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    Polr2h polymerase (RNA) II (DNA directed) polypeptide H [ Mus musculus (house mouse) ]

    Gene ID: 245841, updated on 8-Jul-2021

    Summary

    Official Symbol
    Polr2hprovided by MGI
    Official Full Name
    polymerase (RNA) II (DNA directed) polypeptide Hprovided by MGI
    Primary source
    MGI:MGI:2384309
    See related
    Ensembl:ENSMUSG00000021018
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 18.5), limb E14.5 (RPKM 12.7) and 27 other tissues See more
    Orthologs
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    Genomic context

    See Polr2h in Genome Data Viewer
    Location:
    16; 16 B1
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (20536576..20541022)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (20717826..20722272)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 16 NC_000082.5 (20717899..20722338)

    Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene eukaryotic translation initiation factor 4, gamma 1 Neighboring gene small nucleolar RNA, C/D box 66 Neighboring gene family with sequence similarity 131, member A Neighboring gene chloride channel, voltage-sensitive 2 Neighboring gene thrombopoietin Neighboring gene chordin Neighboring gene predicted gene, 22741

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC8248, MGC103049

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables DNA-directed 5'-3' RNA polymerase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables single-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    part_of RNA polymerase I complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of RNA polymerase II, core complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of RNA polymerase II, core complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of RNA polymerase III complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    part_of protein-DNA complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    DNA-directed RNA polymerases I, II, and III subunit RPABC3
    Names
    DNA-directed RNA polymerase II subunit H
    RNA polymerases I, II, and III subunit ABC3
    RPB17
    RPB8 homolog
    NP_001343352.1
    NP_663607.1
    XP_030104975.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001356423.1NP_001343352.1  DNA-directed RNA polymerases I, II, and III subunit RPABC3 isoform 2

      Status: VALIDATED

      Source sequence(s)
      CT010490
      Related
      ENSMUSP00000155920.2, ENSMUST00000161038.2
      Conserved Domains (1) summary
      smart00658
      Location:1111
      RPOL8c; RNA polymerase subunit 8
    2. NM_145632.2NP_663607.1  DNA-directed RNA polymerases I, II, and III subunit RPABC3 isoform 1

      See identical proteins and their annotated locations for NP_663607.1

      Status: VALIDATED

      Source sequence(s)
      CT010490
      Consensus CDS
      CCDS28058.1
      UniProtKB/Swiss-Prot
      Q923G2
      Related
      ENSMUSP00000021405.8, ENSMUST00000021405.8
      Conserved Domains (1) summary
      smart00658
      Location:2147
      RPOL8c; RNA polymerase subunit 8

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000082.7 Reference GRCm39 C57BL/6J

      Range
      20536576..20541022
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030249115.2XP_030104975.1  DNA-directed RNA polymerases I, II, and III subunit RPABC3 isoform X1

      Related
      ENSMUSP00000155967.2, ENSMUST00000231392.2
      Conserved Domains (1) summary
      pfam03870
      Location:18140
      RNA_pol_Rpb8; RNA polymerase Rpb8
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