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    Kbtbd8 kelch repeat and BTB (POZ) domain containing 8 [ Mus musculus (house mouse) ]

    Gene ID: 243574, updated on 23-Jun-2021

    Summary

    Official Symbol
    Kbtbd8provided by MGI
    Official Full Name
    kelch repeat and BTB (POZ) domain containing 8provided by MGI
    Primary source
    MGI:MGI:2661430
    See related
    Ensembl:ENSMUSG00000030031
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ta; SSEC; SSEC-; Takrp; SSEC51; SSEC-51; AU040152; mKIAA1842
    Expression
    Broad expression in liver E14 (RPKM 2.0), CNS E11.5 (RPKM 1.6) and 21 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Kbtbd8 in Genome Data Viewer
    Location:
    6; 6 D2
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (95094861..95106774)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (95117880..95129793)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 6 NC_000072.5 (95067900..95079784)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 26501 Neighboring gene kelch repeat and BTB (POZ) domain containing 8, opposite strand Neighboring gene suppressor of Ty 4 homolog 1 pseudogene Neighboring gene eukaryotic translation elongation factor 1 gamma pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC91215

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    involved_in neural crest cell development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in neural crest formation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein monoubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of translation IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    part_of Cul3-RING ubiquitin ligase complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    kelch repeat and BTB domain-containing protein 8
    Names
    SSEC 51
    T-cell activation kelch repeat protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001008785.5NP_001008785.2  kelch repeat and BTB domain-containing protein 8 isoform a

      See identical proteins and their annotated locations for NP_001008785.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
      Source sequence(s)
      AK142080, BC088734, BF019958, CJ046115, DV653148
      Consensus CDS
      CCDS51856.1
      UniProtKB/Swiss-Prot
      Q3UQV5
      Related
      ENSMUSP00000032107.8, ENSMUST00000032107.10
      Conserved Domains (6) summary
      smart00612
      Location:335386
      Kelch; Kelch domain
      PHA03098
      Location:50514
      PHA03098; kelch-like protein; Provisional
      sd00038
      Location:328374
      Kelch; KELCH repeat [structural motif]
      pfam00651
      Location:39144
      BTB; BTB/POZ domain
      pfam01344
      Location:377426
      Kelch_1; Kelch motif
      pfam07707
      Location:153250
      BACK; BTB And C-terminal Kelch
    2. NM_001102670.2NP_001096140.1  kelch repeat and BTB domain-containing protein 8 isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate exon in the 5' coding region and initiates translation at a downstream start codon, compared to variant 1. It encodes isoform b, which is shorter at the N-terminus, compared to isoform a.
      Source sequence(s)
      AK142080, AK167507, BF019958, CJ046115
      Consensus CDS
      CCDS51857.1
      UniProtKB/Swiss-Prot
      Q3UQV5
      Related
      ENSMUSP00000113739.2, ENSMUST00000119582.3
      Conserved Domains (5) summary
      smart00612
      Location:258309
      Kelch; Kelch domain
      sd00038
      Location:251297
      Kelch; KELCH repeat [structural motif]
      pfam00651
      Location:167
      BTB; BTB/POZ domain
      pfam01344
      Location:300349
      Kelch_1; Kelch motif
      pfam07707
      Location:76173
      BACK; BTB And C-terminal Kelch

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      95094861..95106774
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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