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    Ik IK cytokine [ Mus musculus (house mouse) ]

    Gene ID: 24010, updated on 24-Apr-2022

    Summary

    Official Symbol
    Ikprovided by MGI
    Official Full Name
    IK cytokineprovided by MGI
    Primary source
    MGI:MGI:1345142
    See related
    Ensembl:ENSMUSG00000024474 AllianceGenome:MGI:1345142
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    MuRED
    Summary
    Predicted to enable identical protein binding activity. Predicted to be involved in mRNA splicing, via spliceosome; mitotic spindle assembly checkpoint signaling; and protein localization to kinetochore. Predicted to act upstream of or within RNA splicing and mRNA processing. Predicted to be located in nuclear speck. Predicted to be part of U2-type precatalytic spliceosome. Predicted to be active in nucleus. Predicted to colocalize with mitotic spindle pole and nuclear chromosome. Is expressed in testis. Orthologous to human IK (IK cytokine). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in CNS E11.5 (RPKM 65.1), CNS E14 (RPKM 39.9) and 24 other tissues See more
    Orthologs
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    Genomic context

    Location:
    18; 18 B2
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (36877709..36890692)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (36744656..36757639)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 18 NC_000084.5 (36904310..36917293)

    Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene CD14 antigen Neighboring gene transmembrane and coiled-coil domains 6 Neighboring gene NADH:ubiquinone oxidoreductase subunit A2 Neighboring gene WD repeat domain 55 Neighboring gene DND microRNA-mediated repression inhibitor 1 Neighboring gene histidyl-tRNA synthetase Neighboring gene histidyl-tRNA synthetase 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within RNA splicing IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within mRNA processing IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in mRNA splicing, via spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in mRNA splicing, via spliceosome ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in mitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in mitotic spindle assembly checkpoint signaling ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein localization to kinetochore ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    part_of U2-type precatalytic spliceosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    colocalizes_with mitotic spindle pole ISO
    Inferred from Sequence Orthology
    more info
     
    colocalizes_with nuclear chromosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nuclear speck ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    part_of spliceosomal complex IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    protein Red
    Names
    IK factor
    arginine/glutamic acid/aspartic acid repeat containing protein
    cytokine IK

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_011879.2NP_036009.1  protein Red

      See identical proteins and their annotated locations for NP_036009.1

      Status: VALIDATED

      Source sequence(s)
      BC029694, BG084120, BM211698
      Consensus CDS
      CCDS57119.1
      UniProtKB/Swiss-Prot
      Q9Z1M8
      Related
      ENSMUSP00000007042.6, ENSMUST00000007042.6
      Conserved Domains (2) summary
      pfam07807
      Location:445554
      RED_C; RED-like protein C-terminal region
      pfam07808
      Location:83295
      RED_N; RED-like protein N-terminal region

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000084.7 Reference GRCm39 C57BL/6J

      Range
      36877709..36890692
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)