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    Pik3c2b phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 beta [ Mus musculus (house mouse) ]

    Gene ID: 240752, updated on 6-Sep-2021

    Summary

    Official Symbol
    Pik3c2bprovided by MGI
    Official Full Name
    phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 betaprovided by MGI
    Primary source
    MGI:MGI:2685045
    See related
    Ensembl:ENSMUSG00000026447
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gm199; PI3K-C2b; PI3KC2beta; PI3K-C2beta; C330011J12Rik
    Expression
    Ubiquitous expression in colon adult (RPKM 14.0), spleen adult (RPKM 10.9) and 24 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Pik3c2b in Genome Data Viewer
    Location:
    1; 1 E4
    Exon count:
    36
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (132973410..133036429)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (133045672..133108691)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 1 NC_000067.5 (134942589..135005265)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene nuclear encoded tRNA lysine 26 (anticodon TTT) Neighboring gene predicted gene, 41953 Neighboring gene nuclear encoded tRNA lysine 25 (anticodon TTT) Neighboring gene predicted gene 28609 Neighboring gene predicted gene, 51647 Neighboring gene protein phosphatase 1, regulatory subunit 15B Neighboring gene VISTA enhancer mm971 Neighboring gene pleckstrin homology domain containing, family A member 6

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 1-phosphatidylinositol-3-kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables 1-phosphatidylinositol-3-kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables 1-phosphatidylinositol-4-phosphate 3-kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables 1-phosphatidylinositol-4-phosphate 3-kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables lipid kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables phosphatidylinositol kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in endocytic vesicle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    part_of phosphatidylinositol 3-kinase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta
    Names
    phosphoinositide-3-kinase, class 2, beta polypeptide
    NP_001092746.2
    XP_006529594.1
    XP_006529595.1
    XP_006529596.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001099276.2NP_001092746.2  phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta

      See identical proteins and their annotated locations for NP_001092746.2

      Status: VALIDATED

      Source sequence(s)
      AC107842, AC137948
      Consensus CDS
      CCDS48360.1
      UniProtKB/TrEMBL
      E9QAN8
      Related
      ENSMUSP00000076911.6, ENSMUST00000077730.7
      Conserved Domains (6) summary
      cd00895
      Location:9861339
      PI3Kc_C2_beta; Catalytic domain of Class II Phosphoinositide 3-kinase beta
      cd07290
      Location:13681476
      PX_PI3K_C2_beta; The phosphoinositide binding Phox Homology Domain of the Beta Isoform of Class II Phosphoinositide 3-Kinases
      cd04012
      Location:621793
      C2A_PI3K_class_II; C2 domain first repeat present in class II phosphatidylinositol 3-kinases (PI3Ks)
      cd08381
      Location:15041626
      C2B_PI3K_class_II; C2 domain second repeat present in class II phosphatidylinositol 3-kinases (PI3Ks)
      cd00869
      Location:812980
      PI3Ka_II; Phosphoinositide 3-kinase (PI3K) class II, accessory domain (PIK domain); PIK domain is conserved in all PI3 and PI4-kinases. Its role is unclear but it has been suggested to be involved in substrate presentation. In general, class II PI3-kinases ...
      pfam00794
      Location:363465
      PI3K_rbd; PI3-kinase family, ras-binding domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      132973410..133036429
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006529532.2XP_006529595.1  phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta isoform X1

      See identical proteins and their annotated locations for XP_006529595.1

      UniProtKB/TrEMBL
      E9QAN8
      Conserved Domains (6) summary
      cd00895
      Location:9861339
      PI3Kc_C2_beta; Catalytic domain of Class II Phosphoinositide 3-kinase beta
      cd07290
      Location:13681476
      PX_PI3K_C2_beta; The phosphoinositide binding Phox Homology Domain of the Beta Isoform of Class II Phosphoinositide 3-Kinases
      cd04012
      Location:621793
      C2A_PI3K_class_II; C2 domain first repeat present in class II phosphatidylinositol 3-kinases (PI3Ks)
      cd08381
      Location:15041626
      C2B_PI3K_class_II; C2 domain second repeat present in class II phosphatidylinositol 3-kinases (PI3Ks)
      cd00869
      Location:812980
      PI3Ka_II; Phosphoinositide 3-kinase (PI3K) class II, accessory domain (PIK domain); PIK domain is conserved in all PI3 and PI4-kinases. Its role is unclear but it has been suggested to be involved in substrate presentation. In general, class II PI3-kinases ...
      pfam00794
      Location:363465
      PI3K_rbd; PI3-kinase family, ras-binding domain
    2. XM_006529531.5XP_006529594.1  phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta isoform X1

      See identical proteins and their annotated locations for XP_006529594.1

      UniProtKB/TrEMBL
      E9QAN8
      Conserved Domains (6) summary
      cd00895
      Location:9861339
      PI3Kc_C2_beta; Catalytic domain of Class II Phosphoinositide 3-kinase beta
      cd07290
      Location:13681476
      PX_PI3K_C2_beta; The phosphoinositide binding Phox Homology Domain of the Beta Isoform of Class II Phosphoinositide 3-Kinases
      cd04012
      Location:621793
      C2A_PI3K_class_II; C2 domain first repeat present in class II phosphatidylinositol 3-kinases (PI3Ks)
      cd08381
      Location:15041626
      C2B_PI3K_class_II; C2 domain second repeat present in class II phosphatidylinositol 3-kinases (PI3Ks)
      cd00869
      Location:812980
      PI3Ka_II; Phosphoinositide 3-kinase (PI3K) class II, accessory domain (PIK domain); PIK domain is conserved in all PI3 and PI4-kinases. Its role is unclear but it has been suggested to be involved in substrate presentation. In general, class II PI3-kinases ...
      pfam00794
      Location:363465
      PI3K_rbd; PI3-kinase family, ras-binding domain
    3. XM_006529533.5XP_006529596.1  phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta isoform X2

      Conserved Domains (6) summary
      cd00895
      Location:7651118
      PI3Kc_C2_beta; Catalytic domain of Class II Phosphoinositide 3-kinase beta
      cd07290
      Location:11471255
      PX_PI3K_C2_beta; The phosphoinositide binding Phox Homology Domain of the Beta Isoform of Class II Phosphoinositide 3-Kinases
      cd04012
      Location:400572
      C2A_PI3K_class_II; C2 domain first repeat present in class II phosphatidylinositol 3-kinases (PI3Ks)
      cd08381
      Location:12831405
      C2B_PI3K_class_II; C2 domain second repeat present in class II phosphatidylinositol 3-kinases (PI3Ks)
      cd00869
      Location:591759
      PI3Ka_II; Phosphoinositide 3-kinase (PI3K) class II, accessory domain (PIK domain); PIK domain is conserved in all PI3 and PI4-kinases. Its role is unclear but it has been suggested to be involved in substrate presentation. In general, class II PI3-kinases ...
      pfam00794
      Location:142244
      PI3K_rbd; PI3-kinase family, ras-binding domain
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