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    Nlrp4a NLR family, pyrin domain containing 4A [ Mus musculus (house mouse) ]

    Gene ID: 243880, updated on 23-Jun-2021

    Summary

    Official Symbol
    Nlrp4aprovided by MGI
    Official Full Name
    NLR family, pyrin domain containing 4Aprovided by MGI
    Primary source
    MGI:MGI:2443697
    See related
    Ensembl:ENSMUSG00000040601
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    N; Nal; NALP4; Nalp4a; Nalp-eta; Nalp-ita; E330021B02; E330028A19Rik
    Expression
    Low expression observed in reference dataset See more
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    Genomic context

    See Nlrp4a in Genome Data Viewer
    Location:
    7; 7 A3
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (26134538..26175567)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (26435113..26476142)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 7 NC_000073.5 (27220132..27260477)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 42375 Neighboring gene cytochrome P450, family 2, subfamily a, polypeptide 4 Neighboring gene NLR family, pyrin domain containing 9C Neighboring gene NLR family, pyrin domain containing 9A Neighboring gene vomeronasal 1 receptor 185

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables molecular_function ND
    No biological Data available
    more info
     
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within defense response RCA
    inferred from Reviewed Computational Analysis
    more info
    PubMed 
    acts_upstream_of_or_within inflammatory response IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
     

    General protein information

    Preferred Names
    NACHT, LRR and PYD domains-containing protein 4A
    Names
    NACHT, leucine rich repeat and PYD containing 4A
    NACHT/LRR/pyrin domain-containing protein 4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001362156.1NP_001349085.1  NACHT, LRR and PYD domains-containing protein 4A

      Status: VALIDATED

      Source sequence(s)
      AK054378, AK087843, AK162125
      Consensus CDS
      CCDS21003.1
      Related
      ENSMUSP00000112441.2, ENSMUST00000119386.8
      Conserved Domains (5) summary
      cd08320
      Location:1091
      Pyrin_NALPs; Pyrin death domain found in NALP proteins
      sd00033
      Location:891911
      LRR_RI; leucine-rich repeat [structural motif]
      sd00034
      Location:692720
      LRR_AMN1; leucine-rich repeat [structural motif]
      pfam05729
      Location:149316
      NACHT; NACHT domain
      cl26161
      Location:692953
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    2. NM_172896.3NP_766484.1  NACHT, LRR and PYD domains-containing protein 4A

      See identical proteins and their annotated locations for NP_766484.1

      Status: VALIDATED

      Source sequence(s)
      AK087843, AK162125
      Consensus CDS
      CCDS21003.1
      UniProtKB/Swiss-Prot
      Q8BU40
      UniProtKB/TrEMBL
      B2RUQ7
      Related
      ENSMUSP00000066841.4, ENSMUST00000068767.10
      Conserved Domains (5) summary
      cd08320
      Location:1091
      Pyrin_NALPs; Pyrin death domain found in NALP proteins
      sd00033
      Location:891911
      LRR_RI; leucine-rich repeat [structural motif]
      sd00034
      Location:692720
      LRR_AMN1; leucine-rich repeat [structural motif]
      pfam05729
      Location:149316
      NACHT; NACHT domain
      cl26161
      Location:692953
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      26134538..26175567
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011250567.1XP_011248869.1  NACHT, LRR and PYD domains-containing protein 4A isoform X2

      Related
      ENSMUST00000146534.8
      Conserved Domains (4) summary
      cd08320
      Location:1091
      Pyrin_NALPs; Pyrin death domain found in NALP proteins
      pfam05729
      Location:149316
      NACHT; NACHT domain
      pfam17776
      Location:451564
      NLRC4_HD2; NLRC4 helical domain HD2
      pfam17779
      Location:393449
      NOD2_WH; NOD2 winged helix domain
    2. XM_030242565.1XP_030098425.1  NACHT, LRR and PYD domains-containing protein 4A isoform X1

      Conserved Domains (4) summary
      cd08320
      Location:1091
      Pyrin_NALPs; Pyrin death domain found in NALP proteins
      pfam05729
      Location:162329
      NACHT; NACHT domain
      pfam17776
      Location:464577
      NLRC4_HD2; NLRC4 helical domain HD2
      pfam17779
      Location:406462
      NOD2_WH; NOD2 winged helix domain
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