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    Ivd isovaleryl-CoA dehydrogenase [ Rattus norvegicus (Norway rat) ]

    Gene ID: 24513, updated on 10-Jul-2024

    Summary

    Official Symbol
    Ivdprovided by RGD
    Official Full Name
    isovaleryl-CoA dehydrogenaseprovided by RGD
    Primary source
    RGD:2936
    See related
    EnsemblRapid:ENSRNOG00000009421 AllianceGenome:RGD:2936
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables identical protein binding activity and isovaleryl-CoA dehydrogenase activity. Involved in leucine catabolic process. Located in mitochondrial matrix and mitochondrial membrane. Human ortholog(s) of this gene implicated in amino acid metabolic disorder and isovaleric acidemia. Orthologous to human IVD (isovaleryl-CoA dehydrogenase). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Heart (RPKM 893.2), Adrenal (RPKM 714.9) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Ivd in Genome Data Viewer
    Location:
    3q35
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (126305584..126326016)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (105851710..105872144)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (110669355..110689789)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene dispatched RND transporter family member 2 Neighboring gene kinetochore-localized astrin/SPAG5 binding protein Neighboring gene uncharacterized LOC134486300 Neighboring gene bromo adjacent homology domain containing 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables acyl-CoA dehydrogenase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables butyryl-CoA dehydrogenase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables flavin adenine dinucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables isovaleryl-CoA dehydrogenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables isovaleryl-CoA dehydrogenase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables isovaleryl-CoA dehydrogenase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables short-chain fatty acyl-CoA dehydrogenase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in mitochondrial matrix IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in mitochondrial membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    isovaleryl-CoA dehydrogenase, mitochondrial
    Names
    butyryl-CoA dehydrogenase
    isovaleryl coenzyme A dehydrogenase
    NP_036724.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_012592.2NP_036724.1  isovaleryl-CoA dehydrogenase, mitochondrial precursor

      See identical proteins and their annotated locations for NP_036724.1

      Status: PROVISIONAL

      Source sequence(s)
      BC088401
      UniProtKB/Swiss-Prot
      P12007
      UniProtKB/TrEMBL
      A0A8I6A3D0, A6HPD3
      Related
      ENSRNOP00000013829.4, ENSRNOT00000013829.7
      Conserved Domains (2) summary
      cd01156
      Location:42421
      IVD; Isovaleryl-CoA dehydrogenase
      PLN02519
      Location:43417
      PLN02519; isovaleryl-CoA dehydrogenase

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      126305584..126326016
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)