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    Ptpn21 protein tyrosine phosphatase, non-receptor type 21 [ Mus musculus (house mouse) ]

    Gene ID: 24000, updated on 23-Jun-2021

    Summary

    Official Symbol
    Ptpn21provided by MGI
    Official Full Name
    protein tyrosine phosphatase, non-receptor type 21provided by MGI
    Primary source
    MGI:MGI:1344406
    See related
    Ensembl:ENSMUSG00000021009
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    PTP; PTPD1; PTPRL10
    Expression
    Ubiquitous expression in lung adult (RPKM 9.4), ovary adult (RPKM 9.3) and 28 other tissues See more
    Orthologs
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    Try the new Transcript table

    Genomic context

    See Ptpn21 in Genome Data Viewer
    Location:
    12; 12 E
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (98643000..98703664, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (98676741..98737613, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 12 NC_000078.5 (99914951..99975615, complement)

    Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 25486 Neighboring gene spermatogenesis associated 7 Neighboring gene zinc finger CCCH type containing 14 Neighboring gene echinoderm microtubule associated protein like 5 Neighboring gene predicted gene, 35463

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 

    General gene information

    Homology

    Clone Names

    • MGC107492

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables phosphoprotein phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein tyrosine phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables protein tyrosine phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in dephosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein dephosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    tyrosine-protein phosphatase non-receptor type 21
    Names
    protein-tyrosine phosphatase PTP-RL10
    NP_001139671.1
    NP_036007.2
    XP_011242414.1
    XP_036013301.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001146199.1NP_001139671.1  tyrosine-protein phosphatase non-receptor type 21

      See identical proteins and their annotated locations for NP_001139671.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC124516, AC159193, BC098500
      Consensus CDS
      CCDS26098.1
      UniProtKB/TrEMBL
      G5E8J4, Q4KML9
      Related
      ENSMUSP00000126975.2, ENSMUST00000170188.8
      Conserved Domains (6) summary
      smart00194
      Location:8981168
      PTPc; Protein tyrosine phosphatase, catalytic domain
      smart00295
      Location:24222
      B41; Band 4.1 homologues
      cd00047
      Location:9251168
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
      cd13188
      Location:217307
      FERM_C_PTPN14_PTPN21; FERM domain C-lobe of Protein tyrosine phosphatase non-receptor proteins 14 and 21 (PTPN14 and 21)
      pfam00373
      Location:109220
      FERM_M; FERM central domain
      pfam09379
      Location:2790
      FERM_N; FERM N-terminal domain
    2. NM_011877.2NP_036007.2  tyrosine-protein phosphatase non-receptor type 21

      See identical proteins and their annotated locations for NP_036007.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC124516, AC159193, BC098500
      Consensus CDS
      CCDS26098.1
      UniProtKB/TrEMBL
      G5E8J4, Q4KML9
      Related
      ENSMUSP00000082197.3, ENSMUST00000085116.4
      Conserved Domains (6) summary
      smart00194
      Location:8981168
      PTPc; Protein tyrosine phosphatase, catalytic domain
      smart00295
      Location:24222
      B41; Band 4.1 homologues
      cd00047
      Location:9251168
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
      cd13188
      Location:217307
      FERM_C_PTPN14_PTPN21; FERM domain C-lobe of Protein tyrosine phosphatase non-receptor proteins 14 and 21 (PTPN14 and 21)
      pfam00373
      Location:109220
      FERM_M; FERM central domain
      pfam09379
      Location:2790
      FERM_N; FERM N-terminal domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000078.7 Reference GRCm39 C57BL/6J

      Range
      98643000..98703664 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011244112.4XP_011242414.1  tyrosine-protein phosphatase non-receptor type 21 isoform X1

      Conserved Domains (1) summary
      cl28904
      Location:471757
      PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily
    2. XM_036157408.1XP_036013301.1  tyrosine-protein phosphatase non-receptor type 21 isoform X1

      Conserved Domains (1) summary
      cl28904
      Location:471757
      PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily
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