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    Nlrp9b NLR family, pyrin domain containing 9B [ Mus musculus (house mouse) ]

    Gene ID: 243874, updated on 23-Jun-2021

    Summary

    Official Symbol
    Nlrp9bprovided by MGI
    Official Full Name
    NLR family, pyrin domain containing 9Bprovided by MGI
    Primary source
    MGI:MGI:2675377
    See related
    Ensembl:ENSMUSG00000060508
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Na; Nalp; Nlrp9; Nalp9b; Nalp-delta
    Expression
    Biased expression in large intestine adult (RPKM 5.3), small intestine adult (RPKM 1.7) and 4 other tissues See more
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    Genomic context

    See Nlrp9b in Genome Data Viewer
    Location:
    7; 7 A3
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (19725318..19796867)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (19991393..20062942)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 7 NC_000073.5 (20593372..20648289)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene ribosomal protein L7A, pseudogene 8 Neighboring gene carcinoembryonic antigen-related cell adhesion molecule 20 Neighboring gene nuclear encoded rRNA 5S 152 Neighboring gene predicted gene 8432 Neighboring gene chromobox homolog 3 pseudogene Neighboring gene vomeronasal 1 receptor 91

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables molecular_function ND
    No biological Data available
    more info
     
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in defense response to virus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within immune system process IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within inflammatory response IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in innate immune response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of interleukin-18 production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in pyroptosis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    part_of inflammasome complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of inflammasome complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 

    General protein information

    Preferred Names
    NACHT, LRR and PYD domains-containing protein 9B
    Names
    NACHT, LRR and PYD containing protein 9b
    NLR family, pyrin domain containing 9

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_194058.2NP_918947.2  NACHT, LRR and PYD domains-containing protein 9B

      See identical proteins and their annotated locations for NP_918947.2

      Status: VALIDATED

      Source sequence(s)
      AY596196
      Consensus CDS
      CCDS20920.1
      UniProtKB/Swiss-Prot
      Q66X22
      Related
      ENSMUSP00000072895.7, ENSMUST00000073151.13
      Conserved Domains (6) summary
      cd08320
      Location:986
      Pyrin_NALPs; Pyrin death domain found in NALP proteins
      sd00033
      Location:694722
      LRR_RI; leucine-rich repeat [structural motif]
      pfam05729
      Location:144308
      NACHT; NACHT domain
      pfam17776
      Location:440555
      NLRC4_HD2; NLRC4 helical domain HD2
      pfam17779
      Location:387438
      NOD2_WH; NOD2 winged helix domain
      cl39015
      Location:752955
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      19725318..19796867
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006539938.2XP_006540001.1  NACHT, LRR and PYD domains-containing protein 9B isoform X1

      See identical proteins and their annotated locations for XP_006540001.1

      UniProtKB/Swiss-Prot
      Q66X22
      Conserved Domains (6) summary
      cd08320
      Location:986
      Pyrin_NALPs; Pyrin death domain found in NALP proteins
      sd00033
      Location:694722
      LRR_RI; leucine-rich repeat [structural motif]
      pfam05729
      Location:144308
      NACHT; NACHT domain
      pfam17776
      Location:440555
      NLRC4_HD2; NLRC4 helical domain HD2
      pfam17779
      Location:387438
      NOD2_WH; NOD2 winged helix domain
      cl39015
      Location:752955
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    2. XM_006539939.2XP_006540002.1  NACHT, LRR and PYD domains-containing protein 9B isoform X1

      See identical proteins and their annotated locations for XP_006540002.1

      UniProtKB/Swiss-Prot
      Q66X22
      Conserved Domains (6) summary
      cd08320
      Location:986
      Pyrin_NALPs; Pyrin death domain found in NALP proteins
      sd00033
      Location:694722
      LRR_RI; leucine-rich repeat [structural motif]
      pfam05729
      Location:144308
      NACHT; NACHT domain
      pfam17776
      Location:440555
      NLRC4_HD2; NLRC4 helical domain HD2
      pfam17779
      Location:387438
      NOD2_WH; NOD2 winged helix domain
      cl39015
      Location:752955
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    3. XM_011250564.1XP_011248866.1  NACHT, LRR and PYD domains-containing protein 9B isoform X3

      Conserved Domains (6) summary
      cd08320
      Location:986
      Pyrin_NALPs; Pyrin death domain found in NALP proteins
      sd00034
      Location:633667
      LRR_AMN1; leucine-rich repeat [structural motif]
      pfam05729
      Location:144308
      NACHT; NACHT domain
      pfam17776
      Location:440555
      NLRC4_HD2; NLRC4 helical domain HD2
      pfam17779
      Location:387438
      NOD2_WH; NOD2 winged helix domain
      cl39015
      Location:692899
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    4. XM_011250563.1XP_011248865.1  NACHT, LRR and PYD domains-containing protein 9B isoform X2

      Conserved Domains (6) summary
      cd08320
      Location:986
      Pyrin_NALPs; Pyrin death domain found in NALP proteins
      sd00033
      Location:639667
      LRR_RI; leucine-rich repeat [structural motif]
      pfam05729
      Location:144308
      NACHT; NACHT domain
      pfam17776
      Location:440555
      NLRC4_HD2; NLRC4 helical domain HD2
      pfam17779
      Location:387438
      NOD2_WH; NOD2 winged helix domain
      cl39015
      Location:697900
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    5. XM_011250565.1XP_011248867.1  NACHT, LRR and PYD domains-containing protein 9B isoform X4

      Conserved Domains (6) summary
      cd08320
      Location:986
      Pyrin_NALPs; Pyrin death domain found in NALP proteins
      sd00034
      Location:633667
      LRR_AMN1; leucine-rich repeat [structural motif]
      pfam05729
      Location:144308
      NACHT; NACHT domain
      pfam17776
      Location:440555
      NLRC4_HD2; NLRC4 helical domain HD2
      pfam17779
      Location:387438
      NOD2_WH; NOD2 winged helix domain
      cl39015
      Location:692839
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
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