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    Taf10 TATA-box binding protein associated factor 10 [ Mus musculus (house mouse) ]

    Gene ID: 24075, updated on 26-Sep-2022

    Summary

    Official Symbol
    Taf10provided by MGI
    Official Full Name
    TATA-box binding protein associated factor 10provided by MGI
    Primary source
    MGI:MGI:1346320
    See related
    Ensembl:ENSMUSG00000043866 AllianceGenome:MGI:1346320
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    30kDa; Taf2h; TAFII30
    Summary
    Enables DNA binding activity and promoter-specific chromatin binding activity. Acts upstream of or within several processes, including G1/S transition of mitotic cell cycle; hepatocyte differentiation; and regulation of DNA binding activity. Located in nucleus. Is expressed in several structures, including blastocyst; embryo mesenchyme; gut; nervous system; and sensory organ epithelium. Orthologous to human TAF10 (TATA-box binding protein associated factor 10). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in adrenal adult (RPKM 258.4), duodenum adult (RPKM 245.3) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Taf10 in Genome Data Viewer
    Location:
    7; 7 E3
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (105392101..105393586, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (105742894..105744375, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene dynein heavy chain domain 1 Neighboring gene mitochondrial ribosomal protein S36, pseudogene 2 Neighboring gene ribosomal RNA processing 8 Neighboring gene integrin linked kinase Neighboring gene tripeptidyl peptidase I Neighboring gene uncharacterized LOC118567524 Neighboring gene dachsous cadherin related 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    contributes_to RNA polymerase II general transcription initiation factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    contributes_to RNA polymerase II general transcription initiation factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables RNA polymerase II general transcription initiation factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables RNA polymerase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables enzyme binding ISO
    Inferred from Sequence Orthology
    more info
     
    contributes_to histone acetyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables nuclear estrogen receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables promoter-specific chromatin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables promoter-specific chromatin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in DNA-templated transcription initiation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within G1/S transition of mitotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in RNA polymerase II preinitiation complex assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in RNA polymerase II preinitiation complex assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in SAGA complex assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in allantois development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within embryo development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in embryonic placenta development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in gene expression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within hepatocyte differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in histone H3 acetylation IC
    Inferred by Curator
    more info
    PubMed 
    involved_in histone H3 acetylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in histone acetylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in histone acetylation IC
    Inferred by Curator
    more info
    PubMed 
    involved_in histone deubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in in utero embryonic development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in lateral mesodermal cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in limb development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within liver development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in mRNA transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in monoubiquitinated histone H2A deubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in monoubiquitinated histone deubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within multicellular organism growth IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in multicellular organism growth IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of DNA-templated transcription IC
    Inferred by Curator
    more info
    PubMed 
    involved_in positive regulation of transcription initiation by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within protein-containing complex assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within regulation of DNA binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of DNA repair IC
    Inferred by Curator
    more info
    PubMed 
    involved_in regulation of DNA-templated transcription IC
    Inferred by Curator
    more info
    PubMed 
    acts_upstream_of_or_within regulation of DNA-templated transcription TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in regulation of RNA splicing IC
    Inferred by Curator
    more info
    PubMed 
    acts_upstream_of_or_within regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in somitogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in transcription initiation at RNA polymerase II promoter IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in transcription initiation at RNA polymerase II promoter ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    part_of SAGA complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of SAGA complex IC
    Inferred by Curator
    more info
    PubMed 
    part_of SAGA complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in male germ cell nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in nucleus IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    part_of transcription factor TFIID complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of transcription factor TFIID complex ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    part_of transcription factor TFIID complex TAS
    Traceable Author Statement
    more info
    PubMed 
    part_of transcription factor TFTC complex IC
    Inferred by Curator
    more info
    PubMed 
    part_of transcription factor TFTC complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of transcription preinitiation complex IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    transcription initiation factor TFIID subunit 10
    Names
    TAF(II)30
    TAF10 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 30 kDa
    TAFII-30
    TATA box binding protein (TBP)-associated factor, RNA polymerase II, H, 30 kDa
    mTAFII30
    transcription initiation factor TFIID 30 kDa subunit

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_020024.3NP_064408.2  transcription initiation factor TFIID subunit 10

      See identical proteins and their annotated locations for NP_064408.2

      Status: PROVISIONAL

      Source sequence(s)
      BC031418
      Consensus CDS
      CCDS21660.1
      UniProtKB/Swiss-Prot
      Q8K0H5, Q9QYY5
      Related
      ENSMUSP00000118105.2, ENSMUST00000141116.2
      Conserved Domains (1) summary
      cd07982
      Location:115217
      TAF10; The TATA Binding Protein (TBP) Associated Factor 10

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      105392101..105393586 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006507814.5XP_006507877.1  transcription initiation factor TFIID subunit 10 isoform X1

      Conserved Domains (2) summary
      PRK12323
      Location:4115
      PRK12323; DNA polymerase III subunit gamma/tau
      cl02150
      Location:115152
      TAF10; The TATA Binding Protein (TBP) Associated Factor 10