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    Lnpep leucyl/cystinyl aminopeptidase [ Mus musculus (house mouse) ]

    Gene ID: 240028, updated on 11-Sep-2021

    Summary

    Official Symbol
    Lnpepprovided by MGI
    Official Full Name
    leucyl/cystinyl aminopeptidaseprovided by MGI
    Primary source
    MGI:MGI:2387123
    See related
    Ensembl:ENSMUSG00000023845
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    CAP; vp1; IRAP; PLAP; gp16; gp160; vp165; 2010309L07Rik; 4732490P18Rik
    Expression
    Ubiquitous expression in heart adult (RPKM 7.9), thymus adult (RPKM 6.0) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Lnpep in Genome Data Viewer
    Location:
    17; 17 A3.2
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (17747985..17846303, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (17527723..17624489, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 17 NC_000083.5 (17664687..17761453, complement)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 26873 Neighboring gene limb and CNS expressed 1 Neighboring gene predicted gene, 41537 Neighboring gene proteasome (prosome, macropain) subunit, beta type 3 pseudogene Neighboring gene farnesyl diphosphate synthetase pseudogene Neighboring gene vomeronasal 2, receptor 90

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables aminopeptidase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables aminopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables metalloaminopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables metallopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables peptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables peptide binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables zinc ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within SMAD protein signal transduction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of cold-induced thermogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in peptide catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within protein catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in proteolysis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in regulation of blood pressure IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cytoplasmic vesicle membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasmic vesicle membrane TAS
    Traceable Author Statement
    more info
     
    located_in integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in integral component of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    located_in perinuclear region of cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    leucyl-cystinyl aminopeptidase
    Names
    OTase
    cystinyl aminopeptidase
    oxytocinase
    NP_766415.1
    XP_036016480.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_172827.3NP_766415.1  leucyl-cystinyl aminopeptidase

      See identical proteins and their annotated locations for NP_766415.1

      Status: PROVISIONAL

      Source sequence(s)
      AC121795, AC147983
      Consensus CDS
      CCDS37457.1
      UniProtKB/Swiss-Prot
      Q8C129
      Related
      ENSMUSP00000036998.3, ENSMUST00000041047.4
      Conserved Domains (3) summary
      cd09601
      Location:177617
      M1_APN_2; Peptidase M1 Aminopeptidase N family incudes tricorn interacting factor F3, Endoplasmic reticulum aminopeptidase 1 (ERAP1), Aminopeptidase Q (APQ)
      pfam01433
      Location:167552
      Peptidase_M1; Peptidase family M1
      pfam11838
      Location:6901005
      ERAP1_C; ERAP1-like C-terminal domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      17747985..17846303 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036160587.1XP_036016480.1  leucyl-cystinyl aminopeptidase isoform X1

      Conserved Domains (1) summary
      cd09601
      Location:177595
      M1_APN-Q_like; Peptidase M1 aminopeptidase N catalytic domain family which includes aminopeptidase N (APN), aminopeptidase Q (APQ), tricorn interacting factor F3, and endoplasmic reticulum aminopeptidase 1 (ERAP1)
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