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    Sipa1l2 signal-induced proliferation-associated 1 like 2 [ Mus musculus (house mouse) ]

    Gene ID: 244668, updated on 7-Aug-2018

    Summary

    Official Symbol
    Sipa1l2provided by MGI
    Official Full Name
    signal-induced proliferation-associated 1 like 2provided by MGI
    Primary source
    MGI:MGI:2676970
    See related
    Ensembl:ENSMUSG00000001995 Vega:OTTMUSG00000061592
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    BC058408; mKIAA1389
    Expression
    Ubiquitous expression in adrenal adult (RPKM 20.0), lung adult (RPKM 16.6) and 24 other tissues See more
    Orthologs

    Genomic context

    See Sipa1l2 in Genome Data Viewer
    Location:
    8; 8 E2
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 8 NC_000074.6 (125418063..125569863, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 8 NC_000074.5 (127941963..128016610, complement)

    Chromosome 8 - NC_000074.6Genomic Context describing neighboring genes Neighboring gene disrupted in schizophrenia 1 Neighboring gene predicted gene, 30713 Neighboring gene RIKEN cDNA 4930567H12 gene Neighboring gene predicted gene, 30871

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Pathways from BioSystems

    • Rap1 signaling pathway, organism-specific biosystem (from KEGG)
      Rap1 signaling pathway, organism-specific biosystemRap1 is a small GTPase that controls diverse processes, such as cell adhesion, cell-cell junction formation and cell polarity. Like all G proteins, Rap1 cycles between an inactive GDP-bound and an ac...
    • Rap1 signaling pathway, conserved biosystem (from KEGG)
      Rap1 signaling pathway, conserved biosystemRap1 is a small GTPase that controls diverse processes, such as cell adhesion, cell-cell junction formation and cell polarity. Like all G proteins, Rap1 cycles between an inactive GDP-bound and an ac...

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    GTPase activator activity IEA
    Inferred from Electronic Annotation
    more info
     
    molecular_function ND
    No biological Data available
    more info
     
    Process Evidence Code Pubs
    biological_process ND
    No biological Data available
    more info
     
    regulation of small GTPase mediated signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    cellular_component ND
    No biological Data available
    more info
     

    General protein information

    Preferred Names
    signal-induced proliferation-associated 1-like protein 2
    Names
    SIPA1-like protein 2

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001081337.2NP_001074806.1  signal-induced proliferation-associated 1-like protein 2 isoform 1

      See identical proteins and their annotated locations for NP_001074806.1

      Status: VALIDATED

      Source sequence(s)
      AC073946
      Consensus CDS
      CCDS40518.1
      UniProtKB/Swiss-Prot
      Q80TE4
      Related
      ENSMUSP00000104405.1, ENSMUST00000108775.1
      Conserved Domains (3) summary
      cd00992
      Location:9511021
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam02145
      Location:626806
      Rap_GAP; Rap/ran-GAP
      pfam11881
      Location:14231666
      SPAR_C; C-terminal domain of SPAR protein
    2. NM_001357372.1NP_001344301.1  signal-induced proliferation-associated 1-like protein 2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      BB352643, BC072593, CJ105938
      Conserved Domains (4) summary
      cd00992
      Location:9511021
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam02145
      Location:626806
      Rap_GAP; Rap/ran-GAP
      pfam11881
      Location:14231648
      SPAR_C; C-terminal domain of SPAR protein
      pfam15742
      Location:16301694
      DUF4686; Domain of unknown function (DUF4686)

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000074.6 Reference GRCm38.p4 C57BL/6J

      Range
      125418063..125569863 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011248389.1XP_011246691.1  signal-induced proliferation-associated 1-like protein 2 isoform X3

      Conserved Domains (3) summary
      cd00992
      Location:9511021
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam02145
      Location:626806
      Rap_GAP; Rap/ran-GAP
      pfam11881
      Location:14231604
      SPAR_C; C-terminal domain of SPAR protein
    2. XM_006531025.1XP_006531088.1  signal-induced proliferation-associated 1-like protein 2 isoform X2

      UniProtKB/TrEMBL
      A0A1D5RLY9
      Related
      ENSMUSP00000148557.1, OTTMUSP00000077894, ENSMUST00000212168.1, OTTMUST00000150251
      Conserved Domains (4) summary
      cd00992
      Location:9511021
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam02145
      Location:626806
      Rap_GAP; Rap/ran-GAP
      pfam11881
      Location:14231648
      SPAR_C; C-terminal domain of SPAR protein
      pfam15742
      Location:16301694
      DUF4686; Domain of unknown function (DUF4686)
    3. XM_006531024.1XP_006531087.1  signal-induced proliferation-associated 1-like protein 2 isoform X1

      See identical proteins and their annotated locations for XP_006531087.1

      UniProtKB/Swiss-Prot
      Q80TE4
      Related
      ENSMUSP00000148536.1, OTTMUSP00000077895, ENSMUST00000212987.1, OTTMUST00000150252
      Conserved Domains (3) summary
      cd00992
      Location:9511021
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam02145
      Location:626806
      Rap_GAP; Rap/ran-GAP
      pfam11881
      Location:14231666
      SPAR_C; C-terminal domain of SPAR protein
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