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    Lrrc8a leucine rich repeat containing 8A VRAC subunit A [ Mus musculus (house mouse) ]

    Gene ID: 241296, updated on 26-Oct-2021

    Summary

    Official Symbol
    Lrrc8aprovided by MGI
    Official Full Name
    leucine rich repeat containing 8A VRAC subunit Aprovided by MGI
    Primary source
    MGI:MGI:2652847
    See related
    Ensembl:ENSMUSG00000007476
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    ebo; Lrrc8; SWELL1; mKIAA1437
    Expression
    Ubiquitous expression in lung adult (RPKM 34.6), ovary adult (RPKM 30.0) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Lrrc8a in Genome Data Viewer
    Location:
    2; 2 B
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (30127781..30153802)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (30237769..30263790)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 2 NC_000068.6 (30093289..30119310)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene kynurenine aminotransferase 1 Neighboring gene predicted gene, 31201 Neighboring gene RIKEN cDNA 1700084E18 gene Neighboring gene phytanoyl-CoA dioxygenase domain containing 1 Neighboring gene dolichol kinase

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Potential readthrough

    Included gene: Phyhd1

    Homology

    Clone Names

    • MGC61242

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    contributes_to anion channel activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables cyclic-GMP-AMP transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables volume-sensitive anion channel activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in anion transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in anion transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in aspartate transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cell volume homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in chloride transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cyclic-GMP-AMP transmembrane import across plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within ion transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein hexamerization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to osmotic stress ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within spermatogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in taurine transport ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in cell surface ISO
    Inferred from Sequence Orthology
    more info
     
    located_in integral component of lysosomal membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in integral component of membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in integral component of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    part_of ion channel complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in lysosome IEA
    Inferred from Electronic Annotation
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    volume-regulated anion channel subunit LRRC8A
    Names
    leucine-rich repeat-containing 8
    leucine-rich repeat-containing protein 8A
    protein ebouriffe

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_177725.4NP_808393.1  volume-regulated anion channel subunit LRRC8A

      See identical proteins and their annotated locations for NP_808393.1

      Status: VALIDATED

      Source sequence(s)
      AL845258, BQ444045
      Consensus CDS
      CCDS15875.1
      UniProtKB/Swiss-Prot
      Q80WG5
      Related
      ENSMUSP00000092690.3, ENSMUST00000095078.3
      Conserved Domains (3) summary
      COG4886
      Location:514789
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      sd00033
      Location:546568
      LRR_RI; leucine-rich repeat [structural motif]
      pfam12534
      Location:1340
      Pannexin_like; Pannexin-like TM region of LRRC8

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      30127781..30153802
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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