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    Rbck1 RanBP-type and C3HC4-type zinc finger containing 1 [ Mus musculus (house mouse) ]

    Gene ID: 24105, updated on 21-Oct-2018

    Summary

    Official Symbol
    Rbck1provided by MGI
    Official Full Name
    RanBP-type and C3HC4-type zinc finger containing 1provided by MGI
    Primary source
    MGI:MGI:1344372
    See related
    Ensembl:ENSMUSG00000027466 Vega:OTTMUSG00000015834
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    UIP28; HOIL-1; HOIL-1L; AL033326; Ubce7ip3
    Expression
    Ubiquitous expression in adrenal adult (RPKM 103.1), thymus adult (RPKM 93.1) and 28 other tissues See more
    Orthologs

    Genomic context

    See Rbck1 in Genome Data Viewer
    Location:
    2; 2 G3
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 2 NC_000068.7 (152316334..152332643, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 2 NC_000068.6 (152142070..152158375, complement)

    Chromosome 2 - NC_000068.7Genomic Context describing neighboring genes Neighboring gene casein kinase 2, alpha 1 polypeptide Neighboring gene TBC1 domain family, member 20 Neighboring gene tribbles pseudokinase 3 Neighboring gene predicted gene 14164 Neighboring gene ribosomal protein, large, P0 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    double-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein kinase C binding ISO
    Inferred from Sequence Orthology
    more info
     
    transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    ubiquitin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    ubiquitin binding ISO
    Inferred from Sequence Orthology
    more info
     
    ubiquitin-protein transferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    ubiquitin-protein transferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    T cell receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of NF-kappaB transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of necroptotic process IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of I-kappaB kinase/NF-kappaB signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    positive regulation of I-kappaB kinase/NF-kappaB signaling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of I-kappaB kinase/NF-kappaB signaling ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of NF-kappaB transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of NIK/NF-kappaB signaling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of extrinsic apoptotic signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    proteasome-mediated ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    proteasome-mediated ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    protein linear polyubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein linear polyubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    protein polyubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    LUBAC complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    LUBAC complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    ranBP-type and C3HC4-type zinc finger-containing protein 1
    Names
    RING-type E3 ubiquitin transferase HOIL-1
    heme-oxidized IRP2 ubiquitin ligase 1 homolog
    novel zinc finger, C3HC4 type (RING finger) protein
    ubcM4-interacting protein 28
    ubiquitin-conjugating enzyme 7-interacting protein 3
    NP_001077390.1
    NP_062679.2
    XP_006499508.1
    XP_006499509.1
    XP_006499510.1
    XP_017173514.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001083921.1NP_001077390.1  ranBP-type and C3HC4-type zinc finger-containing protein 1 isoform a

      See identical proteins and their annotated locations for NP_001077390.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (a). Variants 1 and 2 both encode the same isoform (a).
      Source sequence(s)
      AI853834, AK085559, AK166075, CX238505
      Consensus CDS
      CCDS38273.1
      UniProtKB/Swiss-Prot
      Q9WUB0
      Related
      ENSMUSP00000105473.2, OTTMUSP00000016877, ENSMUST00000109847.8, OTTMUST00000037643
      Conserved Domains (4) summary
      cd01799
      Location:57131
      Hoil1_N; Ubiquitin-like domain of HOIL1
      smart00547
      Location:195215
      ZnF_RBZ; Zinc finger domain
      sd00029
      Location:195214
      zf-RanBP2; RanBP2-type Zn finger [structural motif]
      pfam13445
      Location:280322
      zf-RING_UBOX; RING-type zinc-finger
    2. NM_001355282.1NP_001342211.1  ranBP-type and C3HC4-type zinc finger-containing protein 1 isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) contains an alternate internal exon compared to variant 1. The resulting isoform (b) is shorter at the N-terminus compared to isoform a.
      Source sequence(s)
      AL831735, AL928568
      Conserved Domains (3) summary
      smart00547
      Location:4565
      ZnF_RBZ; Zinc finger domain
      sd00029
      Location:4564
      zf-RanBP2; RanBP2-type Zn finger [structural motif]
      cd16633
      Location:126180
      mRING-HC-C3HC3D_RBR_HOIL1; Modified RING finger, HC subclass (C3HC3D-type), found in heme-oxidized IRP2 ubiquitin ligase 1 (HOIL-1) and similar proteins
    3. NM_019705.3NP_062679.2  ranBP-type and C3HC4-type zinc finger-containing protein 1 isoform a

      See identical proteins and their annotated locations for NP_062679.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same isoform (a).
      Source sequence(s)
      AI853834, AK085559, AK166075, BY084037, BY267597
      Consensus CDS
      CCDS38273.1
      UniProtKB/Swiss-Prot
      Q9WUB0
      Related
      ENSMUSP00000028964.7, OTTMUSP00000016878, ENSMUST00000028964.13, OTTMUST00000037644
      Conserved Domains (4) summary
      cd01799
      Location:57131
      Hoil1_N; Ubiquitin-like domain of HOIL1
      smart00547
      Location:195215
      ZnF_RBZ; Zinc finger domain
      sd00029
      Location:195214
      zf-RanBP2; RanBP2-type Zn finger [structural motif]
      pfam13445
      Location:280322
      zf-RING_UBOX; RING-type zinc-finger

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000068.7 Reference GRCm38.p4 C57BL/6J

      Range
      152316334..152332643 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006499446.1XP_006499509.1  ranBP-type and C3HC4-type zinc finger-containing protein 1 isoform X1

      See identical proteins and their annotated locations for XP_006499509.1

      Conserved Domains (4) summary
      cd01799
      Location:56130
      Hoil1_N; Ubiquitin-like domain of HOIL1
      smart00547
      Location:194214
      ZnF_RBZ; Zinc finger domain
      sd00029
      Location:194213
      zf-RanBP2; RanBP2-type Zn finger [structural motif]
      pfam13445
      Location:279321
      zf-RING_UBOX; RING-type zinc-finger
    2. XM_006499447.3XP_006499510.1  ranBP-type and C3HC4-type zinc finger-containing protein 1 isoform X2

      Conserved Domains (3) summary
      cd01799
      Location:57131
      Hoil1_N; Ubiquitin-like domain of HOIL1
      smart00547
      Location:195215
      ZnF_RBZ; Zinc finger domain
      sd00029
      Location:195214
      zf-RanBP2; RanBP2-type Zn finger [structural motif]
    3. XM_006499445.3XP_006499508.1  ranBP-type and C3HC4-type zinc finger-containing protein 1 isoform X1

      See identical proteins and their annotated locations for XP_006499508.1

      Conserved Domains (4) summary
      cd01799
      Location:56130
      Hoil1_N; Ubiquitin-like domain of HOIL1
      smart00547
      Location:194214
      ZnF_RBZ; Zinc finger domain
      sd00029
      Location:194213
      zf-RanBP2; RanBP2-type Zn finger [structural motif]
      pfam13445
      Location:279321
      zf-RING_UBOX; RING-type zinc-finger
    4. XM_017318025.1XP_017173514.1  ranBP-type and C3HC4-type zinc finger-containing protein 1 isoform X3

      Conserved Domains (1) summary
      cl17238
      Location:159185
      RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

    RNA

    1. XR_866272.2 RNA Sequence

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