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    Akt1 AKT serine/threonine kinase 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 24185, updated on 10-Jul-2024

    Summary

    Official Symbol
    Akt1provided by RGD
    Official Full Name
    AKT serine/threonine kinase 1provided by RGD
    Primary source
    RGD:2081
    See related
    EnsemblRapid:ENSRNOG00000028629 AllianceGenome:RGD:2081
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Akt
    Summary
    Enables several functions, including ATP binding activity; GTPase activating protein binding activity; and enzyme binding activity. Involved in several processes, including cellular macromolecule biosynthetic process; cellular response to mechanical stimulus; and regulation of cellular protein metabolic process. Acts upstream of or within several processes, including cellular response to insulin stimulus; negative regulation of cell size; and positive regulation of sodium ion transport. Located in cytosol; mitochondrion; and nucleus. Used to study autosomal recessive polycystic kidney disease; hypertension; impotence; myocardial infarction; and type 2 diabetes mellitus. Biomarker of several diseases, including brain ischemia; colon cancer; diabetic retinopathy; type 2 diabetes mellitus; and ureteral obstruction. Human ortholog(s) of this gene implicated in several diseases, including Cowden syndrome 6; breast cancer (multiple); lung disease (multiple); pancreatic cancer (multiple); and reproductive organ cancer (multiple). Orthologous to human AKT1 (AKT serine/threonine kinase 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Heart (RPKM 317.3), Adrenal (RPKM 243.5) and 9 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Akt1 in Genome Data Viewer
    Location:
    6q32
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (137534810..137555131, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (131713716..131735319, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (137218398..137239970, complement)

    Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene adenylosuccinate synthase 1 Neighboring gene SIVA1, apoptosis-inducing factor Neighboring gene zinc finger and BTB domain containing 42 Neighboring gene uncharacterized LOC134479262

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables 14-3-3 protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables 14-3-3 protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables ATP binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATP binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables GTPase activating protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables calmodulin binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables calmodulin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables calmodulin binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables enzyme binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables nitric-oxide synthase regulator activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables nitric-oxide synthase regulator activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables phosphatidylinositol-3,4,5-trisphosphate binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables phosphatidylinositol-3,4,5-trisphosphate binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables phosphatidylinositol-3,4-bisphosphate binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables phosphatidylinositol-3,4-bisphosphate binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables potassium channel activator activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables potassium channel activator activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables potassium channel activator activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein homodimerization activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein kinase C binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein kinase binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein kinase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein phosphatase 2A binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein serine kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein serine/threonine kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables protein serine/threonine kinase activity TAS
    Traceable Author Statement
    more info
    PubMed 
    enables protein serine/threonine kinase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein serine/threonine kinase inhibitor activity IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein serine/threonine/tyrosine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein serine/threonine/tyrosine kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in DNA damage response IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in activation-induced cell death of T cells IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within activation-induced cell death of T cells ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in apoptotic mitochondrial changes IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within apoptotic mitochondrial changes ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in behavioral response to pain IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in behavioral response to pain ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in canonical NF-kappaB signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in canonical NF-kappaB signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cell migration involved in sprouting angiogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cell migration involved in sprouting angiogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within cell projection organization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cellular response to cadmium ion IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to cadmium ion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to decreased oxygen levels IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within cellular response to decreased oxygen levels ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to epidermal growth factor stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to epidermal growth factor stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to epidermal growth factor stimulus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in cellular response to granulocyte macrophage colony-stimulating factor stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within cellular response to granulocyte macrophage colony-stimulating factor stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within cellular response to growth factor stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to hypoxia IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within cellular response to insulin stimulus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cellular response to insulin stimulus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within cellular response to insulin stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to insulin stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to insulin stimulus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in cellular response to mechanical stimulus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cellular response to nerve growth factor stimulus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cellular response to nerve growth factor stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to nerve growth factor stimulus IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in cellular response to nerve growth factor stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to organic cyclic compound IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cellular response to oxidised low-density lipoprotein particle stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to oxidised low-density lipoprotein particle stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to peptide IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within cellular response to peptide ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to prostaglandin E stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within cellular response to prostaglandin E stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to reactive oxygen species IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to reactive oxygen species ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to tumor necrosis factor IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within cellular response to tumor necrosis factor ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to vascular endothelial growth factor stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within cellular response to vascular endothelial growth factor stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in epidermal growth factor receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in epidermal growth factor receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in establishment of protein localization to mitochondrion IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in establishment of protein localization to mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in execution phase of apoptosis IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within execution phase of apoptosis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in gene expression IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within_positive_effect gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within germ cell development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in glucose homeostasis IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within glucose homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in glucose metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within glucose metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in glycogen biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in glycogen biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in glycogen cell differentiation involved in embryonic placenta development IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within glycogen cell differentiation involved in embryonic placenta development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in glycogen metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within glycogen metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in inflammatory response IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within inflammatory response ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in inflammatory response ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in insulin receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in insulin receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in insulin receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in insulin receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in insulin receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in insulin-like growth factor receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in insulin-like growth factor receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in insulin-like growth factor receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in interleukin-18-mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in interleukin-18-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within intracellular signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in labyrinthine layer blood vessel development IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within labyrinthine layer blood vessel development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in lipopolysaccharide-mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within lipopolysaccharide-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in maintenance of protein location in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in maintenance of protein location in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in mammalian oogenesis stage IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within mammalian oogenesis stage ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in maternal placenta development IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within maternal placenta development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of JNK cascade IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of apoptotic process TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in negative regulation of autophagy IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of autophagy ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of cGAS/STING signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of cGAS/STING signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of calcium import into the mitochondrion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of cell size IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of cilium assembly IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of cilium assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of cilium assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of fatty acid beta-oxidation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of fatty acid beta-oxidation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of gene expression IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of intrinsic apoptotic signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of intrinsic apoptotic signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of leukocyte cell-cell adhesion IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of leukocyte cell-cell adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of long-chain fatty acid import across plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of long-chain fatty acid import across plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of lymphocyte migration IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of lymphocyte migration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of protein localization to lysosome IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of protein localization to lysosome ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of protein localization to lysosome ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of protein ubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of proteolysis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of proteolysis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of release of cytochrome c from mitochondria IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of release of cytochrome c from mitochondria ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of release of cytochrome c from mitochondria ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of superoxide anion generation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in non-canonical NF-kappaB signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in non-canonical NF-kappaB signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in osteoblast differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within osteoblast differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in peptidyl-serine phosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in peripheral nervous system myelin maintenance IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within peripheral nervous system myelin maintenance ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in phosphatidylinositol 3-kinase/protein kinase B signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within phosphatidylinositol 3-kinase/protein kinase B signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in phosphatidylinositol 3-kinase/protein kinase B signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of G1/S transition of mitotic cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of G1/S transition of mitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of I-kappaB phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of I-kappaB phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of TORC1 signaling IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of TORC1 signaling ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of TORC1 signaling ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of blood vessel endothelial cell migration IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of blood vessel endothelial cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cell growth IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of cell growth IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of cell growth ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of endothelial cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of endothelial cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of endothelial cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of endothelial cell proliferation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of fat cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of fat cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of fibroblast migration IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within positive regulation of fibroblast migration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of gene expression IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of glucose import IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of glucose import ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of glucose metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of glycogen biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of glycogen biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of lipid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of lipid biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of lipid biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of mitochondrial membrane potential IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of nitric oxide biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of nitric oxide biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of organ growth IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within positive regulation of organ growth ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of peptidyl-serine phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of peptidyl-serine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within positive regulation of proteasomal ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of protein localization to cell surface IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of protein localization to cell surface ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of protein localization to endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of protein localization to endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of protein localization to nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of protein localization to nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of protein localization to plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of protein localization to plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of protein metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of smooth muscle cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of smooth muscle cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of sodium ion transport IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within positive regulation of sodium ion transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of sodium ion transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of vasoconstriction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of proteasome-mediated ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein import into nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein import into nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within protein ubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of aerobic respiration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of apoptotic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of cell migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of glycogen biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of myelination IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within regulation of myelination ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of neuron projection development IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within regulation of neuron projection development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of neuron projection development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of neuron projection development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of postsynapse organization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of postsynapse organization ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of protein localization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within regulation of protein localization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of protein localization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of tRNA methylation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of tRNA methylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of translation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to UV-A IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to UV-A ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to fluid shear stress IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to fluid shear stress ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to food IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within response to food ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to growth factor ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to growth hormone ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in response to heat IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to heat ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to hormone ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to insulin-like growth factor stimulus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in response to ischemia IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to oxidative stress ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in sphingosine-1-phosphate receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in sphingosine-1-phosphate receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in spinal cord development IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in striated muscle cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within striated muscle cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in translation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cell-cell junction IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cell-cell junction ISO
    Inferred from Sequence Orthology
    more info
     
    located_in ciliary basal body IEA
    Inferred from Electronic Annotation
    more info
     
    located_in ciliary basal body ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in glutamatergic synapse IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in microtubule cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in mitochondrial intermembrane space ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
     
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    part_of protein-containing complex IEA
    Inferred from Electronic Annotation
    more info
     
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in spindle IEA
    Inferred from Electronic Annotation
    more info
     
    located_in spindle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in vesicle IEA
    Inferred from Electronic Annotation
    more info
     
    located_in vesicle ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    RAC-alpha serine/threonine-protein kinase
    Names
    AKT1 kinase
    PKB alpha
    RAC protein kinase alpha RAC-PK alpha
    RAC-PK-alpha
    murine thymoma viral (v-akt) oncogene homolog 1
    protein kinase B alpha
    thymoma viral proto-oncogene 1
    v-akt murine thymoma viral oncogene homolog 1
    NP_150233.1
    XP_038967701.1
    XP_063117611.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_033230.3NP_150233.1  RAC-alpha serine/threonine-protein kinase

      See identical proteins and their annotated locations for NP_150233.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000006
      UniProtKB/Swiss-Prot
      P47196
      UniProtKB/TrEMBL
      A0A8L2QJ86, A6KBV9
      Related
      ENSRNOP00000090205.2, ENSRNOT00000114705.2
      Conserved Domains (2) summary
      cd01241
      Location:4111
      PH_PKB; Protein Kinase B-like pleckstrin homology (PH) domain
      cd05594
      Location:124479
      STKc_PKB_alpha; Catalytic domain of the Serine/Threonine Kinase, Protein Kinase B alpha (also called Akt1)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086024.1 Reference GRCr8

      Range
      137534810..137555131 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039111773.2XP_038967701.1  RAC-alpha serine/threonine-protein kinase isoform X1

      UniProtKB/Swiss-Prot
      P47196
      UniProtKB/TrEMBL
      A0A8L2QJ86, A6KBV9
      Conserved Domains (2) summary
      cd01241
      Location:4111
      PH_PKB; Protein Kinase B-like pleckstrin homology (PH) domain
      cd05594
      Location:124479
      STKc_PKB_alpha; Catalytic domain of the Serine/Threonine Kinase, Protein Kinase B alpha (also called Akt1)
    2. XM_063261541.1XP_063117611.1  RAC-alpha serine/threonine-protein kinase isoform X1

      UniProtKB/Swiss-Prot
      P47196
      UniProtKB/TrEMBL
      A0A8L2QJ86, A6KBV9