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    Acly ATP citrate lyase [ Rattus norvegicus (Norway rat) ]

    Gene ID: 24159, updated on 10-Jul-2024

    Summary

    Official Symbol
    Aclyprovided by RGD
    Official Full Name
    ATP citrate lyaseprovided by RGD
    Primary source
    RGD:2018
    See related
    EnsemblRapid:ENSRNOG00000016924 AllianceGenome:RGD:2018
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    ACL; Clatp
    Summary
    Enables ATP citrate synthase activity. Involved in acetyl-CoA metabolic process; citrate metabolic process; and fatty acid biosynthetic process. Predicted to be located in nucleoplasm and plasma membrane. Predicted to be active in cytosol. Orthologous to human ACLY (ATP citrate lyase). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Adrenal (RPKM 1293.6), Liver (RPKM 1056.3) and 9 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Acly in Genome Data Viewer
    Location:
    10q31
    Exon count:
    30
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (85912402..85964605, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (85412045..85464253, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (88392248..88442845, complement)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene kelch-like family member 10 Neighboring gene kelch-like family member 11 Neighboring gene transfer RNA serine (anticodon AGA) 28 Neighboring gene outer dynein arm docking complex subunit 4

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC124629

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATP citrate synthase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables ATP citrate synthase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables ATP citrate synthase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATP citrate synthase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables acyltransferase activity, acyl groups converted into alkyl on transfer IEA
    Inferred from Electronic Annotation
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in acetyl-CoA biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in acetyl-CoA biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in acetyl-CoA biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in acetyl-CoA biosynthetic process NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in acetyl-CoA metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in citrate metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in citrate metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in citrate metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in fatty acid biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in fatty acid biosynthetic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in fatty acid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in fatty acid biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in lipid biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in lipid biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in oxaloacetate metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in oxaloacetate metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    ATP-citrate synthase
    Names
    ATP-citrate (pro-S-)-lyase
    citrate cleavage enzyme
    NP_001104565.1
    NP_058683.2
    XP_038941092.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001111095.1NP_001104565.1  ATP-citrate synthase isoform 2

      See identical proteins and their annotated locations for NP_001104565.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate exon in the coding region compared to variant 1. The resulting protein (isoform 2) is shorter but has the same N- and C-termini compared to isoform 1.
      Source sequence(s)
      BC100618, CB800173, CR471829, DY473160, J05210
      UniProtKB/Swiss-Prot
      P16638, Q497C7, Q8VIQ1
      UniProtKB/TrEMBL
      A6HJ38, G3V9G4
      Related
      ENSRNOP00000046597.3, ENSRNOT00000043172.6
      Conserved Domains (6) summary
      cd06100
      Location:8461083
      CCL_ACL-C; Citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CCL cleaves citryl-CoA (CiCoA) to acetyl-CoA (AcCoA) and oxaloacetate (OAA). ...
      PLN02235
      Location:1419
      PLN02235; ATP citrate (pro-S)-lyase
      PLN02522
      Location:4791084
      PLN02522; ATP citrate (pro-S)-lyase
      pfam16114
      Location:247421
      Citrate_bind; ATP citrate lyase citrate-binding
      cl21454
      Location:487590
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
      cl22543
      Location:650775
      Ligase_CoA; CoA-ligase
    2. NM_016987.2NP_058683.2  ATP-citrate synthase isoform 1

      See identical proteins and their annotated locations for NP_058683.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer protein (isoform 1).
      Source sequence(s)
      BC100618, CB800173, CR471829, DY473160, J05210
      UniProtKB/Swiss-Prot
      P16638, Q497C7, Q8VIQ1
      UniProtKB/TrEMBL
      A6HJ39, G3V888
      Related
      ENSRNOP00000023447.3, ENSRNOT00000023447.8
      Conserved Domains (2) summary
      PLN02522
      Location:4891094
      PLN02522; ATP citrate (pro-S)-lyase
      cl29684
      Location:1419
      Citrate_bind; ATP citrate lyase citrate-binding

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      85912402..85964605 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039085164.2XP_038941092.1  ATP-citrate synthase isoform X1

      UniProtKB/Swiss-Prot
      P16638, Q497C7, Q8VIQ1
      UniProtKB/TrEMBL
      A6HJ39, G3V888
      Conserved Domains (2) summary
      PLN02522
      Location:4891094
      PLN02522; ATP citrate (pro-S)-lyase
      cl29684
      Location:1419
      Citrate_bind; ATP citrate lyase citrate-binding