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    Phlpp2 PH domain and leucine rich repeat protein phosphatase 2 [ Mus musculus (house mouse) ]

    Gene ID: 244650, updated on 29-Jun-2021

    Summary

    Official Symbol
    Phlpp2provided by MGI
    Official Full Name
    PH domain and leucine rich repeat protein phosphatase 2provided by MGI
    Primary source
    MGI:MGI:2444928
    See related
    Ensembl:ENSMUSG00000031732
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    P; Phlppl; AI481772; C130044A18Rik
    Expression
    Ubiquitous expression in large intestine adult (RPKM 7.7), small intestine adult (RPKM 6.5) and 27 other tissues See more
    Orthologs
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    Genomic context

    See Phlpp2 in Genome Data Viewer
    Location:
    8; 8 D3
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (110595149..110671303)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (109868517..109944671)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 8 NC_000074.5 (112392503..112468571)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene adaptor protein complex AP-1, gamma 1 subunit Neighboring gene predicted gene, 17344 Neighboring gene small nucleolar RNA, C/D box 71 Neighboring gene predicted gene, 25321 Neighboring gene MARVEL (membrane-associating) domain containing 3 Neighboring gene 40S ribosomal protein S24 pseudogene Neighboring gene tyrosine aminotransferase

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (3)  1 citation
    • Endonuclease-mediated (2) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • KIAA0931

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables phosphoprotein phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein serine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein serine/threonine phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables protein threonine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in intercellular bridge ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in intracellular membrane-bounded organelle IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in mitotic spindle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    PH domain leucine-rich repeat-containing protein phosphatase 2
    Names
    GTPase activating protein and VPS9 domains 1
    NP_001116066.2
    XP_006531073.1
    XP_030099411.1
    XP_036009935.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001122594.2NP_001116066.2  PH domain leucine-rich repeat-containing protein phosphatase 2

      See identical proteins and their annotated locations for NP_001116066.2

      Status: VALIDATED

      Source sequence(s)
      AC122807, AI481772, AK048472
      Consensus CDS
      CCDS57644.1
      UniProtKB/Swiss-Prot
      Q8BXA7
      UniProtKB/TrEMBL
      J3QM82
      Related
      ENSMUSP00000136166.2, ENSMUST00000179721.8
      Conserved Domains (5) summary
      cd00116
      Location:447714
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      cd00143
      Location:8161065
      PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...
      cd13322
      Location:181275
      PH_PHLPP-like; PH domain leucine-rich repeat protein phosphatase family Pleckstrin homology-like domain
      sd00033
      Location:514535
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:676735
      LRR_8; Leucine rich repeat

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      110595149..110671303
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006531010.4XP_006531073.1  PH domain leucine-rich repeat-containing protein phosphatase 2 isoform X2

      Conserved Domains (4) summary
      PLN00113
      Location:280758
      PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
      cd13322
      Location:181275
      PH_PHLPP-like; PH domain leucine-rich repeat protein phosphatase family Pleckstrin homology-like domain
      sd00033
      Location:514535
      LRR_RI; leucine-rich repeat [structural motif]
      cd17241
      Location:66174
      RA_PHLPP2; Ras-associating (RA) domain found in PH domain leucine-rich repeat-containing protein phosphatase 2 (PHLPP2)
    2. XM_036154042.1XP_036009935.1  PH domain leucine-rich repeat-containing protein phosphatase 2 isoform X1

      Conserved Domains (4) summary
      PLN00113
      Location:114592
      PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
      cd00143
      Location:650899
      PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...
      cd13322
      Location:15109
      PH_PHLPP-like; PH domain leucine-rich repeat protein phosphatase family Pleckstrin homology-like domain
      sd00033
      Location:348369
      LRR_RI; leucine-rich repeat [structural motif]
    3. XM_030243551.1XP_030099411.1  PH domain leucine-rich repeat-containing protein phosphatase 2 isoform X3

      Conserved Domains (3) summary
      PRK15370
      Location:12208
      PRK15370; type III secretion system effector E3 ubiquitin transferase SlrP
      cd00143
      Location:243492
      PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...
      sd00033
      Location:929
      LRR_RI; leucine-rich repeat [structural motif]
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