhesion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of dopamine metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of eating behavior IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of nitric oxide metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of somatostatin secretion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of blood pressure IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within regulation of blood pressure ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of nerve growth factor production IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of presynaptic cytosolic calcium ion concentration EXP
    Inferred from Experiment
    more info
    PubMed 
    involved_in regulation of presynaptic cytosolic calcium ion concentration IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of synaptic vesicle exocytosis EXP
    Inferred from Experiment
    more info
    PubMed 
    involved_in regulation of synaptic vesicle exocytosis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in short-day photoperiodism IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in synaptic signaling via neuropeptide IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in synaptic signaling via neuropeptide ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in GABA-ergic synapse IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in GABA-ergic synapse ISO
    Inferred from Sequence Orthology
    more info
     
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
     
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in neuronal dense core vesicle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in neuronal dense core vesicle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in neuronal dense core vesicle IEA
    Inferred from Electronic Annotation
    more info
     
    located_in perikaryon IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in perinuclear region of cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in synapse ISO
    Inferred from Sequence Orthology
    more info
     
    located_in terminal bouton IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    pro-neuropeptide Y
    Names
    pro-neuropeptide Y-like

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_012614.2NP_036746.1  pro-neuropeptide Y preproprotein

      See identical proteins and their annotated locations for NP_036746.1

      Status: REVIEWED

      Source sequence(s)
      JAXUCZ010000004, M20373
      UniProtKB/Swiss-Prot
      P07808
      UniProtKB/TrEMBL
      F2W8A6, F2W8A7, M0RAZ3
      Related
      ENSRNOP00000066713.4, ENSRNOT00000074351.4
      Conserved Domains (1) summary
      smart00309
      Location:3065
      PAH; Pancreatic hormones / neuropeptide F / peptide YY family

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      80212111..80219310
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)