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    Ins2 insulin 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 24506, updated on 10-Jul-2024

    Summary

    Symbol
    Ins2provided by RGD
    Full Name
    insulin 2provided by RGD
    Primary source
    RGD:2916
    See related
    EnsemblRapid:ENSRNOG00000020405 AllianceGenome:RGD:2916
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    CP-II
    Summary
    Predicted to enable several functions, including identical protein binding activity; signaling receptor binding activity; and zinc ion binding activity. Predicted to be involved in several processes, including negative regulation of catabolic process; positive regulation of macromolecule metabolic process; and positive regulation of signal transduction. Predicted to act upstream of or within several processes, including cell surface receptor signaling pathway; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress; and positive regulation of phosphorylation. Located in extracellular space. Colocalizes with secretory granule. Used to study hypertension. Biomarker of Alzheimer's disease. Human ortholog(s) of this gene implicated in diabetic retinopathy; glucose metabolism disease (multiple); insulinoma; and pancreatic cancer. Orthologous to human INS (insulin). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Spleen (RPKM 64.3), Liver (RPKM 16.5) and 1 other tissue See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Ins2 in Genome Data Viewer
    Location:
    1q41
    Exon count:
    39
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (207272738..207421998, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (197843277..197992522, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (215856967..215858034, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene vegetative cell wall protein gp1-like Neighboring gene microRNA 483 Neighboring gene insulin-like growth factor 2 Neighboring gene uncharacterized LOC108349673 Neighboring gene uncharacterized LOC120099959 Neighboring gene tyrosine hydroxylase

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables hormone activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables hormone activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables insulin receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables insulin receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables insulin-like growth factor receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protease binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables zinc ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in ER overload response IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within ER overload response ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in G protein-coupled receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in acute-phase response ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in alpha-beta T cell activation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in biological_process ND
    No biological Data available
    more info
     
    involved_in fatty acid homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in glucose homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in glucose homeostasis IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within glucose homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in glucose homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in glucose metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within glucose metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in glycoprotein biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in insulin processing IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in insulin processing ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in insulin receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within insulin receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in insulin receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in lactate biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in lipid biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in lipid catabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within lipid catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in lipoprotein biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in myoblast fusion IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within myoblast fusion ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within myotube differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of acute inflammatory response ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of fatty acid metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of feeding behavior ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of negative regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of gluconeogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of glycogen catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of lipid catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of protein secretion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of proteolysis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of reactive oxygen species biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of respiratory burst involved in inflammatory response ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in neuron projection maintenance ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in nitric oxide-cGMP-mediated signaling ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of DNA replication ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of ERK1 and ERK2 cascade IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within positive regulation of ERK1 and ERK2 cascade ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of MAPK cascade ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cytokine production ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of dendritic spine maintenance ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of fatty acid biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of glucose import ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of glucose metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of glycogen biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of glycolytic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of insulin receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of mitotic nuclear division ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of nitric oxide mediated signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of peptidyl-tyrosine phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within positive regulation of peptidyl-tyrosine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of protein autophosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of protein localization to nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of protein metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of protein secretion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of respiratory burst ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein hexamerization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in receptor internalization IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_positive_effect receptor internalization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of cellular amino acid metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of protein localization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of protein localization to plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of protein secretion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in vasodilation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in wound healing ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
     
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in secretory granule IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in secretory granule IEA
    Inferred from Electronic Annotation
    more info
     
    located_in secretory granule ISO
    Inferred from Sequence Orthology
    more info
     
    part_of sno(s)RNA-containing ribonucleoprotein complex IEA
    Inferred from Electronic Annotation
    more info
     
    part_of sno(s)RNA-containing ribonucleoprotein complex ISO
    Inferred from Sequence Orthology
    more info
     

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_019130.2NP_062003.1  insulin-2 preproprotein

      See identical proteins and their annotated locations for NP_062003.1

      Status: VALIDATED

      Source sequence(s)
      BP467629, BP472188, BP485158
      UniProtKB/Swiss-Prot
      P01323
      UniProtKB/TrEMBL
      A6HY81, A6JHT1
      Related
      ENSRNOP00000027656.1, ENSRNOT00000027656.5
      Conserved Domains (1) summary
      cd04367
      Location:26110
      IlGF_insulin_like; IlGF_like family, insulin_like subgroup, specific to vertebrates. Members include a number of peptides including insulin and insulin-like growth factors I and II, which play a variety of roles in controlling processes such as metabolism, growth and ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      207272738..207421998 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063280751.1XP_063136821.1  insulin-2 isoform X1

      UniProtKB/TrEMBL
      A0A8I6G4B8, A6JHT1

    RNA

    1. XR_010062670.1 RNA Sequence

    2. XR_010062672.1 RNA Sequence

    3. XR_010062674.1 RNA Sequence

    4. XR_010062701.1 RNA Sequence

    5. XR_010062666.1 RNA Sequence

    6. XR_010062665.1 RNA Sequence

    7. XR_010062697.1 RNA Sequence

    8. XR_010062695.1 RNA Sequence

    9. XR_010062699.1 RNA Sequence

    10. XR_010062669.1 RNA Sequence

    11. XR_010062667.1 RNA Sequence

    12. XR_010062703.1 RNA Sequence

    13. XR_010062671.1 RNA Sequence

    14. XR_010062673.1 RNA Sequence

    15. XR_010062692.1 RNA Sequence

    16. XR_010062679.1 RNA Sequence

    17. XR_010062709.1 RNA Sequence

    18. XR_010062705.1 RNA Sequence

    19. XR_010062689.1 RNA Sequence

    20. XR_010062675.1 RNA Sequence

    21. XR_010062682.1 RNA Sequence

    22. XR_010062678.1 RNA Sequence

    23. XR_010062684.1 RNA Sequence

    24. XR_010062685.1 RNA Sequence

    25. XR_010062681.1 RNA Sequence

    26. XR_010062680.1 RNA Sequence

    27. XR_010062668.1 RNA Sequence

    28. XR_010062704.1 RNA Sequence

    29. XR_010062676.1 RNA Sequence

    30. XR_010062686.1 RNA Sequence

    31. XR_010062712.1 RNA Sequence

    32. XR_010062715.1 RNA Sequence

    33. XR_010062710.1 RNA Sequence

    34. XR_010062714.1 RNA Sequence