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    Pramel12 PRAME like 12 [ Mus musculus (house mouse) ]

    Gene ID: 242736, updated on 8-Jul-2021

    Summary

    Official Symbol
    Pramel12provided by MGI
    Official Full Name
    PRAME like 12provided by MGI
    Primary source
    MGI:MGI:2140473
    See related
    Ensembl:ENSMUSG00000046862
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Pram; Pramef8; AU023234; 4732496O08Rik
    Expression
    Ubiquitous expression in testis adult (RPKM 3.7), limb E14.5 (RPKM 3.2) and 28 other tissues See more
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    Genomic context

    See Pramel12 in Genome Data Viewer
    Location:
    4; 4 E1
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (143137457..143147661)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (143412155..143421091)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 4 NC_000070.5 (143002329..143010990)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene Bacidic (leucine-rich) nuclear phosphoprotein 32 family, member B, pseudogene 1 Neighboring gene PRAME like 1 Neighboring gene oogenesin 4 Neighboring gene KH-type splicing regulatory protein pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ubiquitin ligase-substrate adaptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
     
    Component Evidence Code Pubs
    part_of Cul2-RING ubiquitin ligase complex ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001355724.1NP_001342653.1  PRAME family member 8

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AK029142, BC056931, BQ745938
      Consensus CDS
      CCDS38944.1
      Related
      ENSMUSP00000041323.8, ENSMUST00000037356.8
      Conserved Domains (2) summary
      sd00033
      Location:251271
      LRR_RI; leucine-rich repeat [structural motif]
      cl12013
      Location:238338
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
    2. NM_172877.3NP_766465.1  PRAME family member 8

      See identical proteins and their annotated locations for NP_766465.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AK029142, BC056931
      Consensus CDS
      CCDS38944.1
      UniProtKB/TrEMBL
      Q8CE24
      Related
      ENSMUSP00000058676.4, ENSMUST00000059790.11
      Conserved Domains (2) summary
      sd00033
      Location:251271
      LRR_RI; leucine-rich repeat [structural motif]
      cl12013
      Location:238338
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      143137457..143147661
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006538857.5XP_006538920.1  PRAME family member 8 isoform X1

      See identical proteins and their annotated locations for XP_006538920.1

      UniProtKB/TrEMBL
      Q8CE24
      Conserved Domains (2) summary
      sd00033
      Location:251271
      LRR_RI; leucine-rich repeat [structural motif]
      cl12013
      Location:238338
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
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