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    Wdr76 WD repeat domain 76 [ Mus musculus (house mouse) ]

    Gene ID: 241627, updated on 23-Jun-2021

    Summary

    Official Symbol
    Wdr76provided by MGI
    Official Full Name
    WD repeat domain 76provided by MGI
    Primary source
    MGI:MGI:1926186
    See related
    Ensembl:ENSMUSG00000027242
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    AA517836; 6030457D09; 5830411K18Rik
    Expression
    Broad expression in liver E14 (RPKM 5.6), CNS E11.5 (RPKM 5.5) and 23 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Wdr76 in Genome Data Viewer
    Location:
    2; 2 E5
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (121337204..121375341)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (121506723..121544860)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 2 NC_000068.6 (121332459..121370596)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene WD repeat domain 76 pseudogene Neighboring gene mitochondrial ribosomal protein L51 pseudogene Neighboring gene microfibrillar-associated protein 1A Neighboring gene FERM domain containing 5 Neighboring gene septin 2 pseudogene Neighboring gene ribosomal protein S4, X-linked pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables enzyme binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in cellular response to DNA damage stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of DNA damage checkpoint IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in heterochromatin ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in site of DNA damage ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    WD repeat-containing protein 76

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001290986.1NP_001277915.1  WD repeat-containing protein 76 isoform a

      See identical proteins and their annotated locations for NP_001277915.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Both variants 1 and 2 encode the same isoform (a).
      Source sequence(s)
      AK031592, BC094676, BY720216
      Consensus CDS
      CCDS38218.1
      UniProtKB/Swiss-Prot
      A6PWY4
      Related
      ENSMUSP00000106232.3, ENSMUST00000110602.9
      Conserved Domains (3) summary
      COG2319
      Location:214484
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:218258
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:214423
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    2. NM_001290987.1NP_001277916.1  WD repeat-containing protein 76 isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an alternate exon, and it thus differs in its 5' UTR and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (b) is shorter at the N-terminus, compared to isoform a.
      Source sequence(s)
      AK031592, BC094676, BY720216
      UniProtKB/Swiss-Prot
      A6PWY4
      Conserved Domains (3) summary
      COG2319
      Location:60330
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:64104
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:60269
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    3. NM_001369185.1NP_001356114.1  WD repeat-containing protein 76 isoform c

      Status: VALIDATED

      Description
      Transcript Variant: This isoform encodes the longest isoform (c).
      Source sequence(s)
      AL928678
      Consensus CDS
      CCDS89546.1
      Related
      ENSMUSP00000106234.2, ENSMUST00000110603.2
      Conserved Domains (2) summary
      sd00039
      Location:316356
      7WD40; WD40 repeat [structural motif]
      cl29593
      Location:312521
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    4. NM_030234.2NP_084510.2  WD repeat-containing protein 76 isoform a

      See identical proteins and their annotated locations for NP_084510.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes isoform 1.
      Source sequence(s)
      AK031592, AK162181, BC094676, BY019145
      Consensus CDS
      CCDS38218.1
      UniProtKB/Swiss-Prot
      A6PWY4
      Related
      ENSMUSP00000028676.6, ENSMUST00000028676.12
      Conserved Domains (3) summary
      COG2319
      Location:214484
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:218258
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:214423
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      121337204..121375341
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011239529.3XP_011237831.1  WD repeat-containing protein 76 isoform X1

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