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    Parp12 poly (ADP-ribose) polymerase family, member 12 [ Mus musculus (house mouse) ]

    Gene ID: 243771, updated on 26-Sep-2022

    Summary

    Official Symbol
    Parp12provided by MGI
    Official Full Name
    poly (ADP-ribose) polymerase family, member 12provided by MGI
    Primary source
    MGI:MGI:2143990
    See related
    Ensembl:ENSMUSG00000038507 AllianceGenome:MGI:2143990
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    ARTD12; PARP-12; Zc3hdc1; 9930021O16
    Summary
    Predicted to enable protein ADP-ribosylase activity. Predicted to be involved in protein auto-ADP-ribosylation and protein mono-ADP-ribosylation. Predicted to act upstream of or within protein ADP-ribosylation. Predicted to be located in nucleus. Is expressed in early conceptus; gallbladder; gut; metanephros; and reproductive system. Orthologous to human PARP12 (poly(ADP-ribose) polymerase family member 12). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in small intestine adult (RPKM 28.4), colon adult (RPKM 27.7) and 26 other tissues See more
    Orthologs
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    Genomic context

    See Parp12 in Genome Data Viewer
    Location:
    6; 6 B1
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (39063346..39095283, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (39086412..39118349, complement)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene thromboxane A synthase 1, platelet Neighboring gene RIKEN cDNA 1700025N23 gene Neighboring gene predicted gene, 46989 Neighboring gene RIKEN cDNA 4930599N23 gene Neighboring gene lysine (K)-specific demethylase 7A Neighboring gene predicted gene, 38794

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 
    • Endonuclease-mediated (1) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables NAD+ ADP-ribosyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables NAD+-protein ADP-ribosyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables NAD+-protein ADP-ribosyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables glycosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables nucleotidyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in protein auto-ADP-ribosylation ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    protein mono-ADP-ribosyltransferase PARP12
    Names
    ADP-ribosyltransferase diphtheria toxin-like 12
    poly ADP-ribose polymerase 12
    poly [ADP-ribose] polymerase 12
    zinc finger CCCH domain-containing protein 1
    zinc finger CCCH type domain containing 1
    NP_766481.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_172893.3NP_766481.2  protein mono-ADP-ribosyltransferase PARP12

      See identical proteins and their annotated locations for NP_766481.2

      Status: VALIDATED

      Source sequence(s)
      AK036886, BC048927, BC120733
      Consensus CDS
      CCDS20019.1
      UniProtKB/Swiss-Prot
      Q8BZ20, Q8R3U2
      Related
      ENSMUSP00000039704.7, ENSMUST00000038398.7
      Conserved Domains (5) summary
      smart00356
      Location:186208
      ZnF_C3H1; zinc finger
      cd01439
      Location:571687
      TCCD_inducible_PARP_like; Poly(ADP-ribose) polymerases catalyse the covalent attachment of ADP-ribose units from NAD+ to itself and to a limited number of other DNA binding proteins, which decreases their affinity for DNA. Poly(ADP-ribose) polymerase is a regulatory component ...
      pfam00644
      Location:506689
      PARP; Poly(ADP-ribose) polymerase catalytic domain
      pfam02825
      Location:387468
      WWE; WWE domain
      cl02729
      Location:309382
      WWE; WWE domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      39063346..39095283 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)