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    Chrm3 cholinergic receptor, muscarinic 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 24260, updated on 27-Nov-2024

    Summary

    Official Symbol
    Chrm3provided by RGD
    Official Full Name
    cholinergic receptor, muscarinic 3provided by RGD
    Primary source
    RGD:2343
    See related
    EnsemblRapid:ENSRNOG00000049410 AllianceGenome:RGD:2343
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables several functions, including G protein-coupled acetylcholine receptor activity; G protein-coupled acetylcholine receptor binding activity; and acetylcholine binding activity. Involved in G protein-coupled acetylcholine receptor signaling pathway; negative regulation of heart rate by acetylcholine; and positive regulation of vascular associated smooth muscle contraction. Located in several cellular components, including asymmetric synapse; axon terminus; and dendrite. Is active in glutamatergic synapse; postsynaptic density membrane; and presynaptic membrane. Human ortholog(s) of this gene implicated in bladder disease; chronic obstructive pulmonary disease; prune belly syndrome; and pulmonary fibrosis. Orthologous to human CHRM3 (cholinergic receptor muscarinic 3). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Brain (RPKM 55.0), Kidney (RPKM 22.4) and 5 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Chrm3 in Genome Data Viewer
    Location:
    17q12.1
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 17 NC_086035.1 (64696549..65158622)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 17 NC_051352.1 (60005137..60467250)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (63990599..64463222, complement)

    Chromosome 17 - NC_086035.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120097813 Neighboring gene NSA2 ribosome biogenesis factor, pseudogene 11 Neighboring gene uncharacterized LOC134482864 Neighboring gene uncharacterized LOC134482865 Neighboring gene zinc finger, MYND-type containing 11

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in G protein-coupled acetylcholine receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in G protein-coupled acetylcholine receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in acetylcholine receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within calcium-mediated signaling ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in chemical synaptic transmission IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in ion channel modulating, G protein-coupled receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in ligand-gated ion channel signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of heart rate by acetylcholine IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in phospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of insulin secretion ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of smooth muscle contraction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of vascular associated smooth muscle contraction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of vasoconstriction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within regulation of monoatomic ion transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of smooth muscle contraction IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in response to acetylcholine IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within saliva secretion ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of smooth muscle contraction ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within smooth muscle contraction ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within synaptic transmission, cholinergic ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in asymmetric synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in axon terminus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in basal plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in basolateral plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in dendrite IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in dendrite IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in postsynaptic density membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in presynaptic membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in synapse IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    muscarinic acetylcholine receptor M3
    Names
    cholinergic receptor, muscarinic 3, cardiac

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_012527.2NP_036659.2  muscarinic acetylcholine receptor M3

      See identical proteins and their annotated locations for NP_036659.2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000017
      UniProtKB/Swiss-Prot
      P08483, Q9QWK9
      UniProtKB/TrEMBL
      A6KN24
      Related
      ENSRNOP00000080306.1, ENSRNOT00000118676.2
      Conserved Domains (3) summary
      cd15299
      Location:65269
      7tmA_mAChR_M3; muscarinic acetylcholine receptor subtype M3, member of the class A family of seven-transmembrane G protein-coupled receptors
      cd14964
      Location:486513
      7tm_GPCRs; TM helix 6 [structural motif]
      cl28897
      Location:483563
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086035.1 Reference GRCr8

      Range
      64696549..65158622
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063276047.1XP_063132117.1  muscarinic acetylcholine receptor M3 isoform X1

      UniProtKB/Swiss-Prot
      P08483, Q9QWK9
      UniProtKB/TrEMBL
      A6KN24
    2. XM_063276048.1XP_063132118.1  muscarinic acetylcholine receptor M3 isoform X1

      UniProtKB/Swiss-Prot
      P08483, Q9QWK9
      UniProtKB/TrEMBL
      A6KN24
    3. XM_039095336.2XP_038951264.1  muscarinic acetylcholine receptor M3 isoform X1

      UniProtKB/Swiss-Prot
      P08483, Q9QWK9
      UniProtKB/TrEMBL
      A6KN24
      Related
      ENSRNOP00000086603.1, ENSRNOT00000107962.2
      Conserved Domains (3) summary
      cd15299
      Location:65269
      7tmA_mAChR_M3; muscarinic acetylcholine receptor subtype M3, member of the class A family of seven-transmembrane G protein-coupled receptors
      cd14964
      Location:486513
      7tm_GPCRs; TM helix 6 [structural motif]
      cl28897
      Location:483563
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
    4. XM_063276043.1XP_063132113.1  muscarinic acetylcholine receptor M3 isoform X1

      UniProtKB/Swiss-Prot
      P08483, Q9QWK9
      UniProtKB/TrEMBL
      A6KN24
      Related
      ENSRNOP00000110565.1, ENSRNOT00000160680.1
    5. XM_063276044.1XP_063132114.1  muscarinic acetylcholine receptor M3 isoform X1

      UniProtKB/Swiss-Prot
      P08483, Q9QWK9
      UniProtKB/TrEMBL
      A6KN24
      Related
      ENSRNOP00000090433.1, ENSRNOT00000103154.2
    6. XM_017600449.3XP_017455938.1  muscarinic acetylcholine receptor M3 isoform X1

      UniProtKB/Swiss-Prot
      P08483, Q9QWK9
      UniProtKB/TrEMBL
      A6KN24
      Related
      ENSRNOP00000090085.1, ENSRNOT00000102670.2
      Conserved Domains (3) summary
      cd15299
      Location:65269
      7tmA_mAChR_M3; muscarinic acetylcholine receptor subtype M3, member of the class A family of seven-transmembrane G protein-coupled receptors
      cd14964
      Location:486513
      7tm_GPCRs; TM helix 6 [structural motif]
      cl28897
      Location:483563
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
    7. XM_063276046.1XP_063132116.1  muscarinic acetylcholine receptor M3 isoform X1

      UniProtKB/Swiss-Prot
      P08483, Q9QWK9
      UniProtKB/TrEMBL
      A6KN24
    8. XM_063276045.1XP_063132115.1  muscarinic acetylcholine receptor M3 isoform X1

      UniProtKB/Swiss-Prot
      P08483, Q9QWK9
      UniProtKB/TrEMBL
      A6KN24
      Related
      ENSRNOP00000087869.1, ENSRNOT00000113544.2
    9. XM_039095337.2XP_038951265.1  muscarinic acetylcholine receptor M3 isoform X1

      UniProtKB/Swiss-Prot
      P08483, Q9QWK9
      UniProtKB/TrEMBL
      A6KN24
      Conserved Domains (3) summary
      cd15299
      Location:65269
      7tmA_mAChR_M3; muscarinic acetylcholine receptor subtype M3, member of the class A family of seven-transmembrane G protein-coupled receptors
      cd14964
      Location:486513
      7tm_GPCRs; TM helix 6 [structural motif]
      cl28897
      Location:483563
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
    10. XM_039095338.2XP_038951266.1  muscarinic acetylcholine receptor M3 isoform X1

      UniProtKB/Swiss-Prot
      P08483, Q9QWK9
      UniProtKB/TrEMBL
      A6KN24
      Conserved Domains (3) summary
      cd15299
      Location:65269
      7tmA_mAChR_M3; muscarinic acetylcholine receptor subtype M3, member of the class A family of seven-transmembrane G protein-coupled receptors
      cd14964
      Location:486513
      7tm_GPCRs; TM helix 6 [structural motif]
      cl28897
      Location:483563
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily