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    Cers6 ceramide synthase 6 [ Mus musculus (house mouse) ]

    Gene ID: 241447, updated on 14-Oct-2018

    Summary

    Official Symbol
    Cers6provided by MGI
    Official Full Name
    ceramide synthase 6provided by MGI
    Primary source
    MGI:MGI:2442564
    See related
    Ensembl:ENSMUSG00000027035 Vega:OTTMUSG00000012972
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    T1L; Lass6; AW544719; 4732462C07Rik
    Expression
    Ubiquitous expression in CNS E18 (RPKM 3.5), large intestine adult (RPKM 3.5) and 27 other tissues See more
    Orthologs

    Genomic context

    See Cers6 in Genome Data Viewer
    Location:
    2; 2 C2
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 2 NC_000068.7 (68861136..69114284)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 2 NC_000068.6 (68699614..68949347)

    Chromosome 2 - NC_000068.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 36231 Neighboring gene predicted gene, 36174 Neighboring gene predicted gene 13612 Neighboring gene predicted gene, 39840 Neighboring gene nitric oxide synthase trafficker

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    sphingosine N-acyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    sphingosine N-acyltransferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    ceramide biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    ceramide biosynthetic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    sphingolipid biosynthetic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    PubMed 
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    nucleus IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    ceramide synthase 6
    Names
    LAG1 homolog, ceramide synthase 6
    LAG1 longevity assurance homolog 6
    longevity assurance homolog 6

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001347161.1NP_001334090.1  ceramide synthase 6 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer protein (isoform 1).
      Source sequence(s)
      AL929137, AL929221
      Consensus CDS
      CCDS84532.1
      UniProtKB/TrEMBL
      H3BL08
    2. NM_172856.4NP_766444.1  ceramide synthase 6 isoform 2

      See identical proteins and their annotated locations for NP_766444.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an in-frame exon in the 3' coding region compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
      Source sequence(s)
      AK028849, AL929137, AL929221
      Consensus CDS
      CCDS16086.1
      UniProtKB/Swiss-Prot
      Q8C172
      Related
      ENSMUSP00000028426.2, OTTMUSP00000013978, ENSMUST00000028426.8, OTTMUST00000031236
      Conserved Domains (2) summary
      cd00086
      Location:76127
      homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
      pfam03798
      Location:131324
      TRAM_LAG1_CLN8; TLC domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000068.7 Reference GRCm38.p4 C57BL/6J

      Range
      68861136..69114284
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006499452.3XP_006499515.1  ceramide synthase 6 isoform X1

      Related
      ENSMUSP00000135604.1, OTTMUSP00000061311, ENSMUST00000176018.1, OTTMUST00000110037
      Conserved Domains (2) summary
      cd00086
      Location:76127
      homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
      pfam03798
      Location:131324
      TRAM_LAG1_CLN8; TLC domain
    2. XM_017318074.1XP_017173563.1  ceramide synthase 6 isoform X2

    RNA

    1. XR_374464.3 RNA Sequence

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