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    Dennd11 DENN domain containing 11 [ Mus musculus (house mouse) ]

    Gene ID: 243780, updated on 2-Apr-2024


    Official Symbol
    Dennd11provided by MGI
    Official Full Name
    DENN domain containing 11provided by MGI
    Primary source
    See related
    Ensembl:ENSMUSG00000037172 AllianceGenome:MGI:2444256
    Gene type
    protein coding
    RefSeq status
    Mus musculus
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Lchn; mKIAA1147; E330009J07Rik
    Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be active in cytoplasm. Is expressed in pons ventricular layer and telencephalon mantle layer. Orthologous to human DENND11 (DENN domain containing 11). [provided by Alliance of Genome Resources, Apr 2022]
    Broad expression in cerebellum adult (RPKM 13.8), cortex adult (RPKM 7.2) and 22 other tissues See more
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    Genomic context

    6 B1; 6 18.82 cM
    Exon count:
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (40378309..40413069, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (40401375..40436135, complement)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_15673 Neighboring gene aldolase A, fructose-bisphosphate pseudogene Neighboring gene transmembrane protein 178B Neighboring gene STARR-seq mESC enhancer starr_15674 Neighboring gene STARR-seq mESC enhancer starr_15675 Neighboring gene STARR-seq mESC enhancer starr_15676 Neighboring gene STARR-seq mESC enhancer starr_15678 Neighboring gene STARR-seq mESC enhancer starr_15681 Neighboring gene STARR-seq mESC enhancer starr_15684 Neighboring gene acylglycerol kinase Neighboring gene STARR-seq mESC enhancer starr_15685 Neighboring gene WEE1 homolog 2 (S. pombe) Neighboring gene taste receptor, type 2, member 137 Neighboring gene single-stranded DNA binding protein 1

    Genomic regions, transcripts, and products


    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a



    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    General gene information


    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity IEA
    Inferred from Electronic Annotation
    more info
    enables molecular_function ND
    No biological Data available
    more info
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info

    General protein information

    Preferred Names
    DENN domain-containing protein 11
    protein LCHN

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001356375.1NP_001343304.1  DENN domain-containing protein 11

      Status: VALIDATED

      Source sequence(s)
      Consensus CDS
      Q3UHG7, Q3UT59, Q80TI8, Q8C6M2
      ENSMUSP00000099031.4, ENSMUST00000101492.10
      Conserved Domains (1) summary
      DUF2347; Uncharacterized conserved protein (DUF2347)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J


    1. NC_000072.7 Reference GRCm39 C57BL/6J

      40378309..40413069 complement
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_133929.1: Suppressed sequence

      NM_133929.1: This RefSeq record was removed by NCBI staff. Contact info@ncbi.nlm.nih.gov for further information.
    2. NM_175528.4: Suppressed sequence

      NM_175528.4: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.