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    Ankrd27 ankyrin repeat domain 27 (VPS9 domain) [ Mus musculus (house mouse) ]

    Gene ID: 245886, updated on 31-Jan-2019

    Summary

    Official Symbol
    Ankrd27provided by MGI
    Official Full Name
    ankyrin repeat domain 27 (VPS9 domain)provided by MGI
    Primary source
    MGI:MGI:2444103
    See related
    Ensembl:ENSMUSG00000034867
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Varp; AA408090; BC016493; D330003H11Rik
    Expression
    Ubiquitous expression in limb E14.5 (RPKM 10.8), bladder adult (RPKM 7.7) and 28 other tissues See more
    Orthologs

    Genomic context

    See Ankrd27 in Genome Data Viewer
    Location:
    7; 7 B2
    Exon count:
    29
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 7 NC_000073.6 (35586226..35639237)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 7 NC_000073.5 (36371266..36424256)

    Chromosome 7 - NC_000073.6Genomic Context describing neighboring genes Neighboring gene nudix (nucleoside diphosphate linked moiety X)-type motif 19 Neighboring gene regulator of G-protein signalling 9 binding protein Neighboring gene programmed cell death 5 Neighboring gene predicted gene, 42379

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Targeted (2) 

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC25907

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    GTPase activator activity IEA
    Inferred from Electronic Annotation
    more info
     
    Rab GTPase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Rab GTPase binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Rab GTPase binding ISO
    Inferred from Sequence Orthology
    more info
     
    SNARE binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    SNARE binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    guanyl-nucleotide exchange factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    guanyl-nucleotide exchange factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    early endosome to late endosome transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    early endosome to late endosome transport ISO
    Inferred from Sequence Orthology
    more info
     
    endosome to melanosome transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of SNARE complex assembly ISO
    Inferred from Sequence Orthology
    more info
     
    neuron projection morphogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    neuron projection morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of dendrite morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of neuron projection development ISO
    Inferred from Sequence Orthology
    more info
     
    protein transport IEA
    Inferred from Electronic Annotation
    more info
     
    retrograde transport, endosome to plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    retrograde transport, endosome to plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    cell ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasmic vesicle IEA
    Inferred from Electronic Annotation
    more info
     
    early endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    early endosome ISO
    Inferred from Sequence Orthology
    more info
     
    endosome IEA
    Inferred from Electronic Annotation
    more info
     
    late endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    late endosome ISO
    Inferred from Sequence Orthology
    more info
     
    lysosome ISO
    Inferred from Sequence Orthology
    more info
     
    melanosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    neuron projection IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    neuron projection IDA
    Inferred from Direct Assay
    more info
    PubMed 
    plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    transport vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    transport vesicle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    tubular endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    tubular endosome ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    ankyrin repeat domain-containing protein 27
    Names
    VPS9 domain-containing protein
    VPS9-ankyrin repeat-containing protein
    VPS9-ankyrin-repeat protein
    mFLJ00040 protein

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001358876.1NP_001345805.1  ankyrin repeat domain-containing protein 27 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC151531
      Conserved Domains (4) summary
      cd00204
      Location:722847
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      sd00045
      Location:764791
      ANK; ANK repeat [structural motif]
      cl19569
      Location:264363
      VPS9; Vacuolar sorting protein 9 (VPS9) domain
      cl26073
      Location:559625
      Ank_2; Ankyrin repeats (3 copies)
    2. NM_145633.3NP_663608.3  ankyrin repeat domain-containing protein 27 isoform 1

      See identical proteins and their annotated locations for NP_663608.3

      Status: VALIDATED

      Source sequence(s)
      AK144733, BC065093, BY070464, BY376293
      Consensus CDS
      CCDS21154.1
      UniProtKB/Swiss-Prot
      Q3UMR0
      Related
      ENSMUSP00000041751.9, ENSMUST00000040844.15
      Conserved Domains (4) summary
      cd00204
      Location:737862
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam12796
      Location:780872
      Ank_2; Ankyrin repeats (3 copies)
      sd00045
      Location:779806
      ANK; ANK repeat [structural motif]
      cl19569
      Location:264363
      VPS9; Vacuolar sorting protein 9 (VPS9) domain
    3. NM_178263.3NP_839994.1  ankyrin repeat domain-containing protein 27 isoform 2

      See identical proteins and their annotated locations for NP_839994.1

      Status: VALIDATED

      Source sequence(s)
      AI429389, AK085796, AK144733, BY070464
      Consensus CDS
      CCDS80706.1
      UniProtKB/Swiss-Prot
      Q3UMR0
      UniProtKB/TrEMBL
      A0A0R4J2C4
      Related
      ENSMUSP00000140554.1, ENSMUST00000186245.6
      Conserved Domains (1) summary
      cl19569
      Location:264363
      VPS9; Vacuolar sorting protein 9 (VPS9) domain

    RNA

    1. NR_152519.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC151531

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000073.6 Reference GRCm38.p4 C57BL/6J

      Range
      35586226..35639237
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006539985.2XP_006540048.1  ankyrin repeat domain-containing protein 27 isoform X2

      Related
      ENSMUSP00000140259.1, ENSMUST00000190503.6
      Conserved Domains (4) summary
      cd00204
      Location:722847
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      sd00045
      Location:764791
      ANK; ANK repeat [structural motif]
      cl19569
      Location:264363
      VPS9; Vacuolar sorting protein 9 (VPS9) domain
      cl26073
      Location:559625
      Ank_2; Ankyrin repeats (3 copies)
    2. XM_017322264.1XP_017177753.1  ankyrin repeat domain-containing protein 27 isoform X1

    3. XM_006539986.2XP_006540049.1  ankyrin repeat domain-containing protein 27 isoform X3

      Conserved Domains (5) summary
      cd00204
      Location:700825
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam12796
      Location:743835
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:528569
      Ank_4; Ankyrin repeats (many copies)
      sd00045
      Location:742769
      ANK; ANK repeat [structural motif]
      cl19569
      Location:227326
      VPS9; Vacuolar sorting protein 9 (VPS9) domain
    4. XM_017322266.1XP_017177755.1  ankyrin repeat domain-containing protein 27 isoform X4

    RNA

    1. XR_881721.2 RNA Sequence

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