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    Il6 interleukin 6 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 24498, updated on 10-Jul-2024

    Summary

    Official Symbol
    Il6provided by RGD
    Official Full Name
    interleukin 6provided by RGD
    Primary source
    RGD:2901
    See related
    EnsemblRapid:ENSRNOG00000010278 AllianceGenome:RGD:2901
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    ILg6; Ifnb2
    Summary
    Enables cytokine activity and interleukin-6 receptor binding activity. Involved in several processes, including cellular response to lipid; positive regulation of cell communication; and response to peptide hormone. Located in cytoplasm and extracellular space. Used to study several diseases, including acute necrotizing pancreatitis; disseminated intravascular coagulation; fatty liver disease; hypertension (multiple); and impotence. Biomarker of several diseases, including acute necrotizing pancreatitis; artery disease (multiple); auditory system disease (multiple); iron deficiency anemia; and lung disease (multiple). Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); eye disease (multiple); gastrointestinal system cancer (multiple); glucose metabolism disease (multiple); and periodontal disease (multiple). Orthologous to human IL6 (interleukin 6). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Spleen (RPKM 22.5) and Thymus (RPKM 3.4) See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Il6 in Genome Data Viewer
    Location:
    4q11
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (5889999..5894575, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (5214602..5219178, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (3043231..3047807)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene transmembrane p24 trafficking protein 10, pseudogene 1 Neighboring gene dihydrofolate reductase, pseudogene 1 Neighboring gene 60S ribosomal protein L34 pseudogene Neighboring gene DnaJ heat shock protein family (Hsp40) member B6 Neighboring gene uncharacterized LOC120102202

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables cytokine activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables cytokine activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables cytokine activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables cytokine activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables growth factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables growth factor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables growth factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables interleukin-6 receptor binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables interleukin-6 receptor binding IEA
    Inferred from Electronic Annotation
    more info
     
    contributes_to interleukin-6 receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables interleukin-6 receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables signaling receptor binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within T cell activation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in T follicular helper cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in T follicular helper cell differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in T-helper 17 cell lineage commitment ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in T-helper 17 cell lineage commitment ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of T-helper 2 cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in acute-phase response IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in bone remodeling IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    acts_upstream_of_or_within branching involved in salivary gland morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cell redox homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cellular response to cytokine stimulus IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in cellular response to dexamethasone stimulus IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in cellular response to estradiol stimulus IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    acts_upstream_of_or_within cellular response to hepatocyte growth factor stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to hydrogen peroxide IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in cellular response to hydrogen peroxide ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to interleukin-1 IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    acts_upstream_of_or_within cellular response to interleukin-1 ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to interleukin-17 ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to lipopolysaccharide IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    acts_upstream_of_or_within cellular response to lipopolysaccharide ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to nutrient levels IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in cellular response to prolactin IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in cellular response to tumor necrosis factor IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    acts_upstream_of_or_within cellular response to tumor necrosis factor ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to virus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to virus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in cytokine-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within defense response to protozoan ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in defense response to virus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in endocrine pancreas development ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within epithelial cell proliferation involved in salivary gland morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within_positive_effect gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in germinal center B cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in germinal center B cell differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in glucagon secretion ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within glucose homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in glucose homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in glucose homeostasis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in hepatic immune response ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in hepatocyte proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in hepatocyte proliferation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in immune response IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in inflammatory response ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in inflammatory response to wounding ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within interleukin-6-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in interleukin-6-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in interleukin-6-mediated signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in liver regeneration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in liver regeneration ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in lymphocyte costimulation IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    acts_upstream_of_or_within muscle cell cellular homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within myeloid cell homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of bone resorption ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of cell population proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of chemokine production ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of collagen biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of gluconeogenesis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of hormone secretion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of interleukin-1-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of membrane potential IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of muscle organ development IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of neuron apoptotic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of negative regulation of primary miRNA processing ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in neuron projection development ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within neutrophil apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in neutrophil apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of B cell activation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of DNA replication IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of ERK1 and ERK2 cascade IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of MAPK cascade ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of MAPK cascade ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of T cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of T-helper 2 cell cytokine production ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of T-helper 2 cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of acute inflammatory response ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of apoptotic DNA fragmentation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cell population proliferation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of cell proliferation in bone marrow ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of chemokine production ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cytokine production involved in inflammatory response ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of epithelial cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of epithelial to mesenchymal transition ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of estradiol secretion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of extracellular matrix disassembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of gene expression IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of glial cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of gliogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of immunoglobulin production ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of immunoglobulin production ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of interleukin-1 beta production ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of interleukin-10 production ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of interleukin-17 production ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of interleukin-21 production ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of interleukin-21 production ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of interleukin-6 production ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of interleukin-8 production ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of leukocyte adhesion to vascular endothelial cell ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of multicellular organismal process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of neuron differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of neuron projection development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of nitric oxide biosynthetic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of osteoblast differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of peptidyl-serine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of peptidyl-tyrosine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of positive regulation of platelet aggregation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of protein import into nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of receptor signaling pathway via JAK-STAT IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of receptor signaling pathway via JAK-STAT IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of receptor signaling pathway via JAK-STAT ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of positive regulation of receptor signaling pathway via STAT ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of receptor signaling pathway via STAT ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of smooth muscle cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of translation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of transmission of nerve impulse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of tumor necrosis factor production ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of tyrosine phosphorylation of STAT protein ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of vascular endothelial growth factor production ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of cell shape IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of circadian sleep/wake cycle, non-REM sleep IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of glucagon secretion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of glucagon secretion ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of insulin secretion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of insulin secretion ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of vascular endothelial growth factor production ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to Gram-positive bacterium IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in response to amino acid IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to auditory stimulus IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to bacterium IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to caffeine IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to calcium ion IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to cytokine IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to electrical stimulus IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to glucocorticoid ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to insulin IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to lipopolysaccharide IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to mechanical stimulus IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to nutrient levels IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to organic cyclic compound IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    acts_upstream_of_or_within response to wounding ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to xenobiotic stimulus IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to yeast IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in vascular endothelial growth factor production ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in vascular endothelial growth factor production ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    located_in external side of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
     
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
     
    part_of interleukin-6 receptor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of interleukin-6 receptor complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of interleukin-6 receptor complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    interleukin-6
    Names
    IL-6
    Interleukin 6 (interferon, beta 2)

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_012589.2NP_036721.1  interleukin-6 precursor

      See identical proteins and their annotated locations for NP_036721.1

      Status: PROVISIONAL

      Source sequence(s)
      M26744
      UniProtKB/Swiss-Prot
      P20607
      UniProtKB/TrEMBL
      A0A8I6A641, A6KJN3
      Related
      ENSRNOP00000013732.7, ENSRNOT00000013732.8
      Conserved Domains (1) summary
      cl02473
      Location:27210
      IL6; Interleukin-6/G-CSF/MGF family

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      5889999..5894575 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)