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    Rngtt RNA guanylyltransferase and 5'-phosphatase [ Mus musculus (house mouse) ]

    Gene ID: 24018, updated on 5-Aug-2018

    Summary

    Official Symbol
    Rngttprovided by MGI
    Official Full Name
    RNA guanylyltransferase and 5'-phosphataseprovided by MGI
    Primary source
    MGI:MGI:1329041
    See related
    Ensembl:ENSMUSG00000028274 Vega:OTTMUSG00000004938
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    HCE; MCE1; AU020997
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 2.4), CNS E14 (RPKM 2.1) and 28 other tissues See more
    Orthologs

    Genomic context

    See Rngtt in Genome Data Viewer
    Location:
    4; 4 A5
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 4 NC_000070.6 (33310299..33502614)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 4 NC_000070.5 (33397286..33589585)

    Chromosome 4 - NC_000070.6Genomic Context describing neighboring genes Neighboring gene serine/arginine-rich splicing factor 12 Neighboring gene proline-rich nuclear receptor coactivator 1 Neighboring gene microRNA 8118 Neighboring gene predicted gene, 32893 Neighboring gene predicted gene, 32955

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    GTP binding IEA
    Inferred from Electronic Annotation
    more info
     
    RNA guanylyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    catalytic activity IEA
    Inferred from Electronic Annotation
    more info
     
    hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    mRNA guanylyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    mRNA guanylyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    nucleotidyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    polynucleotide 5'-phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein tyrosine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    protein tyrosine/serine/threonine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    triphosphatase activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    7-methylguanosine mRNA capping IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    7-methylguanosine mRNA capping ISO
    Inferred from Sequence Orthology
    more info
     
    RNA processing ISO
    Inferred from Sequence Orthology
    more info
     
    dephosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    mRNA processing IEA
    Inferred from Electronic Annotation
    more info
     
    metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    nucleus IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    mRNA-capping enzyme
    NP_001292202.1
    NP_036014.1
    XP_006537952.1
    XP_006537953.1
    XP_011248317.1
    XP_017175678.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001305273.1NP_001292202.1  mRNA-capping enzyme isoform 2

      See identical proteins and their annotated locations for NP_001292202.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate splice site in the 3' coding region, which causes a frame-shift compared to variant 1. The encoded isoform (2) has a shorter and distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AC093925, AK002922, AK142016, AK151463, BU756706, CO042079
      Consensus CDS
      CCDS84712.1
      UniProtKB/TrEMBL
      Q3UA94, Q9DCC1
      Related
      ENSMUSP00000029942.7, OTTMUSP00000005130, ENSMUST00000029942.7, OTTMUST00000010986
      Conserved Domains (3) summary
      cd07895
      Location:248461
      Adenylation_mRNA_capping; Adenylation domain of GTP-dependent mRNA capping enzymes
      pfam03919
      Location:465545
      mRNA_cap_C; mRNA capping enzyme, C-terminal domain
      cl21483
      Location:47143
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    2. NM_011884.3NP_036014.1  mRNA-capping enzyme isoform 1

      See identical proteins and their annotated locations for NP_036014.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoforom (1).
      Source sequence(s)
      AC093925, AK002922, AK142016, AK151463, BU756706, CO042079
      Consensus CDS
      CCDS38705.1
      UniProtKB/Swiss-Prot
      O55236
      UniProtKB/TrEMBL
      Q3UA94, Q9DCC1
      Related
      ENSMUSP00000103788.2, OTTMUSP00000005131, ENSMUST00000108153.8, OTTMUST00000010987
      Conserved Domains (3) summary
      cd07895
      Location:248461
      Adenylation_mRNA_capping; Adenylation domain of GTP-dependent mRNA capping enzymes
      pfam03919
      Location:465558
      mRNA_cap_C; mRNA capping enzyme, C-terminal domain
      cl21483
      Location:47143
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000070.6 Reference GRCm38.p4 C57BL/6J

      Range
      33310299..33502614
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017320189.1XP_017175678.1  mRNA-capping enzyme isoform X1

    2. XM_006537889.3XP_006537952.1  mRNA-capping enzyme isoform X2

      Conserved Domains (2) summary
      cd07895
      Location:248447
      Adenylation_mRNA_capping; Adenylation domain of GTP-dependent mRNA capping enzymes
      cl21483
      Location:47143
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    3. XM_006537890.3XP_006537953.1  mRNA-capping enzyme isoform X3

      Conserved Domains (2) summary
      cd07895
      Location:248456
      Adenylation_mRNA_capping; Adenylation domain of GTP-dependent mRNA capping enzymes
      cl21483
      Location:47143
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    4. XM_011250015.2XP_011248317.1  mRNA-capping enzyme isoform X4

      Conserved Domains (2) summary
      cd07895
      Location:248424
      Adenylation_mRNA_capping; Adenylation domain of GTP-dependent mRNA capping enzymes
      cl21483
      Location:47143
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
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