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    Cers6 ceramide synthase 6 [ Mus musculus (house mouse) ]

    Gene ID: 241447, updated on 23-Jun-2021

    Summary

    Official Symbol
    Cers6provided by MGI
    Official Full Name
    ceramide synthase 6provided by MGI
    Primary source
    MGI:MGI:2442564
    See related
    Ensembl:ENSMUSG00000027035
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    L; T1; Cer; T1L; Lass6; AW544719; 4732462C07Rik
    Expression
    Ubiquitous expression in CNS E18 (RPKM 3.5), large intestine adult (RPKM 3.5) and 27 other tissues See more
    Orthologs
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    Genomic context

    See Cers6 in Genome Data Viewer
    Location:
    2; 2 C2
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (68691489..68944628)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (68861145..69114284)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 2 NC_000068.6 (68699614..68949347)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene predicted gene, 36231 Neighboring gene predicted gene, 36174 Neighboring gene predicted gene 13612 Neighboring gene predicted gene, 52515 Neighboring gene predicted gene, 39840 Neighboring gene nitric oxide synthase trafficker Neighboring gene SPC25, NDC80 kinetochore complex component, homolog (S. cerevisiae)

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables N-acyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables sphingosine N-acyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables sphingosine N-acyltransferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables sphingosine N-acyltransferase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables sphingosine N-acyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    ceramide synthase 6
    Names
    LAG1 homolog, ceramide synthase 6
    LAG1 longevity assurance homolog 6
    longevity assurance homolog 6

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001347161.1NP_001334090.1  ceramide synthase 6 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer protein (isoform 1).
      Source sequence(s)
      AL929137, AL929221
      Consensus CDS
      CCDS84532.1
      UniProtKB/TrEMBL
      H3BL08
      Related
      ENSMUSP00000135604.2, ENSMUST00000176018.2
      Conserved Domains (2) summary
      cd00086
      Location:76127
      homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
      pfam03798
      Location:131324
      TRAM_LAG1_CLN8; TLC domain
    2. NM_172856.4NP_766444.1  ceramide synthase 6 isoform 2

      See identical proteins and their annotated locations for NP_766444.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an in-frame exon in the 3' coding region compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
      Source sequence(s)
      AK028849, AL929137, AL929221
      Consensus CDS
      CCDS16086.1
      UniProtKB/Swiss-Prot
      Q8C172
      Related
      ENSMUSP00000028426.3, ENSMUST00000028426.9
      Conserved Domains (2) summary
      cd00086
      Location:76127
      homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
      pfam03798
      Location:131324
      TRAM_LAG1_CLN8; TLC domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      68691489..68944628
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017318074.1XP_017173563.1  ceramide synthase 6 isoform X1

      Conserved Domains (1) summary
      pfam03798
      Location:6193
      TRAM_LAG1_CLN8; TLC domain

    RNA

    1. XR_374464.4 RNA Sequence

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