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    Kat6a K(lysine) acetyltransferase 6A [ Mus musculus (house mouse) ]

    Gene ID: 244349, updated on 23-Jun-2021

    Summary

    Official Symbol
    Kat6aprovided by MGI
    Official Full Name
    K(lysine) acetyltransferase 6Aprovided by MGI
    Primary source
    MGI:MGI:2442415
    See related
    Ensembl:ENSMUSG00000031540
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    MO; MOZ; Myst; Myst3; Zfp22; Zfp220; 1500036M03; 9930021N24Rik
    Expression
    Ubiquitous expression in thymus adult (RPKM 13.7), CNS E11.5 (RPKM 10.5) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Kat6a in Genome Data Viewer
    Location:
    8; 8 A2
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (23349458..23433275)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (22859442..22943259)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 8 NC_000074.5 (23970011..24053734)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 1700041G16 gene Neighboring gene adaptor-related protein complex 3, mu 2 subunit Neighboring gene predicted gene, 46036 Neighboring gene predicted gene, 24735 Neighboring gene mitochondrial ribosomal protein L4 pseudogene Neighboring gene LSM6 homolog, U6 small nuclear RNA associated pseudogene Neighboring gene ankyrin 1, erythroid Neighboring gene predicted gene 15816 Neighboring gene microRNA 3107 Neighboring gene microRNA 486

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables acetyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables acyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables chromatin binding IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    enables histone acetyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables histone acetyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables histone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables transcription coactivator activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables transcription coregulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables transcription factor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables zinc ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in animal organ development IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within aorta morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within aorta morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cellular senescence ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within chromatin organization IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within embryonic hemopoiesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within face morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within face morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within heart morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within heart morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in histone H3 acetylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within histone H3 acetylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in histone H3 acetylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in histone acetylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in myeloid cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within negative regulation of DNA-binding transcription factor activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of transcription, DNA-templated IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in negative regulation of transcription, DNA-templated ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in nucleosome assembly IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in positive regulation of transcription, DNA-templated ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein acetylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within somatic stem cell population maintenance IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of MOZ/MORF histone acetyltransferase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of MOZ/MORF histone acetyltransferase complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in PML body ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nuclear speck ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
     
    part_of nucleosome IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    histone acetyltransferase KAT6A
    Names
    MOZ, YBF2/SAS3, SAS2 and TIP60 protein 3
    MYST histone acetyltransferase (monocytic leukemia) 3
    histone acetyltransferase MYST3
    monocytic leukemia zinc finger homolog
    monocytic leukemia zinc finger protein
    zinc finger protein 220
    NP_001074618.1
    NP_001351378.1
    XP_006509176.1
    XP_017168283.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001081149.2NP_001074618.1  histone acetyltransferase KAT6A

      See identical proteins and their annotated locations for NP_001074618.1

      Status: VALIDATED

      Source sequence(s)
      AC115361, AC142414
      Consensus CDS
      CCDS40294.1
      UniProtKB/TrEMBL
      G3X940
      Related
      ENSMUSP00000038181.7, ENSMUST00000044331.7
      Conserved Domains (4) summary
      smart00526
      Location:85162
      H15; Domain in histone families 1 and 5
      cd15527
      Location:264310
      PHD2_KAT6A_6B; PHD finger 2 found in monocytic leukemia zinc-finger protein (MOZ) and its factor (MORF)
      cd15618
      Location:205262
      PHD1_MOZ_MORF; PHD finger 1 found in monocytic leukemia zinc-finger protein (MOZ) and its factor (MORF)
      cl27485
      Location:503777
      MOZ_SAS; MOZ/SAS family
    2. NM_001364449.1NP_001351378.1  histone acetyltransferase KAT6A

      Status: VALIDATED

      Source sequence(s)
      AC115361, AK132474
      Consensus CDS
      CCDS40294.1
      Related
      ENSMUSP00000106324.2, ENSMUST00000110696.8
      Conserved Domains (4) summary
      smart00526
      Location:85162
      H15; Domain in histone families 1 and 5
      cd15527
      Location:264310
      PHD2_KAT6A_6B; PHD finger 2 found in monocytic leukemia zinc-finger protein (MOZ) and its factor (MORF)
      cd15618
      Location:205262
      PHD1_MOZ_MORF; PHD finger 1 found in monocytic leukemia zinc-finger protein (MOZ) and its factor (MORF)
      cl27485
      Location:503777
      MOZ_SAS; MOZ/SAS family

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      23349458..23433275
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006509113.2XP_006509176.1  histone acetyltransferase KAT6A isoform X1

      Conserved Domains (4) summary
      smart00526
      Location:85162
      H15; Domain in histone families 1 and 5
      PLN00104
      Location:496770
      PLN00104; MYST -like histone acetyltransferase; Provisional
      cd15527
      Location:264310
      PHD2_KAT6A_6B; PHD finger 2 found in monocytic leukemia zinc-finger protein (MOZ) and its factor (MORF)
      cd15618
      Location:205262
      PHD1_MOZ_MORF; PHD finger 1 found in monocytic leukemia zinc-finger protein (MOZ) and its factor (MORF)
    2. XM_017312794.2XP_017168283.1  histone acetyltransferase KAT6A isoform X2

      Conserved Domains (1) summary
      PLN00104
      Location:68342
      PLN00104; MYST -like histone acetyltransferase; Provisional
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