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    Rngtt RNA guanylyltransferase and 5'-phosphatase [ Mus musculus (house mouse) ]

    Gene ID: 24018, updated on 23-Jun-2021

    Summary

    Official Symbol
    Rngttprovided by MGI
    Official Full Name
    RNA guanylyltransferase and 5'-phosphataseprovided by MGI
    Primary source
    MGI:MGI:1329041
    See related
    Ensembl:ENSMUSG00000028274
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    HCE; MCE1; AU020997
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 2.4), CNS E14 (RPKM 2.1) and 28 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Rngtt in Genome Data Viewer
    Location:
    4; 4 A5
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (33310300..33502614)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (33310300..33502614)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 4 NC_000070.5 (33397286..33589585)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene serine and arginine-rich splicing factor 12 Neighboring gene proline-rich nuclear receptor coactivator 1 Neighboring gene microRNA 8118 Neighboring gene predicted gene, 52726 Neighboring gene predicted gene, 32893

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables RNA guanylyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables catalytic activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables mRNA guanylyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables mRNA guanylyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables nucleotidyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables phosphoprotein phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables polynucleotide 5'-phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein tyrosine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables triphosphatase activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in 7-methylguanosine mRNA capping IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in 7-methylguanosine mRNA capping ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in RNA processing ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in dephosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within mRNA processing IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    mRNA-capping enzyme
    NP_001292202.1
    NP_036014.1
    XP_006537952.1
    XP_006537953.1
    XP_011248317.1
    XP_017175678.2
    XP_030109377.1
    XP_036019988.1
    XP_036019989.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001305273.1NP_001292202.1  mRNA-capping enzyme isoform 2

      See identical proteins and their annotated locations for NP_001292202.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate splice site in the 3' coding region, which causes a frame-shift compared to variant 1. The encoded isoform (2) has a shorter and distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AC093925, AK002922, AK142016, AK151463, BU756706, CO042079
      Consensus CDS
      CCDS84712.1
      UniProtKB/TrEMBL
      Q3UA94, Q9DCC1
      Related
      ENSMUSP00000029942.8, ENSMUST00000029942.8
      Conserved Domains (3) summary
      cd07895
      Location:248461
      Adenylation_mRNA_capping; Adenylation domain of GTP-dependent mRNA capping enzymes
      pfam03919
      Location:465545
      mRNA_cap_C; mRNA capping enzyme, C-terminal domain
      cl21483
      Location:47143
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    2. NM_011884.3NP_036014.1  mRNA-capping enzyme isoform 1

      See identical proteins and their annotated locations for NP_036014.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoforom (1).
      Source sequence(s)
      AC093925, AK002922, AK142016, AK151463, BU756706, CO042079
      Consensus CDS
      CCDS38705.1
      UniProtKB/Swiss-Prot
      O55236
      UniProtKB/TrEMBL
      Q3UA94, Q9DCC1
      Related
      ENSMUSP00000103788.3, ENSMUST00000108153.9
      Conserved Domains (3) summary
      cd07895
      Location:248461
      Adenylation_mRNA_capping; Adenylation domain of GTP-dependent mRNA capping enzymes
      pfam03919
      Location:465558
      mRNA_cap_C; mRNA capping enzyme, C-terminal domain
      cl21483
      Location:47143
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      33310300..33502614
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017320189.3XP_017175678.2  mRNA-capping enzyme isoform X3

      Conserved Domains (2) summary
      cd07895
      Location:238451
      Adenylation_mRNA_capping; Adenylation domain of GTP-dependent mRNA capping enzymes
      cl28904
      Location:45165
      PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily
    2. XM_030253517.1XP_030109377.1  mRNA-capping enzyme isoform X7

      Conserved Domains (2) summary
      cd07895
      Location:238414
      Adenylation_mRNA_capping; Adenylation domain of GTP-dependent mRNA capping enzymes
      cl28904
      Location:45165
      PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily
    3. XM_036164096.1XP_036019989.1  mRNA-capping enzyme isoform X2

      Conserved Domains (2) summary
      cd07895
      Location:248461
      Adenylation_mRNA_capping; Adenylation domain of GTP-dependent mRNA capping enzymes
      cd17664
      Location:9175
      Mce1_N; N-terminal triphosphatase domain of mRNA capping enzyme
    4. XM_036164095.1XP_036019988.1  mRNA-capping enzyme isoform X1

      Conserved Domains (2) summary
      cd07895
      Location:248461
      Adenylation_mRNA_capping; Adenylation domain of GTP-dependent mRNA capping enzymes
      cd17664
      Location:9175
      Mce1_N; N-terminal triphosphatase domain of mRNA capping enzyme
    5. XM_006537889.5XP_006537952.1  mRNA-capping enzyme isoform X4

      Conserved Domains (2) summary
      cd07895
      Location:248447
      Adenylation_mRNA_capping; Adenylation domain of GTP-dependent mRNA capping enzymes
      cd17664
      Location:9175
      Mce1_N; N-terminal triphosphatase domain of mRNA capping enzyme
    6. XM_006537890.4XP_006537953.1  mRNA-capping enzyme isoform X5

      Conserved Domains (2) summary
      cd07895
      Location:248456
      Adenylation_mRNA_capping; Adenylation domain of GTP-dependent mRNA capping enzymes
      cd17664
      Location:9175
      Mce1_N; N-terminal triphosphatase domain of mRNA capping enzyme
    7. XM_011250015.3XP_011248317.1  mRNA-capping enzyme isoform X6

      Conserved Domains (2) summary
      cd07895
      Location:248424
      Adenylation_mRNA_capping; Adenylation domain of GTP-dependent mRNA capping enzymes
      cd17664
      Location:9175
      Mce1_N; N-terminal triphosphatase domain of mRNA capping enzyme
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