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    Klhl12 kelch-like 12 [ Mus musculus (house mouse) ]

    Gene ID: 240756, updated on 29-May-2018

    Summary

    Official Symbol
    Klhl12provided by MGI
    Official Full Name
    kelch-like 12provided by MGI
    Primary source
    MGI:MGI:2385619
    See related
    Ensembl:ENSMUSG00000026455 Vega:OTTMUSG00000021463
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    C3ip1
    Expression
    Ubiquitous expression in testis adult (RPKM 12.6), liver E14 (RPKM 11.8) and 28 other tissues See more
    Orthologs

    Genomic context

    See Klhl12 in Genome Data Viewer
    Location:
    1; 1 E4
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 1 NC_000067.6 (134455496..134490880)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 1 NC_000067.5 (136352132..136387450)

    Chromosome 1 - NC_000067.6Genomic Context describing neighboring genes Neighboring gene cytochrome b5 reductase 1 Neighboring gene adiponectin receptor 1 Neighboring gene RAB interacting factor Neighboring gene predicted gene 29376

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Pathways from BioSystems

    General gene information

    Markers

    Homology

    Clone Names

    • MGC7076

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    COPII vesicle coating IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    COPII vesicle coating ISO
    Inferred from Sequence Orthology
    more info
     
    ER to Golgi vesicle-mediated transport ISO
    Inferred from Sequence Orthology
    more info
     
    Wnt signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    neural crest cell development ISO
    Inferred from Sequence Orthology
    more info
     
    neural crest formation ISO
    Inferred from Sequence Orthology
    more info
     
    protein monoubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein monoubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    vesicle-mediated transport IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    COPII vesicle coat ISO
    Inferred from Sequence Orthology
    more info
     
    COPII-coated ER to Golgi transport vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    COPII-coated ER to Golgi transport vesicle ISO
    Inferred from Sequence Orthology
    more info
     
    Cul3-RING ubiquitin ligase complex ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasmic vesicle IEA
    Inferred from Electronic Annotation
    more info
     
    intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
     
    microtubule organizing center ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    kelch-like protein 12
    Names
    CUL3-interacting protein 1
    kelch-like protein C3IP1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001311136.1NP_001298065.1  kelch-like protein 12 isoform 1

      See identical proteins and their annotated locations for NP_001298065.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AK034170, CD364043
      Consensus CDS
      CCDS78687.1
      UniProtKB/Swiss-Prot
      Q8BZM0
      Related
      ENSMUSP00000027725.4, OTTMUSP00000023861, ENSMUST00000027725.10, OTTMUST00000050880
      Conserved Domains (5) summary
      smart00612
      Location:474520
      Kelch; Kelch domain
      PHA03098
      Location:46550
      PHA03098; kelch-like protein; Provisional
      sd00038
      Location:416459
      Kelch; KELCH repeat [structural motif]
      pfam00651
      Location:23126
      BTB; BTB/POZ domain
      pfam07707
      Location:135236
      BACK; BTB And C-terminal Kelch
    2. NM_153128.3NP_694768.1  kelch-like protein 12 isoform 2

      See identical proteins and their annotated locations for NP_694768.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice junction in the 3' coding sequence compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      AK034170, CD364043
      Consensus CDS
      CCDS35715.1
      UniProtKB/Swiss-Prot
      Q8BZM0
      Related
      ENSMUSP00000107851.1, OTTMUSP00000023860, ENSMUST00000112232.7, OTTMUST00000050879
      Conserved Domains (5) summary
      smart00612
      Location:494538
      Kelch; Kelch domain
      PHA03098
      Location:46523
      PHA03098; kelch-like protein; Provisional
      sd00038
      Location:319365
      Kelch; KELCH repeat [structural motif]
      pfam00651
      Location:23126
      BTB; BTB/POZ domain
      pfam07707
      Location:135236
      BACK; BTB And C-terminal Kelch

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000067.6 Reference GRCm38.p4 C57BL/6J

      Range
      134455496..134490880
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006529561.2XP_006529624.1  kelch-like protein 12 isoform X1

      See identical proteins and their annotated locations for XP_006529624.1

      UniProtKB/Swiss-Prot
      Q8BZM0
      Related
      ENSMUSP00000112227.1, ENSMUST00000116528.1
      Conserved Domains (5) summary
      smart00612
      Location:474520
      Kelch; Kelch domain
      PHA03098
      Location:46550
      PHA03098; kelch-like protein; Provisional
      sd00038
      Location:416459
      Kelch; KELCH repeat [structural motif]
      pfam00651
      Location:23126
      BTB; BTB/POZ domain
      pfam07707
      Location:135236
      BACK; BTB And C-terminal Kelch
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