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    Rbbp7 retinoblastoma binding protein 7, chromatin remodeling factor [ Mus musculus (house mouse) ]

    Gene ID: 245688, updated on 26-Sep-2022

    Summary

    Official Symbol
    Rbbp7provided by MGI
    Official Full Name
    retinoblastoma binding protein 7, chromatin remodeling factorprovided by MGI
    Primary source
    MGI:MGI:1194910
    See related
    Ensembl:ENSMUSG00000031353 AllianceGenome:MGI:1194910
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    mRbAp46
    Summary
    Enables RNA binding activity. Acts upstream of or within negative regulation of transcription by RNA polymerase II. Located in nucleus. Part of ESC/E(Z) complex and NuRD complex. Is expressed in several structures, including alimentary system; brain; early embryo; genitourinary system; and hemolymphoid system. Orthologous to human RBBP7 (RB binding protein 7, chromatin remodeling factor). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in placenta adult (RPKM 217.3), liver E18 (RPKM 180.1) and 21 other tissues See more
    Orthologs
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    Genomic context

    See Rbbp7 in Genome Data Viewer
    Location:
    X; X F4
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) X NC_000086.8 (161543368..161562086)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (162760372..162779090)

    Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene predicted gene 15201 Neighboring gene predicted gene, 23786 Neighboring gene taxilin gamma Neighboring gene pyruvate kinase, muscle pseudogene Neighboring gene predicted gene, 23901

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables histone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables histone binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within DNA replication IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in brain development IC
    Inferred by Curator
    more info
    PubMed 
    involved_in cellular heat acclimation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular heat acclimation ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    acts_upstream_of_or_within chromatin organization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in chromatin remodeling IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in chromatin remodeling ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within chromatin remodeling TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in histone deacetylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in histone deacetylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of DNA-templated transcription IC
    Inferred by Curator
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of cell growth ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of cell migration IC
    Inferred by Curator
    more info
    PubMed 
    involved_in negative regulation of stem cell population maintenance IC
    Inferred by Curator
    more info
    PubMed 
    involved_in negative regulation of transcription by RNA polymerase II IC
    Inferred by Curator
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of transforming growth factor beta receptor signaling pathway IC
    Inferred by Curator
    more info
    PubMed 
    involved_in positive regulation of DNA-templated transcription IC
    Inferred by Curator
    more info
    PubMed 
    involved_in positive regulation of stem cell population maintenance IC
    Inferred by Curator
    more info
    PubMed 
    involved_in regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of cell fate specification IC
    Inferred by Curator
    more info
    PubMed 
    involved_in regulation of stem cell differentiation IC
    Inferred by Curator
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of ATPase complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of ESC/E(Z) complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of ESC/E(Z) complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of ESC/E(Z) complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of NURF complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of NuRD complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of NuRD complex IC
    Inferred by Curator
    more info
    PubMed 
    part_of NuRD complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of NuRD complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of Sin3 complex IC
    Inferred by Curator
    more info
    PubMed 
    located_in chromosome, telomeric region ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    part_of histone deacetylase complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in nucleus IC
    Inferred by Curator
    more info
    PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    histone-binding protein RBBP7
    Names
    G1/S transition control protein-binding protein
    RBBP-7
    histone acetyltransferase type B subunit 2
    nucleosome-remodeling factor subunit RBAP46
    retinoblastoma-binding protein 7
    retinoblastoma-binding protein p46

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_009031.3NP_033057.3  histone-binding protein RBBP7

      See identical proteins and their annotated locations for NP_033057.3

      Status: VALIDATED

      Source sequence(s)
      AK078349, AK135779, CA556887
      Consensus CDS
      CCDS30509.1
      UniProtKB/Swiss-Prot
      Q3UX20, Q60973
      UniProtKB/TrEMBL
      A0A6P5P3S0, Q8C5H3
      Related
      ENSMUSP00000033720.6, ENSMUST00000033720.12
      Conserved Domains (3) summary
      sd00039
      Location:127174
      7WD40; WD40 repeat [structural motif]
      pfam12265
      Location:1887
      CAF1C_H4-bd; Histone-binding protein RBBP4 or subunit C of CAF1 complex
      cl29593
      Location:122402
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000086.8 Reference GRCm39 C57BL/6J

      Range
      161543368..161562086
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030251353.1XP_030107213.1  histone-binding protein RBBP7 isoform X1

      UniProtKB/TrEMBL
      Q3UX53
      Conserved Domains (3) summary
      sd00039
      Location:93140
      7WD40; WD40 repeat [structural motif]
      pfam12265
      Location:153
      CAF1C_H4-bd; Histone-binding protein RBBP4 or subunit C of CAF1 complex
      cl29593
      Location:88368
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...